Objective "I propose to develop a new generation of molecular photoacoustic imaging technologies and methods capable of detecting single deep tissue cells in preclinical studies of tissue regeneration. In order to achieve this goal, an interdisciplinary research programme involving physicists, engineers and life scientists is required to address the following objectives: 1) the development of novel photoacoustic imaging technology that provides high sensitivity and acquisition speed, 2) the development of the theoretical framework and experimental methods for quantitative imaging, 3) the development of novel genetically expressed reporters, and 4) the preclinical application in small animal models of tissue regeneration. This will result in a preclinical imaging modality has the potential to combine single cell sensitivity and microscale spatial resolution in deep (centimetre range) tissue regions with molecular, physiological, and anatomical imaging capabilities. The instrumentation and methodologies developed in this project will be applied to noninvasive, longitudinal, and quantitative studies of stem cell driven tissue regeneration, such as angiogenesis in bone fractures and muscle trauma. It will allow the detection and tracking of single stem cells and the probing of stem cell function. This will provide unprecedented opportunities for correlating cellular localization, migration, and function and with anatomical changes - knowledge that can be exploited to develop novel drugs and cell-based clinical therapies. Crucially, the technologies and methodologies developed in this project will be directly applicable to a wide range of other fields of the life sciences, such as cancer research and neurology." Fields of science medical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncologyengineering and technologymedical engineeringdiagnostic imagingmedical and health sciencesbasic medicineneurology Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-SG-LS7 - Applied life sciences, biotechnology and bioengineering: agricultural, animal, fishery, forestry/food sciences; biotechnology, chemical biology, genetic engineering, synthetic biology, industrial biosciences; environmental biotechnology. Call for proposal ERC-2011-StG_20101109 See other projects for this call Funding Scheme ERC-SG - ERC Starting Grant Coordinator TECHNISCHE UNIVERSITAT BERLIN Address Strasse des 17 juni 135 10623 Berlin Germany See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Principal investigator Gottfried Jan Laufer (Dr.) Administrative Contact Silke Hönert (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Beneficiaries (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all TECHNISCHE UNIVERSITAT BERLIN Germany EU contribution € 928 308,80 Address Strasse des 17 juni 135 10623 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Principal investigator Gottfried Jan Laufer (Dr.) Administrative Contact Silke Hönert (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany EU contribution € 694 427,20 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Martina Eickmann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
