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Planetary Habitat Simulation

Objective

The aim is to investigate the combined effects of hypoxia and sustained recumbency (bedrest), on human physiological systems. The partial pressure of oxygen in the environmental gas inside future planetary habitats will be lower than in atmospheric air. Prolonged exposure to low gravity will result in deconditioning of vital physiological systems, and may consequently constitute a threat to the health of the astronauts. However, it is unknown how prolonged exposure to both reduced gravity and hypoxia will affect health. The new knowledge has also implications for society in general, since chronic hypoxia and bedrest constitutes a model of the basic conditions experienced by patients suffering from respiratory insufficiency restricting them to a physically inactive life style. The challenge of the project lies in the complexity of the experimental interventions where healthy humans are confined to a hypoxic environment during prolonged bedrest. A series of studies will be conducted at the Planica hypoxia facility capable of housing 20 subjects at any simulated altitude. Subjects will remain in horizontal position (bedrest) or be ambulatory, but confined to the facility (ambulation) for 21 days/trial. Each subject will participate in three trials: hypoxic bedrest (simulated altitude 4000m), normoxic bedrest, and hypoxic ambulation. The effects will be investigated in experiments concerning metabolic, cardiorespiratory, musculoskeletal, haematological, immunological and thermoregulatory functions. In addition to the specific objectives, the study will be explorative in the sense that it will collect a broad spectrum of basic data corresponding to that obtained when 21-day bedrest experiments are conducted by ESA/NASA (bedrest core data). Thus, data from the experiments can readily be compared with core data from previous bedrest studies, and hence the added effects of hypoxia should be evident.

Call for proposal

FP7-SPACE-2011-1
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Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

INSTITUT JOZEF STEFAN
Address
Jamova 39
1000 Ljubljana
Slovenia
Activity type
Research Organisations
EU contribution
€ 303 955
Administrative Contact
Igor Kovac (Dr.)

Participants (8)

KUNGLIGA TEKNISKA HOEGSKOLAN
Sweden
EU contribution
€ 284 895,74
Address
Brinellvagen 8
100 44 Stockholm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ola Eiken (Dr.)
DEUTSCHES ZENTRUM FUR LUFT - UND RAUMFAHRT EV
Germany
EU contribution
€ 164 539,50
Address
Linder Hohe
51147 Koln
Activity type
Research Organisations
Administrative Contact
Maximo Casas (Mr.)
UNIVERSITA DEGLI STUDI DI UDINE
Italy
EU contribution
€ 203 064,75
Address
Via Palladio 8
33100 Udine
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bruno Grassi (Prof.)
POLITECNICO DI MILANO
Italy
EU contribution
€ 202 566,95
Address
Piazza Leonardo Da Vinci 32
20133 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrea Aliverti (Prof.)
THE UNIVERSITY OF NOTTINGHAM
United Kingdom
EU contribution
€ 234 775,82
Address
University Park
NG7 2RD Nottingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Cartledge (Mr.)
UNIVERSITA DEGLI STUDI DI TRIESTE
Italy
EU contribution
€ 204 518,69
Address
Piazzale Europa 1
34127 Trieste
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gianni Biolo (Prof.)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 281 659,55
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alexander Choukèr (Dr.)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Participation ended

Germany
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Eveline Fräßdorf (Ms.)