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Development of Cytochrome P450 Enzymes for the Chemical Manufacturing Industries

Objective

The objective of the P4FIFTY project is to deliver a trans-European network of industrially oriented white biotechnologists fully trained in the application of cytochrome P450 monooxygenases (P450s) for application in the chemical manufacturing and pharmaceutical industries. This will
involve academic groups investigating P450 diversity exploration from the wild type enzymes and their genes, genome mining for novel P450s, the expression of these in suitable hosts, the enzymology and molecular biological manipulation of these (including directed evolution and high
throughput screening [HTS] methods), the chemical application and finally the chemical and biochemical engineering aspects of application. These inputs are supported by two industrial partners one from the pharmaceutical industries (drug metabolism and synthesis) and one from the large scale chemical manufacturing industry.

Call for proposal

FP7-PEOPLE-2011-ITN
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Coordinator

UNIVERSITY OF YORK
Address
Heslington
YO10 5DD York North Yorkshire
United Kingdom

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
David Hudson (Mr.)
EU contribution
€ 865 000,89

Participants (9)

THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 528 394,06
Address
Oxford Road
M13 9PL Manchester

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Liz Fay (Ms.)
UNIVERSITY OF STUTTGART
Germany
EU contribution
€ 466 565,24
Address
Keplerstrasse 7
70174 Stuttgart

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bernhard Hauer (Prof.)
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 500 979,57
Address
Broerstraat 5
9712CP Groningen

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Poutsma (Mr.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 262 345,62
Address
Rue Michel Ange 3
75794 Paris

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Activity type
Research Organisations
Administrative Contact
Christine Brunel (Dr.)
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 593 808,94
Address
Norregade 10
1165 Kobenhavn

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Poul Petersen (Prof.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 298 498,22
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
John Woodley (Prof.)
UNIVERSITAT DES SAARLANDES
Germany
EU contribution
€ 234 876,38
Address
Campus
66123 Saarbrucken

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Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cornelia Koeck (Ms.)
LONZA AG
Switzerland
EU contribution
€ 212 752,14
Address
Muenchensteinerstrasse 38
4002 Basel

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Antonio Osorio (Dr.)
ASTRAZENECA AB
Sweden
EU contribution
€ 202 077,71
Address
Vastra Maelarhamnen
151 85 Sodertaelje

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Hayes (Dr.)