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Binuclear Non-Coupled Copper Enzymes in Neurobiology: An Integrated Computational/Spectroscopic Investigation

Objectif

"Every third protein contains metal as cofactor. Cu-enzymes plays crucial rules in key processes in bioenergetics, mitochondrial respiration, neurotransmitter biosynthesis, antioxidation and pigmentation Therefore they are intensive targets for discovering new drugs and the understanding of their structure-functions relationships will provide new insight in translational and biomedical research.
In this Marie Curie International Outgoing Fellowship I will investigate the mechanism of important two bi nuclear cupper enzyme – Peptidylglycine α-Amidating Monooxygenase (PAM) and Dopamine β-Monooxygense (DBM) which catalyze hydroxylation of substrates in crucial importance for neurobiology . The miss functionalities of these enzymes are related with nervous system disorders therefore revealing it mechanism will provide advanced opportunities for design of new drugs. In order to achieve this knowledge we will apply integrated combination of the most advanced spectroscopic techniques and state of the art computational methods."

Appel à propositions

FP7-PEOPLE-2010-IOF
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Coordinateur

UNIVERSITY OF NORTHUMBRIA AT NEWCASTLE
Contribution de l’UE
€ 258 386,80
Adresse
SUTHERLAND BUILDING COLLEGE STREET
NE1 8ST Newcastle Upon Tyne
Royaume-Uni

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Région
North East (England) Northumberland and Tyne and Wear Tyneside
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Gary Black (Prof.)
Liens
Coût total
Aucune donnée