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Linking perturbed maternal environment during periconceptional development, due to diabetes, obesity or assisted reproductive technologies, and altered health during ageing

Objective

Scientific evidence clearly indicates that ageing and health in adult life is programmed by genetic and epigenetic mechanisms early in life. Developmental plasticity in response to the environment, including nutrient availability, of mammalian embryos indicates the capacity for newly emerging embryonic and extraembryonic cell lineages to initiate compensatory responses which may attune nutrient delivery to the needs of the developing fetus. EpiHealth will focus on these early events in several relevant models(diabetes, obesity and assisted reproductive technologies (ART)),using human samples, stem cell lines, animal models and data mining/bioinformatics tools to decipher some of the most important pathways and to offer options for early intervention to avoid adverse health effects. Main goal of the project is to improve health of the human population by understanding the mechanisms and pathways in early development, with special emphasis on epigenetic changes and developmentally relevant metabolic signalling, which create biological variation and have a long term effect on the health of individuals across the lifespan. Specific goals include: i)Identification of the main genetic pathways affecting the health of the developing embryos in a diabetic or obese maternal environment; ii) Identification of the main genetic and metabolic pathways affected and epigenomic and imprinting perturbations from mouse and human ART resulting in altered health of the progeny; iii)Discovery of the key genes and pathways affecting epigenetic and imprinting sensitivity in early stages of development in order to create intervention tools against epigenetic mis-programming; iv)Linking for the first time by bioinformatics tools the longevity related pathways and those susceptible to early epigenetic perturbations in order to explain how early events influence the health and lifespan of individuals; v)Studying the possibilities of early intervention by controlling the maternal environment.

Call for proposal

FP7-HEALTH-2011-two-stage
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Coordinator

BIOTALENTUM TUDASFEJLESZTO KFT
Address
Aulich Lajos Utca 26
2100 Goedoello
Hungary
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 661 615,60
Administrative Contact
Andras Dinnyes (Prof.)

Participants (6)

UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 264 810,36
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yan Qiao (Ms.)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 516 006
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renata Schaeffer (Ms.)
MARTIN-LUTHER-UNIVERSITAT HALLE-WITTENBERG
Germany
EU contribution
€ 371 841,60
Address
Universitatsplatz 10
6108 Halle
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Peggy Patzner (Ms.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 417 305,64
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katherine Boylan (Dr.)
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
EU contribution
€ 346 136,80
Address
Olshausenstrasse 40
24118 Kiel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Susanne Neufeldt (Ms.)
AVANTEA srl
Italy
EU contribution
€ 364 640
Address
Via Cabrini 12
26100 Cremona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Cesare Galli (Prof.)