Objective
Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life. Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity for newly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient delivery to the needs of the developing fetus. EpiHealth will focus on these early events in several relevant models(diabetes, obesity and assisted reproductive technologies (ART)),using human samples, stem cell lines, animal models and data mining/bioinformatics tools to decipher some of the most important pathways and to offer options for early intervention to avoid adverse health effects. Main goal of the project is to improve health of the human population by understanding the mechanisms and pathways in early development, with special emphasis on epigenetic changes and developmentally relevant metabolic signalling, which create biological variation and have a long term effect on the health of individuals across the lifespan. Specific goals include: i)Identification of the main genetic pathways affecting the health of the developing embryos in a diabetic or obese maternal environment; ii) Identification of the main genetic and metabolic pathways affected and epigenomic and imprinting perturbations from mouse and human ART resulting in altered health of the progeny; iii)Discovery of the key genes and pathways affecting epigenetic and imprinting sensitivity in early stages of development in order to create intervention tools against epigenetic mis-programming; iv)Linking for the first time by bioinformatics tools the longevity related pathways and those susceptible to early epigenetic perturbations in order to explain how early events influence the health and lifespan of individuals; v)Studying the possibilities of early intervention by controlling the maternal environment.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences data science data mining
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine embryology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-HEALTH-2011-two-stage
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2100 Goedoello
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.