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Genetic and environmental factors of insulin resistance syndrome and its long-term complications in immigrant Mediterranean populations

Objective

MEDIGENE project will study genetic and environmental (G x E) determinants of the metabolic syndrome (MetS) in recent immigrants in Europe by a novel approach integrating ancestry of Mediterranean populations in epidemiology, locus refining and Genome Wide Association Studies (GWAS). West Mediterranean shores are place of pre-historical termini of population expansion from Southern Europe and North Africa. Archaeogenetic studies in Europe indicated that Y chromosome and mitochondrial DNA patterns or Ancestry Informative Markers (AIMs) revealed a close relationship between genetic and geographic distances able to locate an individual DNA within few hundred kilometers. The project will use this information in mapping the genetic basis of insulin resistance, cardiovascular and metabolic complications in immigrants (Albanians, Romanians, Turkish, Tunisians, Algerians and Morocco) in host countries France, Spain, Italy and Greece. Ancestry markers and studies on ancient DNA from Roman historical migration in Catalonia will help to give a better picture of the genetic landscape of Europe and North Africa. Genes for MetS will be studied in existing samples from host and home countries by GWAS, locus refining by next-generation sequencing and haplotype mapping. Informative filtered SNPs will be then used in epidemiology and novel DNA samples to reveal G x E interactions and specificities of the pathogenesis of MetS. Genetic findings will be replicated in home countries (Anatolia and North Africa) in the goal to develop markers ethnic specific and significant at a clinical scale. Major impact is expected from dissemination of our findings to prevent the occurrence of MetS and obesity in children and adolescents or in descendants of modern immigration, understanding variability clinical manifestations of MetS in the context of malnutrition and from the novel approach of GWAS strategies by ameliorating the association signal and bursting R&D activities of SMEs.

Field of science

  • /medical and health sciences/health sciences/epidemiology
  • /natural sciences/biological sciences/genetics and heredity/dna
  • /social sciences/sociology/demography/human migration

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA)

Coordinator

UNIVERSITE DE MONTPELLIER
Address
163 Rue Auguste Broussonnet
34090 Montpellier
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 326 427
Administrative Contact
Christophe Normand (Mr.)

Participants (22)

CENTRO DE INVESTIGACION BIOMEDICA EN RED DE DIABETES Y ENFERMEDADES METABOLICAS

Participation ended

Spain
EU contribution
€ 260 301
Address
Mallorca 183
08036 Barcelona
Activity type
Research Organisations
Administrative Contact
Ana Bosch (Ms.)
UNIVERSITE MONTPELLIER I.

Participation ended

France
EU contribution
€ 681 736
Address
Bd Henri Iv,5
34060 Montpellier
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Christophe Normand (Mr.)
UNIVERSITE LYON 1 CLAUDE BERNARD
France
EU contribution
€ 84 000
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Javier Olaiz (Dr.)
CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P.
Spain
Address
Calle Monforte De Lemos 5
28029 Madrid
Activity type
Research Organisations
Administrative Contact
Ana Bosch (Ms.)
Institut Català d'Arqueologia Clàssica
Spain
EU contribution
€ 110 940
Address
Plaça Rovellat S/n
43003 Tarragona
Activity type
Research Organisations
Administrative Contact
Josep Maria Macias Sole (Dr.)
UNIVERSITATEA DE MEDICINA SI FARMACIE CAROL DAVILA DIN BUCURESTI
Romania
EU contribution
€ 132 614
Address
Dionisie Lupu 37
020021 Bucuresti
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mihail Coculescu (Prof.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 161 940
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renato Pasquali (Prof.)
UNIVERSITA DEGLI STUDI MAGNA GRAECIA DI CATANZARO
Italy
EU contribution
€ 96 912
Address
Viale Europa Localita Germaneto
88100 Catanzaro
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Giorgio Sesti (Prof.)
FONDAZIONE CASA SOLLIEVO DELLA SOFFERENZA
Italy
EU contribution
€ 114 000
Address
Viale Cappuccini Sc
71013 San Giovanni Rotondo Fg
Activity type
Research Organisations
Administrative Contact
Michele Giuliani (Dr.)
UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Italy
EU contribution
€ 150 000
Address
Via Cracovia 50
00133 Roma
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Davide Lauro (Prof.)
PANEPISTIMIO IOANNINON
Greece
EU contribution
€ 190 800
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Georgios Detsikas (Mr.)
INSTITUTE OF BIOCHEMISTRY AND GENETICS, UFA SCIENTIFIC CENTRE OF RAS
Russia
EU contribution
€ 87 705
Address
Prospekt Oktyabrya 71
450054 Ufa
Activity type
Research Organisations
Administrative Contact
Elza Khusnutdinova (Prof.)
INSTITUT PASTEUR DE TUNIS
Tunisia
EU contribution
€ 151 680
Address
Place Pasteur 13
1002 Tunis
Activity type
Research Organisations
Administrative Contact
Sonia Abdelhak (Prof.)
UNIVERSITE D'ALGER 1
Algeria
EU contribution
€ 67 448
Address
Rue Didouche Mourad 02
016000 Alger
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mahmoud Benali Abdallah (Prof.)
Institut Pasteur Du Maroc
Morocco
EU contribution
€ 63 195
Address
Place Louis Pasteur 1
20360 Casablanca
Activity type
Research Organisations
Administrative Contact
Abdelhamid Barakat (Dr.)
UNIVERSITETI I TIRANES

Participation ended

Albania
Address
Rr Desh E Kombit
1000 Tirana
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Agron Ylli (Prof.)
BIOCOMPUTING PLATFORMS LTD OY
Finland
EU contribution
€ 133 854
Address
Innopoli 3 Vaisalantie 6
02130 Espoo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Timo Kanninen (Mr.)
PERSONMED KFT

Participation ended

Hungary
Address
Mora Ferenc Utca 50 1 Em
7632 Pecs
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Robert Hermann (Dr.)
ISTANBUL UNIVERSITESI
Turkey
EU contribution
€ 71 635
Address
Istanbul Universitesi Center Campus Beyazit Eminonu
34452 Istanbul
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yildiz Tutuncu (Dr.)
Intactile SAS
France
EU contribution
€ 50 880
Address
20 Rue Du Carre Du Roi
34000 Montpellier
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Louis Ollagnon (Mr.)
INSTITUT ZA ANTROPOLOGIJU
Croatia
EU contribution
€ 14 940
Address
Ljudevita Gaja 32
10000 Zagreb
Activity type
Research Organisations
Administrative Contact
Morana Jarec (Mrs.)
UNIVERSITETI I MJEKESISE TIRANE
Albania
EU contribution
€ 45 900
Address
Rruga E Dibres 371
1005 Tirana
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Visar Sylaj (Dr.)