Objective
Activation of H2 is typically a domain of transition metal catalysis -even nature uses metal-centred reactions for this process. However, very recently Stephan and Erker have described metal free systems able to activate dihydrogen by the use of Frustrated Lewis Pairs (FLP), a combination of sterically hindered Lewis acids and Lewis bases that for this geometric reason are not able to quench each other. Moreover they were able to apply these systems for the reduction of some imines using H2 directly instead of any organic surrogate.
Although this process is quite interesting, its applicability is nevertheless quite limited. Only silylenol ethers and very bulky imines can be satisfactorily reduced, non-encumbered ones simply react directly with B(C6F5)3, the ubiquitous Lewis acid used to form FLPs. To circumvent this obvious drawback I propose a new approach consisting in the use of completely organic molecules such as electron-poor allenes, alkenes, iminium salts and ketones as attractive alternatives to B(C6F5)3. The development of a totally organic FLP able to activate H2 reversibly goes far beyond the state-of-the-art as it is expected to allow the reduction of carbon-carbon and carbon-heteroatom double bonds without the use of any metal and employing directly H2. This wide-ranging extension of the FLP reactivity will clearly surpass classical metal catalysis in environmental issues as no noble metal will be necessary. Also, organocatalytic reductions will be outstripped in atom economy criteria as H2 and no heavier surrogate will be used as reducing agent.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry ketones
- natural sciences chemical sciences catalysis
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2011-StG_20101014
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
37073 Gottingen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.