Objective
"We live in a ""24 hour"" culture, with transatlantic air travel and shift-work being part of normal life for many people. These types of desynchronisations (e.g. “jet-lag”) disrupt our daily physiology and are increasingly being linked to diseases such as diabetes, obesity and cancer. Daily rhythms are also impaired in the elderly, and in patients with common neurodegenerative conditions such as Alzheimer-type and fronto-temporal dementias, meaning that clock disruption is widespread in modern society. We know that every cell in the body has its own molecular clock, allowing it to coordinate its daily activities accurately, just as we would use a clock in our daily lives. Our work has uncovered novel mechanisms about how this works and how this fundamental timing system may have evolved in primitive single-celled organisms. By understanding these basic cellular mechanisms in greater detail, we anticipate that we will gain insights into how metabolic oscillations in each cell contribute to normal physiology and therefore disease."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences basic medicine neurology dementia
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine physiology
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2011-StG_20101109
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
CB2 1TN Cambridge
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.