Objective
With the BioEMERGENCES project, we aim at providing an experimental platform to observe in vivo emergent patterns at various scales and measure their variability between different individuals of the same species. This is a strategy towards the measurement of the individual susceptibility to genetic diseases or response to treatments. Emergent patterns arising at all levels of living organisms are influenced both by the external environment (top-down) and by the internal environment (bottom-up). As a consequence, two living beings are different even if they are two clones of the same species because the history of their coupling with their external environment is different. For these reasons, medicine evolves towards personalised protocols. To make them tangible, we have to be able to achieve the measurement at all organisation levels of the individual response to genetic defects or xenobiotics.
The impossible measurement of individual differences will be tackled in a live vertebrate organism -the zebrafish- that has been largely validated as a powerful model for investigations related to human. Selected emergent phenomena arising at various scales will be recorded and reconstructed to measure the qualitative and quantitative differences between two classes of individuals. Measuring the individual response to a new class of anti-cancer drugs -the DRIL molecules- and the individual susceptibility to holoprosencephaly in a genetically deficient fish population will serve as a testbed for our experimental platform.
The main result expected from BioEMERGENCES is the specification of a European platform to achieve high throughput measurement of individual differences and screening of drugs combinations such as bi or tri-therapies. Such a platform will allow responding t o both the unavoidable scientific question of the construction of a synthetic description of individuals and the future requirement for new drugs in the field of personalized nano-medicine.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- humanities history and archaeology history
- medical and health sciences medical biotechnology nanomedicine
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-NEST-PATH
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.