Objetivo
MEDIGENE project will study genetic and environmental (G x E) determinants of the metabolic syndrome (MetS) in recent immigrants in Europe by a novel approach integrating ancestry of Mediterranean populations in epidemiology, locus refining and Genome Wide Association Studies (GWAS). West Mediterranean shores are place of pre-historical termini of population expansion from Southern Europe and North Africa. Archaeogenetic studies in Europe indicated that Y chromosome and mitochondrial DNA patterns or Ancestry Informative Markers (AIMs) revealed a close relationship between genetic and geographic distances able to locate an individual DNA within few hundred kilometers. The project will use this information in mapping the genetic basis of insulin resistance, cardiovascular and metabolic complications in immigrants (Albanians, Romanians, Turkish, Tunisians, Algerians and Morocco) in host countries France, Spain, Italy and Greece. Ancestry markers and studies on ancient DNA from Roman historical migration in Catalonia will help to give a better picture of the genetic landscape of Europe and North Africa. Genes for MetS will be studied in existing samples from host and home countries by GWAS, locus refining by next-generation sequencing and haplotype mapping. Informative filtered SNPs will be then used in epidemiology and novel DNA samples to reveal G x E interactions and specificities of the pathogenesis of MetS. Genetic findings will be replicated in home countries (Anatolia and North Africa) in the goal to develop markers ethnic specific and significant at a clinical scale. Major impact is expected from dissemination of our findings to prevent the occurrence of MetS and obesity in children and adolescents or in descendants of modern immigration, understanding variability clinical manifestations of MetS in the context of malnutrition and from the novel approach of GWAS strategies by ameliorating the association signal and bursting R&D activities of SMEs.
Ámbito científico
Convocatoria de propuestas
FP7-HEALTH-2011-two-stage
Consulte otros proyectos de esta convocatoria
Régimen de financiación
CP-FP-SICA - Small/medium-scale focused research project for specific cooperation actions dedicated to international cooperation partner countries(SICA)Coordinador
34090 MONTPELLIER
Francia
Ver en el mapa
Participantes (22)
La participación finalizó
34967 MONTPELLIER
Ver en el mapa
69622 Villeurbanne Cedex
Ver en el mapa
28029 Madrid
Ver en el mapa
La participación finalizó
08017 Barcelona
Ver en el mapa
43003 Tarragona
Ver en el mapa
020021 Bucuresti
Ver en el mapa
40126 Bologna
Ver en el mapa
88100 Catanzaro
Ver en el mapa
71013 San Giovanni Rotondo Fg
Ver en el mapa
00133 Roma
Ver en el mapa
45110 Ioannina
Ver en el mapa
450054 UFA
Ver en el mapa
1002 Tunis
Ver en el mapa
016000 ALGER
Ver en el mapa
20360 Casablanca
Ver en el mapa
La participación finalizó
1000 Tirana
Ver en el mapa
02130 Espoo
Ver en el mapa
La participación finalizó
7632 PECS
Ver en el mapa
34452 Istanbul
Ver en el mapa
34000 MONTPELLIER
Ver en el mapa
10000 Zagreb
Ver en el mapa
1005 Tirana
Ver en el mapa