Objective Proteins are extremely malleable building blocks of life involved in all aspects of biology. Many diseases are caused by proteins aberrations, and proteins are frequent targets of intervention. Mapping all proteins and their functions are expected to yield pervasive medical and biotechnological benefits. However, even the most comprehensive and high-throughput proteins discovery technologies are seriously challenged by the extreme diversity and low abundance of many proteome components; a problem, compounded by the lack of affinity reagents and validated probes for sample preparation and identification. Our concept is that shorter protein fragments, or peptides, may offer solutions to many of these problems as peptides may represent or mimic proteins. Using in situ solid-phase peptide synthesis, computerized photolithography and novel photochemistry, we have recently generated peptide microarrays of up to 2 million addressable peptides. This unprecedented high-density and high-content peptide microarray technology could make inroads into the kind of high-throughput analysis needed to address the entire human proteome. Here, we aim to exploit this potential by using and improving three different, yet complementary, label-free detection technologies allowing sensitive, high-resolution determinations of the identity, quality and/or modification of individual members of a peptide microarray, and real-time monitoring of any interacting molecular receptor. We will also develop peptides as rapid, specific, and renewable affinity reagents for complex sample preparation, and develop peptides as probes and complex biosensors. Three SME’s constitute the backbone of this collaboration, receiving 50% of the budget, and enjoying significant opportunities from the booming protein/peptide microarray market. Furthermore, solutions to these unmet needs of proteomics are believed to have incalculable benefits for European health, innovativeness and competiveness. Fields of science engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsbiosensorsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural scienceschemical sciencesphysical chemistryphotochemistry Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.1.1-1 - SME-targeted research for developing tools and technologies for high-throughput research Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator KOBENHAVNS UNIVERSITET Address Norregade 10 1165 Kobenhavn Denmark See on map Region Danmark Hovedstaden Byen København Activity type Higher or Secondary Education Establishments Administrative Contact Ivan Kristoffersen (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all SCHAFER -N APS Denmark EU contribution € 1 061 166,80 Address Kystvej 6 3050 Humlebaek See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Claus Schafer Nielsen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ALIRI FRANCE SAS France EU contribution € 658 300,00 Address 152 rue du docteur yersin 59120 Loos See on map Region Hauts-de-France Nord-Pas de Calais Nord Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jonathan Stauber (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data PLASMORE SRL Italy EU contribution € 697 860,00 Address Viale vittorio emanuele ii 4 27100 Pavia See on map Region Nord-Ovest Lombardia Pavia Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Andrea Valsesia (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION Belgium EU contribution € 316 510,80 Address Rue de la loi 200 1049 Bruxelles / brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Research Organisations Administrative Contact Ian Formosa (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germany EU contribution € 147 831,00 Address Hansastrasse 27c 80686 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Walter Krause (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data BRUKER DALTONIK GMBH Germany EU contribution € 148 817,50 Address Fahrenheitstrasse 4 28359 Bremen See on map Region Bremen Bremen Bremen, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Tanja Lorek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE UNIVERSITY OF MANCHESTER United Kingdom EU contribution € 314 070,00 Address Oxford road M13 9PL Manchester See on map Region North West (England) Greater Manchester Manchester Activity type Higher or Secondary Education Establishments Administrative Contact Liz Fay (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY OF BATH United Kingdom EU contribution € 444 300,80 Address Claverton down BA2 7AY Bath See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bath and North East Somerset, North Somerset and South Gloucestershire Activity type Higher or Secondary Education Establishments Administrative Contact Hazel Wallis (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data DANMARKS TEKNISKE UNIVERSITET Denmark EU contribution € 316 547,25 Address Anker engelunds vej 101 2800 Kongens lyngby See on map Region Danmark Hovedstaden Københavns omegn Activity type Higher or Secondary Education Establishments Administrative Contact Jesper Thorsgaard (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
