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The discovery, development and demonstration of biocatalysts for use in the industrial synthesis of chiral chemicals

Objective

The objective of KYROBIO project is to broaden the toolbox of single enantiomer chiral chemicals that are produced by industry in Europe using biotechnological routes. The main target is applications of lyase enzymes to selectively synthesize molecules with multiple chiral centres applying enzymatic carbon-carbon and carbon-nitrogen bond formation as the key technical platforms. We will then apply synthetic biology to improve fermentation processes in order to generate better enzymes. Chiral compounds are an important class of chemicals that biocatalytic transformation has already demonstrated great potential to compete with chemocatalysts in their production with associated benefits that come from reductions in use of organic solvents, toxic metals and energy but application has been relatively limited. KYROBIO will address the main challenges with moving forward to the next generation of added value industrial applications of white biotechnology for high value chemical synthesis.
Using a supradisciplinary approach ranging from enzyme development, chemistry, molecular biology, fermentation and innovative isolation techniques the bottlenecks to applying this new technology will be overcome. It is expected that promising candidate chemicals will be commercialised within three years of completion and so scale up with economic and feasibility studies that are also key technology developments.
The consortium includes a strong presence of SMEs including SME leadership and also a large multinational company which ensures multiple routes to market for the outcomes of this project. We will also have economic and life cycle analysis coupled with significant dissemination plans to ensure wider understanding of this technology that will lead to increased acceptance and uptake. The use of this environmentally beneficial technology will help to keep the European chemicals industry at the forefront of white biotechnology and increase opportunities in economic and employment.

Call for proposal

FP7-KBBE-2011-5
See other projects for this call

Funding Scheme

CP-TP - Collaborative Project targeted to a special group (such as SMEs)

Coordinator

C-TECH INNOVATION LIMITED
Address
Capenhurst Technology Park
CH1 6EH Chester
United Kingdom
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 462 513,50
Administrative Contact
Edward Jones (Mr.)

Participants (17)

EVOXX TECHNOLOGIES GMBH
Germany
EU contribution
€ 248 640
Address
Alfred Nobel Strasse 10
40789 Monheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thorsten Eggert (Dr.)
BICT SRL
Italy
EU contribution
€ 189 688
Address
Via Fratelli Sommariva 3
26818 Villanova Del Sillaro
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roberto Verga (Dr.)
INGENZA LIMITED
United Kingdom
EU contribution
€ 361 800
Address
Wallace Building Roslin Biocentre
EH25 9PP Roslin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ian Archer (Dr.)
CLEA TECHNOLOGIES BV
Netherlands
EU contribution
€ 289 649
Address
Delftechpark 34
2628 XH Delft
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ivo Van Der Laan (Mr.)
BIOINFOBANK INSTITUTE
Poland
EU contribution
€ 225 600
Address
Limanowskiego 24/A 16
60744 Poznan
Activity type
Research Organisations
Administrative Contact
Aneta Lis Markiewicz (Ms.)
PROZOMIX LIMITED
United Kingdom
EU contribution
€ 333 253
Address
Station Court 3
NE49 9HN Haltwhistle
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ruth Lloyd (Dr.)
VTU TECHNOLOGY TECHNOLOGIE-ENTWICKLUNGSGESELLSCHAFT MBH
Austria
EU contribution
€ 55 003
Address
Parkring 18
8074 Grambach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thomas Purkarthofer (Dr.)
X-ZYME GMBH
Germany
EU contribution
€ 410 920
Address
Merowingerplatz 1 A
40225 Dusseldorf
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Shukrallah Na'amnieh (Dr.)
BIO-PRODICT BV
Netherlands
EU contribution
€ 216 000
Address
Nieuwe Marktstraat 54
6511 AA Nijmegen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Repke Dobbelsteen (Ms.)
ACIB GMBH
Austria
EU contribution
€ 800 277,50
Address
Krenngasse 37/2
8010 Graz
Activity type
Research Organisations
Administrative Contact
Mathias Drexler (Dr.)
UNIVERSITAET GRAZ
Austria
EU contribution
€ 369 353
Address
Universitatsplatz 3
8010 Graz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Sabine Schwarzl (Ms.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 284 003
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Liz Fay (Ms.)
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 697 085
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jan Poutsma (Mr.)
UNIVERSITY OF STUTTGART
Germany
EU contribution
€ 589 560
Address
Keplerstrasse 7
70174 Stuttgart
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Bettina Nestl (Dr.)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 94 800
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Karsten Reichstein (Mr.)
CHEMISTRY INNOVATION LIMITED

Participation ended

United Kingdom
EU contribution
€ 10 832,34
Address
Burlington House Picadilly
W1J 0BA London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Steven Fletcher (Dr.)
KNOWLEDGE TRANSFER NETWORK LIMITED
United Kingdom
EU contribution
€ 24 325,66
Address
52 Upper Street Suite 218 Business Design Centre Islington
N1 0QH London
Activity type
Other
Administrative Contact
Anna Field (Ms.)