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European Multicentre Tics in Children Studies

Ziel

This project will undertake pre-clinical and cohort studies that address susceptibility factors for paediatric and adolescent tic disorders, with a particular focus on comorbid obsessive-compulsive symptomatology, from clinical, epidemiological, genetic, microbiological and immunological angles. EMTICS aims to elucidate the complex aetiology of the onset and clinical course of chronic tic disorders and associated obsessive-compulsive symptoms, through disentangling the interplay between environmental factors and genetic background; translate research findings into clinical applications by developing disease prediction models and investigation of a treatment strategy; and will establish a Pan-European infrastructure for the study of tic disorders. We hypothesise that the onset and/or exacerbation of tic and comorbid obsessive-compulsive disorders is associated with increased preceding occurrence of Group A beta-haemolytic Streptococcus (GAS) infections of specific molecular subtypes, and that this association is based on genetic susceptibility factors and mediated through immunological mechanisms related to psychosocial stress and immunological factors in host and GAS strains. Large-scale cohort studies will involve affected patients and at-risk first-degree relatives within an integrated, multidisciplinary research strategy. Treatment effects of active surveillance and standardized antibiotic treatment of GAS colonisation, thus addressing one of the main environmental factors involved (GAS infections) will be evaluated. Our approach will result in the identification of genetic and environmental susceptibility factors and will greatly contribute to a better understanding of the underlying mechanisms of tic disorders, with a focus on elucidating the role of autoimmunity. Our consortium brings together the highest expertise in the field of tic disorders across Europe in academia and industry, including a number of SMEs and a professional management company.

Aufforderung zur Vorschlagseinreichung

FP7-HEALTH-2011-two-stage
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

CP-FP - Small or medium-scale focused research project

Koordinator

ACADEMISCH ZIEKENHUIS GRONINGEN
Adresse
Hanzeplein 1
9713 GZ Groningen
Niederlande
Aktivitätstyp
Higher or Secondary Education Establishments
EU-Beitrag
€ 776 397
Kontakt Verwaltung
Pieter J. Hoekstra (Dr.)

Beteiligte (29)

UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italien
EU-Beitrag
€ 241 915
Adresse
Piazza Umberto I 1
70121 Bari
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Maura Buttiglione (Dr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU-Beitrag
€ 144 442
Adresse
Gower Street
WC1E 6BT London
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Greta Borg-Carbott (Ms.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Deutschland
EU-Beitrag
€ 475 965
Adresse
Geschwister Scholl Platz 1
80539 Muenchen
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Norbert Mueller (Prof.)
URWYLER ADRIAN - CYTOLAB
Schweiz
EU-Beitrag
€ 72 000
Adresse
Rairing 66
8108 Dallikon
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Adrian Urwyler (Mr.)
ISTITUTO SUPERIORE DI SANITA
Italien
EU-Beitrag
€ 713 967
Adresse
Viale Regina Elena 299
00161 Roma
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Rosa Maria Martoccia (Dr.)
Public Health England an Executive Agency of the Dept of Health

Beteiligung beendet

United Kingdom
Adresse
Waterloo Road
SE1 8UG London
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Philip Luton (Dr.)
TECHNISCHE UNIVERSITAET DRESDEN
Deutschland
EU-Beitrag
€ 289 762
Adresse
Helmholtzstrasse 10
01069 Dresden
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Carsten Glück (Mr.)
DIMOKRITIO PANEPISTIMIO THRAKIS
Greece
EU-Beitrag
€ 240 541
Adresse
Panepistimioupoli Rectorate Building
69100 Komotini
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Peristera Paschou (Prof.)
PROIMMUNE LTD
United Kingdom
EU-Beitrag
€ 194 760
Adresse
Robert Robinson Avenue The Magdalen
OX4 4GA Oxford
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Nikolai Schwabe (Dr.)
GLAXOSMITHKLINE VACCINES SRL
Italien
EU-Beitrag
€ 209 200
Adresse
Via Fiorentina 1
53100 Siena
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Francesco Gulli (Dr.)
CLALIT HEALTH SERVICES
Israel
EU-Beitrag
€ 225 443
Adresse
Arlozorov Street 101
62098 Tel Aviv
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Keren Tochterman (Ms.)
THE UNIVERSITY OF BIRMINGHAM

Beteiligung beendet

United Kingdom
Adresse
Edgbaston
B15 2TT Birmingham
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
May Chung (Ms.)
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
Italien
EU-Beitrag
€ 330 861
Adresse
Piazzale Aldo Moro 5
00185 Roma
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Francesco Cardona (Dr.)
ADVANCED PRACTICAL DIAGNOSTICS
Belgien
EU-Beitrag
€ 144 360
Adresse
Raadsherenstraat 3
2300 Turnhout
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Aye Mu Myint (Dr.)
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
EU-Beitrag
€ 264 928
Adresse
327 Mile End Road
E1 4NS London
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Gavin Giovannoni (Prof.)
UNIVERSITA DEGLI STUDI DI CATANIA
Italien
EU-Beitrag
€ 145 646
Adresse
Piazza Universita 2
95131 Catania
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Francesco Murabito (Dr.)
Concentris Research Management GmbH
Deutschland
EU-Beitrag
€ 360 000
Adresse
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Ameli Schwalber (Ms.)
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

Beteiligung beendet

Deutschland
Adresse
Martinistrasse 52
20251 Hamburg
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Alexander Münchau (Prof.)
VADASKERT ALAPITVANY A GYERMEKEK LELKI EGESZSEGEERT
Ungarn
EU-Beitrag
€ 149 605
Adresse
Huvosvolgyi Ut 116
1021 Budapest
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Zsanett Tárnok (Dr.)
SERVICIO ANDALUZ DE SALUD
Spanien
EU-Beitrag
€ 63 470
Adresse
Avenida De La Constitucion 18
41071 Sevilla
Aktivitätstyp
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Kontakt Verwaltung
Sophie Monteau (Ms.)
University of Zurich
Schweiz
EU-Beitrag
€ 135 023
Adresse
Ramistrasse 71
8006 Zurich
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Susanne Walitza (Prof.)
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spanien
EU-Beitrag
€ 106 846
Adresse
Carrer Rossello 149
08036 Barcelona
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Pastora Martinez Samper (Ms.)
REGION HOVEDSTADEN
Dänemark
EU-Beitrag
€ 135 016
Adresse
Kongens Vaenge 2
3400 Hillerod
Aktivitätstyp
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Kontakt Verwaltung
Pernille Rosling (Ms.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Deutschland
EU-Beitrag
€ 113 883
Adresse
Carl-neuberg-strasse 1
30625 Hannover
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Frank Dittrich (Mr.)
GUYS AND ST THOMAS' NHS FOUNDATIONTRUST
United Kingdom
EU-Beitrag
€ 179 443
Adresse
Westminster Bridge Road
SE1 7EH London
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Peter Allanson (Mr.)
AZIENDA SANITARIA LOCALE BARI
Italien
EU-Beitrag
€ 84 776
Adresse
Lungomare Starita 6
70123 Bari
Aktivitätstyp
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Kontakt Verwaltung
Nicola Pansini (Dr.)
UNIVERSITAET zu LUEBECK
Deutschland
EU-Beitrag
€ 13 187
Adresse
Ratzeburger Allee 160
23562 Lubeck
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Gabriele Kipke (Mrs.)
Department of Health
United Kingdom
EU-Beitrag
€ 148 603
Adresse
Quarry House, Quarry Hill
LS2 7UE Leeds
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Phil Luton (Dr.)
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Niederlande
EU-Beitrag
€ 39 961
Adresse
Meibergdreef 15
1105AZ Amsterdam
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Eugenie Quartier (Mrs.)