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Content archived on 2024-06-18

European ResearcH on DevElopmentAL, BirtH and Genetic Determinants of Ageing

Objective

Developmental plasticity modulated by epigenetic processes such as methylation and post-translational modifications is influenced by early life events and determines risk of age related diseases later in life
We propose a multi-disciplinary approach incorporating biochemistry, genetics, epidemiology, epigenetics and bioinformatics to discover novel biomarkers of ageing and interventional pathways to reverse changes at an early stage. A consortium of 8 members including three SMEs leaders in genetics epigenetics, post-translational modifications and metabolomics will investigate plasticity in developmental changes at pre-natal, peri-natal and early life stages on ageing in three European cohorts with rich early life data and age-related health outcomes. The identical twin data which has extensive epigenetic, genetic and metabolomic data will be utilised as a “discovery” set and the other cohorts will be used for confirmation. This multi-disciplinary project will improve our understanding of the links between fetal or perinatal events and ageing process and by combining the latest technologies in genetics, epigenetics, metabolomics and post-translational modification technologies. It will allow to develop biomarkers of ageing that reflect the role of early development on ageing. Using the collective skills and experience of eight groups at the cutting edge of European genetic and ageing research this project will identify molecular biomarkers detectable in early life that can predict age-related health (or disease) outcomes and identify pathways for intervention that can be modified while changes are still reversible.

Fields of science (EuroSciVoc)

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Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-HEALTH-2011-two-stage
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

CP-FP - Small or medium-scale focused research project

Coordinator

KING'S COLLEGE LONDON
EU contribution
€ 997 627,50
Address
STRAND
WC2R 2LS London
United Kingdom

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Participants (8)

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