Objetivo The remarkable way that Nature prepares complex natural products has always been a source of inspiration to scientists, stimulating the development of new synthetic methods and strategies, as elegantly demonstrated by biomimetic approaches to total synthesis. Similarly, the performance and specificity of enzymes, perfected though evolution, offer ideals of selectivity and specificity that synthetic chemists aspire to. This proposal aims to develop an internationally leading research programme inspired by Nature’s ability to selectively generate diverse products from simple materials with exquisite levels of regio- and enantiocontrol. We aspire to synthetically emulate the elegant behaviour of Nature’s building blocks, such as co-enzyme A, in their ability to generate synthetic diversity (such as polyketides and alkaloids) from a simple and common starting material. Using this blueprint, we intend to selectively control the synthesis of a diverse range of bespoke stereodefined carbo- and heterocycles from readily available starting materials using simple man-made catalysts. We specifically aim to develop new strategies within the field of organic catalysis, focused upon the development of methods for the in situ catalytic generation of chiral ammonium enolates from carboxylic acids and their employment in catalysis. We also propose to develop a comprehensive mechanistic understanding of these processes. In preliminary work we have delineated a simple and efficient approach to this problem by employing chiral isothioureas as asymmetric catalysts, and we aim to build on the insight provided by these studies to develop this powerful concept into a generally applicable synthetic strategy. Ámbito científico natural scienceschemical sciencesorganic chemistryorganic acidsnatural scienceschemical sciencescatalysissocial scienceseconomics and businessbusiness and managementemploymentnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programa(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Tema(s) ERC-SG-PE5 - ERC Starting Grant - Materials and Synthesis Convocatoria de propuestas ERC-2011-StG_20101014 Consulte otros proyectos de esta convocatoria Régimen de financiación ERC-SG - ERC Starting Grant Institución de acogida THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS Aportación de la UE € 1 497 005,00 Dirección NORTH STREET 66 COLLEGE GATE KY16 9AJ St Andrews Reino Unido Ver en el mapa Región Scotland Eastern Scotland Clackmannanshire and Fife Tipo de actividad Higher or Secondary Education Establishments Investigador principal Andrew David Smith (Dr.) Contacto administrativo Trish Starrs (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Beneficiarios (1) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS Reino Unido Aportación de la UE € 1 497 005,00 Dirección NORTH STREET 66 COLLEGE GATE KY16 9AJ St Andrews Ver en el mapa Región Scotland Eastern Scotland Clackmannanshire and Fife Tipo de actividad Higher or Secondary Education Establishments Investigador principal Andrew David Smith (Dr.) Contacto administrativo Trish Starrs (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos