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Dietary Fibers supporting Gut and Immune Function
- From polysaccharide compound to health claim

Objective

The project goal is to support the development of functional food ingredients and products that are beneficial for the human gut & immune system and therefore of crucial importance for quality of life. The project will study the effects of specific non-digestible polysaccharides which have shown health potential in this field. The health effects of NPS will be focused around enhancing immune defence against pathogens, the reduction of infectious diseases like common cold and influenza of elderly and will make use of EFSA supported biomarkers that enable immune function claims and underpin the mechanism involved. The studied mechanisms are the innate and adaptive immune system and the possible involvement of the microbiota and microbiota-mediated products. To achieve this goal new and existing NPS will be studied for their health effects in a systematic way by developing a toolbox of dedicated assays and models that can be used by industry and authorities to study and approve food ingredients with a similar health focus. The project will: 1) perform biochemical analyses to study compounds, effect of processing and bioavailability, 2) develop standardized in vitro screening methods to be able to predict in vivo effects, 3) use dedicated in vivo and ex vivo analyses to study mechanisms of action and to validate biomarkers and 4) use and validate this knowledge in an intervention study. By combining the knowledge that will be gained from molecular, cellular and whole-organism studies, the goal will be to understand the bioactive mechanisms of these NPS and use this knowledge to design functional food products. SMEs make a very large contribution to the project, both as beneficiary of the products and as a technology service provider related to health research. This proposed project should provide the scientific basis for international nutritional organisations to recommend an immune-related functional health claim for some of the NPS studied.

Field of science

  • /medical and health sciences/health sciences/infectious disease/RNA virus
  • /natural sciences/biological sciences/biochemistry/biomolecules/carbohydrates
  • /medical and health sciences/basic medicine/immunology

Call for proposal

FP7-KBBE-2011-5
See other projects for this call

Funding Scheme

CP-TP - Collaborative Project targeted to a special group (such as SMEs)

Coordinator

STICHTING WAGENINGEN RESEARCH
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Netherlands
Activity type
Research Organisations
EU contribution
€ 1 017 008
Administrative Contact
Jurriaan Mes (Dr.)

Participants (16)

Agricultural Catchments Programme
Ireland
EU contribution
€ 199 528
Address
Oak Park
R93 Carlow
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Martin Cooney (Dr.)
NOFIMA AS
Norway
EU contribution
€ 440 844
Address
Muninbakken 9-13
9291 Tromso
Activity type
Research Organisations
Administrative Contact
Anne Risbraathe (Ms.)
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 266 757
Address
147 Rue De L'universite
75007 Paris Cedex 07
Activity type
Research Organisations
Administrative Contact
Emilie Briand-Dubreuil (Ms.)
INSTITUT PASTEUR
France
EU contribution
€ 97 440
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
Activity type
Research Organisations
Administrative Contact
Nadia Khelef (Dr.)
CRC CLINICAL RESEARCH CENTER KIEL GMBH
Germany
EU contribution
€ 1 033 902
Address
Schauenburgerstrasse 116
24118 Kiel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Christiane Laue (Dr.)
BIOACTOR BV
Netherlands
EU contribution
€ 233 034
Address
Oxfordlaan 70
6229 EV Maastricht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hans Van Der Saag (Mr.)
SWEDISH OAT FIBER AB
Sweden
EU contribution
€ 225 984
Address
Bua Hamn 6
43024 Varobacka
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Frédéric Prothon (Dr.)
Genetic Analysis AS
Norway
EU contribution
€ 328 509
Address
Nycoveien 2
0485 Oslo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Morten Isaksen (Dr.)
IMMITEC NORGE AS
Norway
EU contribution
€ 129 433
Address
Farmannsveien 18-22
3111 Tonsberg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jan Oddvar Johansen (Mr.)
PRODIGEST
Belgium
EU contribution
€ 417 739
Address
Technologiepark 3
9052 Gent Zwijnaarde
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Sam Possemiers (Dr.)
DE GROOT-WEEVERS PHILIPPUS JOSEPHUS
Netherlands
EU contribution
€ 88 377
Address
Gunninglaan 70
7314NE Apeldoorn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philippus Josephus De Groot (Dr.)
WINCLOVE BIO INDUSTRIES BV
Netherlands
EU contribution
€ 92 800
Address
Hulstweg 11
1032 LB Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Saskia Van Hemert (Dr.)
OREBRO UNIVERSITY
Sweden
EU contribution
€ 597 593
Address
Fakultetsgatan 1
70182 Orebro
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ivarsson Ann-Britt (Ms.)
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
United Kingdom
EU contribution
€ 214 933
Address
King's College Regent Walk
AB24 3FX Aberdeen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ian Tough (Mr.)
WAGENINGEN UNIVERSITY
Netherlands
EU contribution
€ 441 349
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jerry Wells (Prof.)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 149 326
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gastone Castellani (Prof.)