Skip to main content

Tailoring Enzymes for Natural Product Synthesis

Objective

The aim of the project is to translate the knowledge from biosynthetic pathways of natural products into Organic Chemistry, achieved by developing novel chemoenzymatic total syntheses of the polyketide natural products ambruticin and jerangolid. In both biosynthetic pathways, large parts of the molecular complexity are set up by tailoring enzymes. These enzymes will be studied regarding their potential to act as biocatalysts that can substitute late and crucial steps in total syntheses.
The project divides into two parts. At first, the biosynthesis of ambruticin and jerangolid will be studied with a focus on allocating particular steps to individual tailoring enzymes. These enzymes will be characterised in in vitro assays and these assays will be optimised in order to find out if the candidate enzymes can be applied as efficient biocatalysts. After this, total syntheses will be developed, which integrate these enzymatic steps. This approach promises to gain several advantages. The overall efficiency of the syntheses could be drastically improved and the access to derivatives could also be considerably facilitated. Furthermore, the project will gain substantial knowledge about tailoring processes of complex polyketide pathways.

Field of science

  • /natural sciences/chemical sciences/organic chemistry
  • /engineering and technology/industrial biotechnology/bioprocessing technologies/biocatalysis
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

FP7-PEOPLE-2011-CIG
See other projects for this call

Funding Scheme

MC-CIG - Support for training and career development of researcher (CIG)

Coordinator

GOTTFRIED WILHELM LEIBNIZ UNIVERSITAET HANNOVER
Address
Welfengarten 1
30167 Hannover
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 100 000
Administrative Contact
Monika Griese (Ms.)