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A stealth attack tool for preventing clinical drug resistance through a unique self-regenerating surface

Objective

Outbreaks of clinical infections affect many thousands of patients in Europe yearly. The present effective treatment for infections is large doses of systemically applied drugs. There is a high risk of recurring infections and biofilm formation for patients dependent on long term in-dwelling catheters and the extended dependency on antibiotics result in clinical drug resistance. We present a new tool for minimizing drug resistance by upgrading existing and future medical devices through a unique self-regenerating surface that prevents biofilm formation by a two-fold stealth attack mechanism. This will be achieved by an interpenetrating polymer network (IPN) that allows for long term release of a range of antimicrobial strategies, such as antimicrobial peptides (AMPs) . The IPNs contain hydrogels where the AMP is stored until the release starts at the insertion of the device with an expected long-term effect. The first line of defence will be a fixed galvanic noble metal alloy coating that will prevent bacteria from colonizing the surface. Local and site-specific treatment with long term effect instead of systemic treatment implies improved patient management and citizen well-fare.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance
  • /social sciences/sociology/governance/public services

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

TEKNOLOGISK INSTITUT
Address
Gregersensvej 1
2630 Taastrup
Denmark
Activity type
Research Organisations
EU contribution
€ 823 780
Administrative Contact
Anne-Lise Høg Lejre (Dr.)

Participants (6)

WEIZMANN INSTITUTE OF SCIENCE
Israel
EU contribution
€ 316 550
Address
Herzl Street 234
7610001 Rehovot
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Talia Tzahor (Ms.)
BIOMODICS APS
Denmark
EU contribution
€ 475 740
Address
Stengards Alle 31 A
2800 Kgs Lyngby
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Peter Thomsen (Dr.)
LABORATOIRE D'EVALUTION DES MATERIELS IMPLANTABLES SA
France
EU contribution
€ 367 564
Address
Technopole Bordeaux-montesquieu, Allée François Magendie 2
33650 Martillac
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Pierre Gonfrier (Mr.)
BACTIGUARD AB
Sweden
EU contribution
€ 539 200
Address
Biblioteksgatan 25
10242 Stockholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Mattias Ohrlander (Dr.)
NOVOZYMES A/S
Denmark
EU contribution
€ 128 983
Address
Krogshoejvej 36
2880 Bagsvaerd
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Nina Eckert Busgaard (Ms.)
ST GEORGE'S HOSPITAL MEDICAL SCHOOL
United Kingdom
EU contribution
€ 338 881
Address
Cranmer Terrace
SW17 0RE London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anthony Coates (Prof.)