Objective "Using state-of-the-art microsystems simulation, design and micro-engineering, the NMCEL project will result in a highly integrated and modular and low cost platform that is a high throughput micro-fluidic lab-on-a-chip and a sophisticated nuclear magnetic resonance (NMR) detector in one package, suitable for use in a wide-bore commercial NMR magnet. This unique platform targets the controlled in vivo NMR spectroscopy and imaging of the model organism C. elegans, for this purpose the high throughput micro-fluidic lab-on-a-chip has the necessary infrastructure to feed, hold, move and immobilise a large population of C. elegans on demand and over its lifecycle and lifetime, with operations synchronised with the remaining functions of the platform. In turn, the co-integrated NMR detector is specially adapted to the range of shapes of the nematode, and its motility, and is optimised with regard to NMR signal-to-noise ratio and spectral resolution. In order to attain high resolution, the NMR system is optimised for strong magnetic fields, through the computed layout of devices, the adaptation of microstructurable materials, and the design of electronics and control circuits. The targeted user of the platform is a C. elegans micro-biologist with a requirement to detect or discover small molecule (< 1000 Da) metabolites in vivo. High throughput in vivo metabolomic mapping, with a platform that generates molecular data on an individual-by-individual basis for populations of thousands of individuals, has the potential to open up a completely new window of research in systems biology. The NMCEL project aims to address this important step ahead." Fields of science natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidicsengineering and technologyother engineering and technologiesmicrotechnologylab on a chipnatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopy Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-AG-ID1 - ERC Advanced Grant Interdisciplinary Panel Call for proposal ERC-2011-ADG_20110209 See other projects for this call Funding Scheme ERC-AG - ERC Advanced Grant Coordinator KARLSRUHER INSTITUT FUER TECHNOLOGIE Address Kaiserstrasse 12 76131 Karlsruhe Germany See on map Region Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Kronimus Berndt (Dr.) Principal investigator Jan Gerrit Korvink (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Beneficiaries (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all KARLSRUHER INSTITUT FUER TECHNOLOGIE Germany EU contribution € 1 433 403,80 Address Kaiserstrasse 12 76131 Karlsruhe See on map Region Baden-Württemberg Karlsruhe Karlsruhe, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Kronimus Berndt (Dr.) Principal investigator Jan Gerrit Korvink (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Participation ended Germany EU contribution € 1 963 556,20 Address Fahnenbergplatz 79098 Freiburg See on map Region Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Jan Gerrit Korvink (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
