CORDIS
EU research results

CORDIS

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European Multicentre Tics in Children Studies

Project information

Grant agreement ID: 278367

Status

Closed project

  • Start date

    1 December 2011

  • End date

    31 May 2017

Funded under:

FP7-HEALTH

  • Overall budget:

    € 8 068 217,71

  • EU contribution

    € 6 000 000

Coordinated by:

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

Objective

This project will undertake pre-clinical and cohort studies that address susceptibility factors for paediatric and adolescent tic disorders, with a particular focus on comorbid obsessive-compulsive symptomatology, from clinical, epidemiological, genetic, microbiological and immunological angles. EMTICS aims to elucidate the complex aetiology of the onset and clinical course of chronic tic disorders and associated obsessive-compulsive symptoms, through disentangling the interplay between environmental factors and genetic background; translate research findings into clinical applications by developing disease prediction models and investigation of a treatment strategy; and will establish a Pan-European infrastructure for the study of tic disorders. We hypothesise that the onset and/or exacerbation of tic and comorbid obsessive-compulsive disorders is associated with increased preceding occurrence of Group A beta-haemolytic Streptococcus (GAS) infections of specific molecular subtypes, and that this association is based on genetic susceptibility factors and mediated through immunological mechanisms related to psychosocial stress and immunological factors in host and GAS strains. Large-scale cohort studies will involve affected patients and at-risk first-degree relatives within an integrated, multidisciplinary research strategy. Treatment effects of active surveillance and standardized antibiotic treatment of GAS colonisation, thus addressing one of the main environmental factors involved (GAS infections) will be evaluated. Our approach will result in the identification of genetic and environmental susceptibility factors and will greatly contribute to a better understanding of the underlying mechanisms of tic disorders, with a focus on elucidating the role of autoimmunity. Our consortium brings together the highest expertise in the field of tic disorders across Europe in academia and industry, including a number of SMEs and a professional management company.

Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN

Address

Hanzeplein 1
9713 Gz Groningen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 776 397

Administrative Contact

Pieter J. Hoekstra (Dr.)

Participants (29)

UNIVERSITA DEGLI STUDI DI BARI ALDO MORO

Italy

EU Contribution

€ 241 915

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 144 442

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 475 965

URWYLER ADRIAN - CYTOLAB

Switzerland

EU Contribution

€ 72 000

ISTITUTO SUPERIORE DI SANITA

Italy

EU Contribution

€ 713 967

Public Health England an Executive Agency of the Dept of Health

United Kingdom

TECHNISCHE UNIVERSITAET DRESDEN

Germany

EU Contribution

€ 289 762

DIMOKRITIO PANEPISTIMIO THRAKIS

Greece

EU Contribution

€ 240 541

PROIMMUNE LTD

United Kingdom

EU Contribution

€ 194 760

GLAXOSMITHKLINE VACCINES SRL

Italy

EU Contribution

€ 209 200

CLALIT HEALTH SERVICES

Israel

EU Contribution

€ 225 443

THE UNIVERSITY OF BIRMINGHAM

United Kingdom

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Italy

EU Contribution

€ 330 861

ADVANCED PRACTICAL DIAGNOSTICS

Belgium

EU Contribution

€ 144 360

QUEEN MARY UNIVERSITY OF LONDON

United Kingdom

EU Contribution

€ 264 928

UNIVERSITA DEGLI STUDI DI CATANIA

Italy

EU Contribution

€ 145 646

Concentris Research Management GmbH

Germany

EU Contribution

€ 360 000

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

Germany

VADASKERT ALAPITVANY A GYERMEKEK LELKI EGESZSEGEERT

Hungary

EU Contribution

€ 149 605

SERVICIO ANDALUZ DE SALUD

Spain

EU Contribution

€ 63 470

UNIVERSITAT ZURICH

Switzerland

EU Contribution

€ 135 023

FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA

Spain

EU Contribution

€ 106 846

REGION HOVEDSTADEN

Denmark

EU Contribution

€ 135 016

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

EU Contribution

€ 113 883

GUYS AND ST THOMAS' NHS FOUNDATIONTRUST

United Kingdom

EU Contribution

€ 179 443

AZIENDA SANITARIA LOCALE BARI

Italy

EU Contribution

€ 84 776

UNIVERSITAET zu LUEBECK

Germany

EU Contribution

€ 13 187

Department of Health

United Kingdom

EU Contribution

€ 148 603

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

EU Contribution

€ 39 961

Project information

Grant agreement ID: 278367

Status

Closed project

  • Start date

    1 December 2011

  • End date

    31 May 2017

Funded under:

FP7-HEALTH

  • Overall budget:

    € 8 068 217,71

  • EU contribution

    € 6 000 000

Coordinated by:

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands