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Metabolic oscillations and the 24 hour (circadian) clockwork

Objectif

"We live in a ""24 hour"" culture, with transatlantic air travel and shift-work being part of normal life for many people. These types of desynchronisations (e.g. “jet-lag”) disrupt our daily physiology and are increasingly being linked to diseases such as diabetes, obesity and cancer. Daily rhythms are also impaired in the elderly, and in patients with common neurodegenerative conditions such as Alzheimer-type and fronto-temporal dementias, meaning that clock disruption is widespread in modern society. We know that every cell in the body has its own molecular clock, allowing it to coordinate its daily activities accurately, just as we would use a clock in our daily lives. Our work has uncovered novel mechanisms about how this works and how this fundamental timing system may have evolved in primitive single-celled organisms. By understanding these basic cellular mechanisms in greater detail, we anticipate that we will gain insights into how metabolic oscillations in each cell contribute to normal physiology and therefore disease."

Appel à propositions

ERC-2011-StG_20101109
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Régime de financement

ERC-SG - ERC Starting Grant

Institution d’accueil

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Adresse
Trinity Lane The Old Schools
CB2 1TN Cambridge
United Kingdom

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Type d’activité
Higher or Secondary Education Establishments
Chercheur principal
Akhilesh Basi Reddy (Dr.)
Contact administratif
Renata Schaeffer (Ms.)
Contribution de l’UE
€ 1 998 056

Bénéficiaires (1)

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Contribution de l’UE
€ 1 998 056
Adresse
Trinity Lane The Old Schools
CB2 1TN Cambridge

Voir sur la carte

Type d’activité
Higher or Secondary Education Establishments
Chercheur principal
Akhilesh Basi Reddy (Dr.)
Contact administratif
Renata Schaeffer (Ms.)