Objective
Alternative splicing (AS) has recently emerged as one of the most important mechanisms for generating proteome diversity and regulating gene expression. It is becoming clear that the majority of human genes encode transcripts that undergo AS, greatly enhancing the coding potential of the genome. Very few examples of alternatively spliced transcripts have been reported in plants and still fewer are known to generate functionally distinct proteins. However, the recent explosive growth of available expressed sequence data and its alignment with genomic sequences indicates that AS plays a far more important role in plants than previously thought, and further work is necessary to uncover the significance and regulation of this process.
The unique developmental plasticity and stress tolerance developed by plants as a result of their sessile growth habit suggests that they offer exceptional opportunities to reveal AS mechanisms, which are likely to play a key role in the adaptation of plants to changes in their environment. This project will investigate both the biological relevance of AS in plant development and stress responses and the regulatory mechanisms of plant pre-mRNA splicing about which virtually nothing is known.
The functional significance of different splice variants of specific development- and stress-associated genes will be examined using reverse genetic approaches in Arabidopsis thaliana. Moreover, the function of individual serine/arginine-rich (SR) proteins, which are established key players in mammalian AS, and their stress-specific expression patterns will be analysed. A computational approach will also be employed to identify plant splicing enhancercis-acting elements (ESEs) recognized by SR proteins. This work deals with an exciting area of plant biology and will accelerate understanding of the molecular mechanisms underlying plant adaptation to environmental stress, opening new avenues for the use of biotechnology to increase plant productivity.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- social sciences economics and business economics production economics productivity
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
- natural sciences chemical sciences organic chemistry aliphatic compounds
- natural sciences biological sciences genetics genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
LISBOA
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.