Objective NEURINOX aims at elucidating the role of NADPH oxidases (NOX) in neuroinflammation and its progression to neurodegenerative diseases (ND), as well as evaluating the potential of novel ND therapeutics approaches targeting NOX activity. NOX generate reactive oxygen species (ROS) and have emerged as regulators of neuroinflammation. Their role is complex: ROS generated by NOX lead to tissue damage in microglia-mediated neuroinflammation, as seen in amyotrophic lateral sclerosis (ALS), while absence of ROS generation enhances the severity of autoimmune-mediated neuroinflammation, as seen for e.g. in multiple sclerosis (MS).The objective of the 5 years NEURINOX project is to understand how NOX controls neuroinflammation, identify novel molecular pathways and oxidative biomarkers involved in NOX-dependent neuroinflammation, and develop specific therapies based on NOX modulation. The scientific approach will be to: (i) identify NOX-dependent molecular mechanisms using dedicated ND animal models (ii) develop therapeutic small molecules either inhibiting or activating NOX and test their effects in animal models (iii) test the validity of identified molecular pathways in clinical studies in ALS and MS patients.NEURINOX will contribute to better understand brain dysfunction, and more particularly the link between neuroinflammation and ND and to identify new therapeutic targets for ND. A successful demonstration of the benefits of NOX modulating drugs in ALS and MS animal models, and in ALS early clinical trials will validate a novel high potential therapeutics target for ALS and also many types of ND. NEURINOX has hence a strong potential for more efficient ND healthcare for patients and thus for reducing ND healthcare costs.This multi-disciplinary consortium includes leading scientists in NOX research, ROS biology, drug development SMEs, experts in the neuroinflammatory aspects of ND, genomics and proteomics, and clinicians able to translate the basic science to the patient. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesbasic medicineneurologymultiple sclerosisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymesmedical and health sciencesbasic medicineneurologyamyotrophic lateral sclerosis Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2011.2.2.1-2 - Understanding the role of neuroinflammation in neurodegenerative diseases Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator UNIVERSITE DE GENEVE EU contribution € 1 493 755,95 Address RUE DU GENERAL DUFOUR 24 1211 Geneve Switzerland See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Administrative Contact Karl-Heinz Krause (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (14) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITE JOSEPH FOURIER GRENOBLE 1 Participation ended France EU contribution No data Address Avenue Centrale, Domaine Universitaire 621 38041 GRENOBLE See on map Activity type Higher or Secondary Education Establishments Administrative Contact Sophie Beaubron (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data University of Zurich Switzerland EU contribution € 1 086 940,00 Address RAMISTRASSE 71 8006 ZURICH See on map Activity type Higher or Secondary Education Establishments Administrative Contact Adriano Aguzzi (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GENKYOTEX INNOVATION SAS France EU contribution € 1 129 402,00 Address DOMAINE DE CHOSAL 74160 ARCHAMPS See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rebecca Margarito (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data REDOXIS AB Sweden EU contribution € 770 800,00 Address MEDICON VILLAGE SCHEELEVAGEN 2 223 81 Lund See on map Region Södra Sverige Sydsverige Skåne län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Peter Olofsson (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ARTTIC France EU contribution € 560 341,00 Address 39 RUE DES MATHURINS 75008 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Eric Papon (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI TORINO Italy EU contribution € 866 670,00 Address VIA GIUSEPPE VERDI 8 10124 Torino See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Administrative Contact Donatella Amadori (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution € 1 983 090,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Jill Blomstrand (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UGA-Université Grenoble Alpes France EU contribution € 941 556,00 Address 621, AVENUE CENTRALE 38401 SAINT MARTIN D'HERES See on map Region RUP FR — Régions Ultrapériphériques Françaises Guadeloupe Guadeloupe Activity type Higher or Secondary Education Establishments Administrative Contact Sophie Beaubron (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SYNAPCELL France EU contribution € 683 000,00 Address ZONE D' ACTIVITE COMMERCIALE ISIPARC VILLAGE SCIEN 38330 SAINT ISMIER See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Isère Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Yann Roche (Dr.) Links Contact the organisation Opens in new window Total cost No data IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON Greece EU contribution € 1 158 090,05 Address SORANOU EFESIOU 4 115 27 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Administrative Contact Dimitris Raptis (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Greece EU contribution € 401 450,00 Address 6 CHRISTOU LADA STR 10561 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Higher or Secondary Education Establishments Administrative Contact Efstathia Kafentzi (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE UNIVERSITY OF SYDNEY Participation ended Australia EU contribution No data Address CAMPERDOWN CAMPUS ARUNDEL ST 71/79 2006 Sydney See on map Activity type Higher or Secondary Education Establishments Administrative Contact Kate Taylor (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NEURIX SA Switzerland EU contribution € 350 000,00 Address AVENUE DE LA ROSERAIE 64 1205 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Samuel Constant (Dr.) Links Contact the organisation Opens in new window Total cost No data VICTOR CHANG CARDIAC RESEARCH INSTITUTE LIMITED LBG Australia EU contribution No data Address LIVERPOOL STREET 405 2010 DARLINGHURST See on map Activity type Research Organisations Administrative Contact Kiran Narsey (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data