Objective
The SysGen of Obesity project aims to use the pig as an animal model to unravel genes affecting human obesity, metabolic syndrome and diabetes (OMSD) traits and to catalogue their functional and molecular interactions and biological pathways. It uses state-of-the-art technologies and analytical approaches. The animal model uses a pig population of over 500 third generation progeny derived from crossing very divergent parental breeds (lean and fatty). It thus provides a very powerful design to map genes affecting OMSD. The resource population will be phenotyped for many traits including blood profiles known to be relevant to OMSD. Genotyping will be based on the Porcine 60k Illumina SNPchip. Gene or quantitative trait locus (QTL) mapping and genome-wide association studies (GWAS) will be conducted to detect genes and variants affecting OMSD traits. These genes will subsequently be validated for biological relevance using systems genetics approaches. They will also be screened for concordance with human QTL-GWAS results by comparative genomics. The most significant genes from the above steps could harbour relevant causal genes/mutations and hence will be selected for targeted resequencing and further analyses. This animal model is also expected to find 'novel' genes and pathways that have not been identified previously in human obesity. Systems biology experiment is planned using a ‘BioBank’ of relevant tissues and RNA samples from this resource population. The ultimate impact will be in the form of delivery of potential causal mutations, biological pathways, genetic- and bio-markers and new drug targets to improve human health. Hence our project will enhance EU excellence in Genetics and Systems Biology of OMSD and strengthen EU bio-medical industry. This grant will give an excellent opportunity for the researcher to conduct this high profile research thereby integrating him in EU scientific community and will significantly enhance his long-term career prospects
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics RNA
- medical and health sciences health sciences nutrition obesity
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.