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The effect of intracoronary reinfusion of bone marrow-derived mononuclear cells (BM-MNC) on all-cause mortality in acute myocardial infarction

Objective

Although the long term prognosis of patients suffering acute myocardial infarction (AMI) has improved since the introduction of reperfusion therapies and primary angioplasty, the 1 year mortality of patients with AMI and resultant left ventricular systolic dysfunction (LVSD) is still as high as 13%. A major reason for the high morbidity and mortality is that the heart has an inadequate regenerative response to the myocardial necrosis sustained following AMI; cell death from the ischaemic damage can lead to progressive ventricular dilation and dysfunction through the processes of vascular remodelling. Despite the use of full conventional treatment, including ACE inhibitors, beta-blockers, aldosterone inhibitors and diuretics, yearly mortality rates of patients with post-infarction heart failure are still in the range of 13 % and rehospitalisation for worsening of heart failure occurs at a yearly rate of 6–8%.

Clinical data now exists supporting the concept that autologous bone marrow derived cells can restore cardiac function following AMI. We plan to advance this research in the BAMI project and will:
• Develop a standardised method of bone marrow cell collection
• Develop a standardised method of optimising reparative potential of bone marrow derived cells
• Standardise bone marrow preparation procedure so that it can be universally applied
• Standardise method of bone marrow cell delivery post AMI
• Conduct the first large scale all-cause mortality clinical trial to test if the product and delivery method mentioned above can lead to a 25% reduction in mortality end-point at 2 years

Our project will establish the therapeutic value of this approach to stem cell therapy. Success will demonstrate that transcoronary infusion of bone marrow-derived progenitor cells is safe and will reduce the mortality rate by 25% and reduce the rehospitalisation rate by 15%.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Coordinator

QUEEN MARY UNIVERSITY OF LONDON
Address
327 Mile End Road
E1 4NS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 979 853,55
Administrative Contact
Dylbere Koteci (Mrs.)

Participants (21)

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 19 842,43
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Christophe Misse (Mr.)
KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium
EU contribution
€ 476 995,20
Address
Oude Markt 13
3000 Leuven
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tine Heylen (Ms.)
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN

Participation ended

Germany
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mareike Schmitt (Ms.)
INSTITUT CATALA DE LA SALUT
Spain
EU contribution
€ 154 191,92
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Ramon Cosialls (Mr.)
EURAM LIMITED

Participation ended

United Kingdom
EU contribution
€ 258 936,87
Address
Lucy Tower Street Tower House
LN1 1XW Lincoln
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Andrew Banasik (Mr.)
UCL Elizabeth Garrett Anderson Institute for Women’s Health
United Kingdom
EU contribution
€ 21 384,89
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Greta Borg-Carbott (Ms.)
T2CURE GMBH
Germany
EU contribution
€ 163 955,23
Address
Kennedyallee 93
60596 Frankfurt Am Main
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Susanne Knigge (Ms.)
CARDIOVASCULAR RESEARCH CENTER AALST VZW
Belgium
EU contribution
€ 111 275
Address
Moorselbaan 164
9300 Aalst
Activity type
Research Organisations
Administrative Contact
Jozef Bartunek (Dr.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 22 464,12
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Dittrich (Mr.)
FAKULTNI NEMOCNICE BRNO
Czechia
EU contribution
€ 151 882,63
Address
Jihlavska 20
625 00 Brno
Activity type
Research Organisations
Administrative Contact
Iveta Mareschova (Ms.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 136 776,16
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Jens Kastrup (Prof.)
UNIVERSITA CATTOLICA DEL SACRO CUORE
Italy
EU contribution
€ 205 270,04
Address
Largo Gemelli 1
20123 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Filippo Leone (Mr.)
KING'S COLLEGE HOSPITAL NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 138 265,49
Address
Denmark Hill
SE5 9RS London
Activity type
Research Organisations
Administrative Contact
Kathryn Huggins (Ms.)
SLASKI UNIWERSYTET MEDYCZNY W KATOWICACH

Participation ended

Poland
EU contribution
€ 2 699,53
Address
Ul. Poniatowskiego 15
40 055 Katowice
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Barbara Jarzebska (Ms.)
UNIVERSITAET ROSTOCK

Participation ended

Germany
Address
Universitatsplatz 1
18055 Rostock
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gustav Steinhoff (Prof.)
CELYAD
Belgium
EU contribution
€ 185 836,88
Address
Rue Edouard Belin 12
1435 Mont Saint Guibert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Jeanmart (Mr.)
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 113 136,90
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Reinikainen (Ms.)
OSLO UNIVERSITETSSYKEHUS HF

Participation ended

Norway
Address
Kirkeveien 166 Tarnbygget
0450 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ketil Lunde (Prof.)
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 540 710,60
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Thierry Bardinet (Mr.)
THE UNIVERSITY OF EXETER
United Kingdom
EU contribution
€ 165 701,20
Address
The Queen's Drive Northcote House
EX4 4QJ Exeter
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gaynor Hughes (Ms.)
KLINIKUM DER JOHANN WOLFGANG VON GOETHE UNIVERSITAET
Germany
EU contribution
€ 1 143 904,36
Address
Theodor Stern Kai 7
60596 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kseniya Polozheyeva (Ms.)