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Imaging of Neuroinflammation in Neurodegenerative Diseases

Objective

The goal of this proposal (INMiND) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into the clinic. The general objectives of INMiND are:

(i) to identify novel mechanisms of regulation and function of microglia under various conditions (inflammatory stimuli; neurodegenerative and -regenerative model systems);
(ii) to identify and implement new targets for activated microglia, which may serve for diagnostic (imaging) and therapeutic purposes;
(iii) to design new molecular probes (tracers) for these novel targets and to implement and validate them in in vivo model systems and patients;
(iv) to image and quantify modulated microglia activity in patients undergoing immune therapy for cognitive impairment and relate findings to clinical outcome.

Within INMiND we bring together a group of excellent scientists with a proven background in efficiently accomplishing common scientific goals (FP6 project DiMI, www.dimi.eu) who belong to highly complementary fields of research (from genome-oriented to imaging scientists and clinicians), and who are dedicated to formulate novel image-guided therapeutic strategies for neuroinflammation related neurodegenerative diseases. The strength of this proposal is that, across Europe, it will coordinate research and training activities related to neuroinflammation, neurodegeneration/-regeneration and imaging with special emphasis on translating basic mechanisms into clinical applications that will provide health benefits for our aging population. With its intellectual excellence and its crucial mass the INMiND consortium will play a major role in the European Research Area and will gain European leadership in the creation of new image-guided therapy paradigms in patients with neurodegenerative diseases.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Coordinator

Westfälische Wilhelms-Universität Münster
Address
Schlossplatz 2
48149 Muenster
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 519 723,40
Administrative Contact
Sabine Stötzer (Dr.)

Participants (30)

UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 648 031,32
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Valentina Coppola (Dr.)
PARACELSUS MEDIZINISCHE PRIVATUNIVERSITAT SALZBURG - PRIVATSTIFTUNG
Austria
EU contribution
€ 449 687,76
Address
Strubergasse 21
5020 Salzburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ludwig Aigner (Prof.)
UNIVERSITE DE TOURS
France
EU contribution
€ 401 760
Address
Rue Du Plat D Etain 60
37020 Tours
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Aurélie Uchard (Ms.)
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 438 500
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alessandro De Filippo (Mr.)
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
Spain
EU contribution
€ 447 760
Address
Calle Rossello 149 Puerta Bjs
08036 Barcelona
Activity type
Other
Administrative Contact
Pastora Martinez (Dr.)
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 437 760
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Adams (Ms.)
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 437 760
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
Administrative Contact
Simone Mergui (Dr.)
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

Participation ended

Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Adriaan Lammertsma (Prof.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 1 154 297
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Claire Faichnie
UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy
EU contribution
€ 427 000
Address
Via Olgettina 58
20132 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Maria Rosa Pedrazzi (Dr.)
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 617 000
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christer Halldin (Prof.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 630 880
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sarah Malevé (Ms.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 427 000
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Gitte Moos Knudsen (Prof.)
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 277 333
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
Administrative Contact
Marcello Mancini (Dr.)
VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA
Finland
EU contribution
€ 393 360
Address
Kiinamyllynkatu 4-8
20520 Turku
Activity type
Research Organisations
Administrative Contact
Jari-Pekka Tuominen
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 437 000
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Emma Mills (Ms.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 399 588,84
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Scott Wheatley (Mr.)
THE UNIVERSITY OF SYDNEY
Australia
Address
Camperdown Campus Arundel St 71/79
2006 Sydney
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Kassiou (Prof.)
SEMMELWEIS EGYETEM
Hungary
EU contribution
€ 177 760
Address
Ulloi Utca 26
1085 Budapest
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Msz Kellermayer (Prof.)
UNIVERSITATSKLINIKUM BONN
Germany
EU contribution
€ 386 880
Address
Venusberg-campus 1
53127 Bonn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beate Becker
TOP (TRANSGENIC OPERATIVE PRODUCTS) S.R.L.

Participation ended

Italy
EU contribution
€ 144 968,68
Address
Via Einstein
26900 Lodi Lo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Paolo Ciana (Dr.)
CYCLOTRON VRIJE UNIVERSITEIT BV
Netherlands
EU contribution
€ 244 500
Address
De Boelelaan 1081
1081HV Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Johan Van Westendorp
CAGE CHEMICALS SRL
Italy
EU contribution
€ 194 000
Address
Via Bovio 6
28100 Novara
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Camilla Cavallotti (Dr.)
Pharmidex Pharmaceutical Services Limited
United Kingdom
EU contribution
€ 367 488
Address
Hanover Street 14 Floor 3
W1S 1RR London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mo Alavijeh (Mr.)
Mediso Orvosi Berendezes Fejleszto es Szerviz Kft.
Hungary
EU contribution
€ 253 440
Address
Alsotorokvesz 14
1022 Budapest
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Laszlo Kamocsai
NEUROSEARCH AS

Participation ended

Denmark
Address
Pederstrupvej 93
2750 Ballerup
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lars Christian B. Rønn (Dr.)
ANIONA APS
Denmark
EU contribution
€ 180 000
Address
Baltorpvej 154
2750 Ballerup
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thomas Feldthus (Mr.)
UNIVERSITE PARIS DESCARTES
France
EU contribution
€ 10 000
Address
Rue De L Ecole De Medecine 12
75270 Paris Cedex 06
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Valérie Hernu (Ms.)
STICHTING VU

Participation ended

Netherlands
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Adriaan Lammertsma (Prof.)
STICHTING VUMC
Netherlands
EU contribution
€ 495 000
Address
De Boelelaan 1117
1081 HV Amsterdam
Activity type
Research Organisations
Administrative Contact
Yvonne Koppelman (Dr.)