Skip to main content

Resistance in Gram-Negative Organisms: Studying Intervention Strategies

Objective

Antibiotics are a mainstay of public health, but their use has increased exponentially leading to the emergence of antibiotic resistance. The R-GNOSIS (Resistance in Gram-Negative Organisms: Studying Intervention Strategies) project combines 5 international clinical studies, all supported by highly innovative microbiology, mathematical modelling and data-management, to determine - in the most relevant patient populations - the efficacy and effectiveness of cutting-edge interventions to reduce carriage, infection and spread of Multi-Drug Resistant Gram-negative Bacteria (MDR-GNB). All work-packages will progress science beyond the state-of-the-art in generating new and translational clinically relevant knowledge, through hypothesis-driven studies focussed on patient-centred outcomes.
The 5 clinical studies will investigate the following interventions:
•A Point-Of-Care-Testing guided management strategy to improve appropriate antibiotic prescription for uncomplicated UTI in primary care.
•Gut decolonization in outpatients with intestinal carriage of MDR-GNB.
•A “test and prescribe” strategy, based on rapid diagnostic testing of faeces for MDR-GNB to optimize antibiotic prophylaxis in colo-rectal surgery.
•Contact Isolation of patients with ESBL-producing Enterobacteriaceae in general hospital wards.
•Three Decolonization strategies in ICUs.
Seven laboratories across Europe will perform microbiological analyses, as well as unique quantitative experiments. All information will be integrated by 3 groups of mathematical modellers into highly innovative models to better understand and predict future trends and effects of interventions. The studies and analyses proposed in R-GNOSIS will generate a step-change in identifying evidence-based preventive measures and clinical guidance for primary care and hospital-based physicians and health-care authorities, to combat the spread and impact of infections caused by MDR-GNB in Europe.

Call for proposal

FP7-HEALTH-2011-single-stage
See other projects for this call

Coordinator

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Address
Heidelberglaan 100
3584 CX Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 4 164 036,18
Administrative Contact
E. Van Geenen (Dr.)

Participants (23)

UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 969 064,68
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephan Harbarth (Prof.)
UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 972 490
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Adams (Ms.)
THE FOUNDATION FOR MEDICAL RESEARCH INFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV
Israel
EU contribution
€ 1 276 652,84
Address
Weizmann Street 6
64239 Tel Aviv
Activity type
Research Organisations
Administrative Contact
Meital Kazma-Matalon (Ms.)
Public Health England an Executive Agency of the Dept of Health

Participation ended

United Kingdom
EU contribution
€ 631,68
Address
Waterloo Road
SE1 8UG London
Activity type
Research Organisations
Administrative Contact
Ann Grant (Ms.)
UNIVERSITE PARIS XII VAL DE MARNE
France
EU contribution
€ 162 110,99
Address
Avenue Du General De Gaulle 61
94010 Creteil
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Charlotte Laurent (Ms.)
UNIVERSITE PARIS-SUD

Participation ended

France
EU contribution
€ 84 942,55
Address
Rue Georges Clemenceau 15
91405 Orsay Cedex
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sandra Mereu (Ms.)
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 936 549
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eevi Laukkanen (Ms.)
UNIVERSITY OF SOUTHAMPTON
United Kingdom
EU contribution
€ 238 905
Address
Highfield
SO17 1BJ Southampton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Yan Qiao (Ms.)
SOCIEDAD ESPANOLA DE MEDICINA DE FAMILIA Y COMUNITARIA
Spain
EU contribution
€ 195 808
Address
C Portaferrissa 8
08002 Barcelona
Activity type
Other
Administrative Contact
Joan Saumell (Mr.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 756 573
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fraessdorf (Ms.)
UNIVERSITE PARIS DIDEROT - PARIS 7

Participation ended

France
Address
Rue Thomas Mann 5
75205 Paris
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Bonvalet (Ms.)
DA VOLTERRA SAS
France
EU contribution
€ 177 039,20
Address
Rue De Charonne 172 Le Dorian Batiment B
75011 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Florence Séjourné (Ms.)
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 385 922
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
José Ignacio Flores Nicolás (Mr.)
STATENS SERUM INSTITUT
Denmark
EU contribution
€ 77 268
Address
Artillerivej 5
2300 Kobenhavn S
Activity type
Research Organisations
Administrative Contact
Lars Villiam Pallesen (Dr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 392 153
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephen Conway (Dr.)
ARTTIC
France
EU contribution
€ 407 000
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Eric Papon (Dr.)
CHECK-POINTS HEALTH BV
Netherlands
EU contribution
€ 48 750
Address
Binnenhaven 5
6709 PD Wageningen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Niki Beelen (Ms.)
GENEWAVE SAS

Participation ended

France
EU contribution
€ 51 411,11
Address
Rue Pierre Fontaine 4
91000 Evry
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philippe Loiseau (Dr.)
APTATECK BIO LTD

Participation ended

Israel
Address
Golda Meir Boulevard 7
74036 Ness Ziona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ofer Nussbaum (Dr.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 242 510
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
Administrative Contact
Christophe Misse (Mr.)
HUMFRYX S.C
Spain
EU contribution
€ 40 482
Address
Roger De Flor 211 Planta 3-2A
08025 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Josep Maria Cots Yago (Dr.)
Department of Health
United Kingdom
EU contribution
€ 319 142,32
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
Administrative Contact
Ann Grant (Ms.)
UNIVERSITE DE FRIBOURG
Switzerland
EU contribution
€ 100 557,45
Address
Avenue De L Europe 20
1700 Fribourg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Monique Bersier (Ms.)