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Marine nanobiotechnology: Manganese oxide-containing core-shell materials formed by proteins from marine organisms for biomedical and environmental applications

Objective

Core-shell materials are of enormous interest for many applications in nanotechnology and nanomedicine. Only recently, due to the achievements of the consortium, the generation of such nanoparticles by applying unique proteins from marine organisms has become possible. In this IAPP, based on a long-term and very successful cooperation between groups in Germany and Croatia, well known in the field of marine biotechnology of sponges and associated microorganisms, and now extended by an SME (NanotecMARIN GmbH) with a special focus on the exploitation of marine metal-oxide forming enzymes / proteins, a marine bacterial multicopper oxidase (MCO) and a sponge laccase, which are able to catalyze the oxidation of Mn(II) to Mn(IV), will be used to generate novel metal oxide nanocomposite materials. Enzymatically active MCO will be immobilized on magnetic iron oxide nanoparticles to enzymatically fabricate core-shell materials. In addition, MCO and laccase will be applied in combination with silica or other metal oxide-forming proteins (recombinant silicatein and silintaphin-1) to generate nanoparticles containing multiple shells of various materials, which can be doped with fluorescent dyes and proteins during their formation at mild conditions. These core-shell nanoparticles will be used in drug delivery, for removal of manganese or other heavy metals from contaminated aqueous solutions (remediation of contaminated environments), as well as for the development of antifouling strategies.

Call for proposal

FP7-PEOPLE-2011-IAPP
See other projects for this call

Coordinator

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Address
Langenbeckstrasse 1
55131 Mainz
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 148 222
Administrative Contact
Werner E.G. Müller (Prof.)

Participants (2)

RUDER BOSKOVIC INSTITUTE
Croatia
EU contribution
€ 297 296
Address
Bijenicka Cesta 54
10000 Zagreb
Activity type
Research Organisations
Administrative Contact
Renato Batel (Prof.)
NANOTECMARIN GMBH
Germany
EU contribution
€ 410 504
Address
Muhlstrasse 19
55218 Ingelheim Am Rhein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Heinz C. Schröder (Prof.)