Skip to main content

Metabolomics of fungal diseases: a systems biology approach for biomarkers discovery and therapy

Publicaciones

Aryl hydrocarbon receptor control of a disease tolerance defence pathway

Autores: Bessede, Alban; Gargaro, Marco; Pallotta, Maria T.; Matino, Davide; Servillo, Giuseppe; Brunacci, Cinzia; Bicciato, Silvio; Mazza, Emilia M. C.; Macchiarulo, Antonio; Vacca, Carmine; Iannitti, Rossana; Tissi, Luciana; Volpi, Claudia; Belladonna, Maria L.; Orabona, Ciriana; Bianchi, Roberta; Lanz, Tobias V.; Platten, Michael; Della Fazia, Maria A.; Piobbico, Danilo; Zelante, Teresa; Funakoshi, Hiroshi; Nakamura, Toshikazu; Gilot, David; Denison, Michael S.; Guillemin, Gilles J.; DuHadaway, James B.; Prendergast, George C.; Metz, Richard; Geffard, Michel; Boon, Louis; Pirro, Matteo; Iorio, Alfonso; Veyret, Bernard; Romani, Luigina; Grohmann, Ursula; Fallarino, Francesca; Puccetti, Paolo
Publicado en: HAL CCSD Nature, vol 511, iss 7508 2014
Identificador permanente: Digital Object Identifier:10.1038/nature13323; PubMed Central ID:PMC4098076; PubMed ID:24930766

Towards Targeting the Aryl Hydrocarbon Receptor in Cystic Fibrosis

Autores: Puccetti, Matteo; Paolicelli, Giuseppe; Oikonomou, Vasileios; De Luca, Antonella; Renga, Giorgia; Borghi, Monica; Pariano, Marilena; Stincardini, Claudia; Scaringi, Lucia; Giovagnoli, Stefano; Ricci, Maurizio; Romani, Luigina; Zelante, Teresa
Publicado en: Hindawi Limited 2018
Identificador permanente: Digital Object Identifier:10.1155/2018/1601486; PubMed Central ID:PMC5835240; PubMed ID:29670460

IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut.

Autores: Marco De Zuani; Valeria Raia; Silvia Moretti; Valeria Rachela Villella; Angelo Sidoni; Monia Baldoni; Giorgia Renga; Luigina Romani; Giuseppe Paolicelli; Monica Borghi; Andrea Bartoli; Luigi Maiuri; Luigi Maiuri; Enrico Garaci; Carlo Pucillo; Jean-Christophe Renauld; Claudio Costantini; Rachele Del Sordo; Teresa Zelante; Vasilis Oikonomou
Identificador permanente: Handle:2078.1/229244; Digital Object Identifier:10.1016/j.celrep.2018.04.034; PubMed Central ID:PMC5976578; PubMed ID:29742432

Autophagy and LAP in the Fight against Fungal Infections: Regulation and Therapeutics

Autores: Oikonomou, Vasileios; Renga, Giorgia; De Luca, Antonella; Borghi, Monica; Pariano, Marilena; Puccetti, Matteo; Paolicelli, Giuseppe; Stincardini, Claudia; Costantini, Claudio; Bartoli, Andrea; Zelante, Teresa; Romani, Luigina
Identificador permanente: Digital Object Identifier:10.1155/2018/6195958; PubMed Central ID:PMC5859860; PubMed ID:29692681

Antifungal Th Immunity: Growing up in Family

Autores: Luigina Romani; Melissa Palmieri; Claudia Galosi; Vasileios Oikonomou; Andrea Bartoli; Monica Borghi; Matteo Puccetti; Giorgia Renga
Publicado en: Frontiers Media SA Frontiers in Immunology 2014
Identificador permanente: Digital Object Identifier:10.3389/fimmu.2014.00506; PubMed Central ID:PMC4197763; PubMed ID:25360137

PTX3 Binds MD-2 and Promotes TRIF-Dependent Immune Protection in Aspergillosis

Autores: Bozza, S.; Campo, S.; Arseni, B.; Inforzato, A.; Ragnar, L.; Bottazzi, B.; Mantovani, A.; Moretti, S.; Oikonomous, V.; De Santis, R.; Carvalho, A.; Salvatori, G.; Romani, L.
Publicado en: The American Association of Immunologists 2014
Identificador permanente: Digital Object Identifier:10.4049/jimmunol.1400814

A Reappraisal of Thymosin Alpha1 in Cancer Therapy

Autores: Allan L. Goldstein; Giorgia Renga; Marina M. Bellet; Enrico Garaci; Claudio Costantini; Marilena Pariano; Claudia Stincardini; Luigina Romani
Publicado en: Frontiers Media S.A. Frontiers in Oncology, Vol 9 (2019) 2019
Identificador permanente: PubMed Central ID:PMC6742685; PubMed ID:31555601; Digital Object Identifier:10.3389/fonc.2019.00873

Thymosin α1 represents a potential potent single-molecule-based therapy for cystic fibrosis

Autores: Romani, Luigina; Oikonomou, Vasilis; Moretti, Silvia; Iannitti, Rossana G; D'Adamo, Maria Cristina; Villella, Valeria R; Pariano, Marilena; Sforna, Luigi; Borghi, Monica; Bellet, Marina M; Fallarino, Francesca; Pallotta, Maria Teresa; Servillo, Giuseppe; Ferrari, Eleonora; Puccetti, Paolo; Kroemer, Guido; Pessia, Mauro; Maiuri, Luigi; Goldstein, Allan L; Garaci, Enrico
Publicado en: Springer Science and Business Media LLC Nature medicine 2017
Identificador permanente: Digital Object Identifier:10.1038/nm.4305; PubMed Central ID:PMC5420451; PubMed ID:28394330

Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease.

Autores: Renga, Giorgia; Oikonomou, Vasilis; Moretti, Silvia; Stincardini, Claudia; Bellet, Marina M; Pariano, Marilena; Bartoli, Andrea; Brancorsini, Stefano; Mosci, Paolo; Finocchi, Andrea; Rossi, Paolo; Costantini, Claudio; Garaci, Enrico; Goldstein, Allan L; Romani, Luigina
Publicado en: Life Science Alliance, LLC 2019
Identificador permanente: Digital Object Identifier:10.26508/lsa.201900432; PubMed Central ID:PMC6851533; PubMed ID:31719116

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

Autores: Zelante, Teresa; Iannitti, Rossana G.; Cunha, Cristina; De Luca, Antonella; Giovannini, Gloria; Pieraccini, Giuseppe; Zecchi, Riccardo; D’Angelo, Carmen; Massi-Benedetti, Cristina; Fallarino, Francesca; Carvalho, Agostinho; Puccetti, Paolo; Romani, Luigina
Publicado en: Elsevier BV 2013
Identificador permanente: Digital Object Identifier:10.1016/j.immuni.2013.08.003

Molecular surveillance of healthcare-associated Candida infections in a rehabilitation center for patients with severe acquired brain injuries

Autores: Scordino, F; Galeano, G; Orlando, Mg; Barberi, G; Giosa, D; Giuffre, L; Merlo, Fm; Criseo, G; Romeo, O
Publicado en: OXFORD UNIV PRESS Array 2018

Intravenous immunoglobulin protects from experimental allergic bronchopulmonary aspergillosis via a sialylation-dependent mechanism

Autores: Bozza, Silvia; Käsermann, Fabian; Kaveri, Srini V; Romani, Luigina; Bayry, Jagadeesh
Publicado en: Wiley European Journal of Immunology, Wiley-VCH Verlag, 2019, 49 (1), pp.195-198. ⟨10.1002/eji.201847774⟩ 2019
Identificador permanente: Digital Object Identifier:10.1002/eji.201847774

The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface.

Autores: Costantini, Claudio; Renga, Giorgia; Oikonomou, Vasilis; Paolicelli, Giuseppe; Borghi, Monica; Pariano, Marilena; De Luca, Antonella; Puccetti, Matteo; Stincardini, Claudia; Mosci, Paolo; Bartoli, Andrea; Zelante, Teresa; Romani, Luigina
Publicado en: Hindawi Limited 2018
Identificador permanente: Digital Object Identifier:10.1155/2018/7396136; PubMed Central ID:PMC6230381; PubMed ID:30510489

A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease.

Autores: Villella, Valeria R; Venerando, Andrea; Cozza, Giorgio; Esposito, Speranza; Ferrari, Eleonora; Monzani, Romina; Spinella, Mara C; Oikonomou, Vasilis; Renga, Giorgia; Tosco, Antonella; Rossin, Federica; Guido, Stefano; Silano, Marco; Garaci, Enrico; Chao, Yu‐Kai; Grimm, Christian; Luciani, Alessandro; Romani, Luigina; Piacentini, Mauro; Raia, Valeria; Kroemer, Guido; Maiuri, Luigi
Publicado en: EMBO The EMBO Journal 2019
Identificador permanente: Digital Object Identifier:10.15252/embj.2018100101; PubMed Central ID:PMC6331719; PubMed ID:30498130

Tryptophan Co-Metabolism at the Host-Pathogen Interface.

Autores: Barbara Cellini; Claudia Stincardini; Monica Borghi; Luigina Romani; Giorgia Renga; Nancy P. Keller; Claudio Costantini; Marilena Pariano; Marina M. Bellet; Teresa Zelante
Identificador permanente: PubMed Central ID:PMC7001157; PubMed ID:32082324; Digital Object Identifier:10.3389/fimmu.2020.00067

Cellular proteostasis: a new twist in the action of thymosin α1.

Autores: Stincardini, Claudia; Renga, Giorgia; Villella, Valeria; Pariano, Marilena; Oikonomou, Vasilis; Borghi, Monica; Bellet, Marina M.; Sforna, Luigi; Costantini, Claudio; Goldstein, Allan L.; Garaci, Enrico; Romani, Luigina
Publicado en: Informa UK Limited 2018
Identificador permanente: Digital Object Identifier:10.1080/14712598.2018.1484103

Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1.

Autores: Oikonomou, V; Moretti, S; Renga, G; Galosi, C; Borghi, M; Pariano, M; Puccetti, M; Palmerini, CA; Amico, L; Carotti, A; Prezioso, L; Spolzino, A; Finocchi, A; Rossi, P; Velardi, A; Aversa, F; Napolioni, V; Romani, L

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

Autores: Iannitti, R.G.; Napolioni, V.; Oikonomou, V.; De Luca, A.; Galosi, C.; Pariano, M.; Massi Benedetti, C.; Borghi, M.; Puccetti, M.; Lucidi, V.; Colombo, C.; Fiscarelli, E.; Lass Flà ¶ rl, C.; Majo, F.; Cariani, L.; Russo, M.; Porcaro, L.; Ricciotti, G.; Ellemunter, H.; Ratclif, L.; De Benedictis, F.M.; Talesa, V.N.; Dinarello, C.A.; Van De Veerdonk, F.L.; Romani, L.
Publicado en: Springer Science and Business Media LLC Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016) 2016
Identificador permanente: Digital Object Identifier:10.1038/ncomms10791; PubMed Central ID:PMC4793079; PubMed ID:26972847; Handle:2066/172723

Host and Microbial Tryptophan Metabolic Profiling in Multiple Sclerosis.

Autores: Giuseppe Pieraccini; Lorenzo Gaetani; Luigina Romani; Paolo Calabresi; Massimiliano Di Filippo; Francesca Boscaro; Teresa Zelante
Identificador permanente: PubMed Central ID:PMC7041364; PubMed ID:32132996; Digital Object Identifier:10.3389/fimmu.2020.00157

From memory to antifungal vaccine design.

Autores: Rossana G. Iannitti; Luigina Romani; Agostinho Carvalho; Agostinho Carvalho
Publicado en: Elsevier BV 2012
Identificador permanente: Digital Object Identifier:10.1016/j.it.2012.04.008; Handle:1822/67419

T cell responses in fungal infections

Autores: Cunha C; Aversa F; Romani L; Carvalho A.

The Intestinal Mycobiota of Nero Siciliano Pig

Autores: Giuffre, L; Sapienza, I; Criseo, G; Romeo, O; D'Alessandro, E
Publicado en: OXFORD UNIV PRESS Array 2018

Immune resistance and tolerance to fungi

Autores: Romani Luigina

Biochemical Characterization of Aspergillus fumigatus AroH, a Putative Aromatic Amino Acid Aminotransferase.

Autores: Mirco Dindo; Egidia Costanzi; Marco Pieroni; Claudio Costantini; Giannamaria Annunziato; Agostino Bruno; Agostino Bruno; Nancy P. Keller; Luigina Romani; Teresa Zelante; Barbara Cellini
Publicado en: Frontiers Media S.A. 2018
Identificador permanente: Digital Object Identifier:10.3389/fmolb.2018.00104; PubMed Central ID:PMC6279937; PubMed ID:30547035

Microbiota control of a tryptophan-AhR pathway in disease tolerance to fungi

Autores: Romani, Luigina; Zelante, Teresa; Luca, Antonella De; Iannitti, Rossana G.; Moretti, Silvia; Bartoli, Andrea; Aversa, Franco; Puccetti, Paolo

IL-9 Integrates the Host-Candida Cross-Talk in Vulvovaginal Candidiasis to Balance Inflammation and Tolerance.

Autores: Andrea Bartoli; Vasileios Oikonomou; Paolo Mosci; Giorgia Renga; Luigina Romani; Jean-Christophe Renauld; Monica Borghi; Claudio Costantini
Publicado en: Frontiers Media S.A. Frontiers in Immunology 2018
Identificador permanente: PubMed Central ID:PMC6255860; Digital Object Identifier:10.3389/fimmu.2018.02702; Handle:2078.1/229243

A mast cell-ILC2-Th9 pathway promotes lung inflammation in cystic fibrosis

Autores: Luigina Romani; Giorgia Renga; Carlo Pucillo; Jean-Christophe Renauld; Ersilia Fiscarelli; Marilena Pariano; Rossana G. Iannitti; Silvia Moretti; Vincenzina Lucidi; Vincenzo Nicola Talesa; Giuseppe Paolicelli; Valerio Napolioni; Carla Colombo; Helmut Ellemunter; Marco De Zuani; Oxana Bereshchenko; Paolo Sportoletti; Gabriella Ricciotti; Cornelia Lass-Flörl; Matteo Puccetti; Monica Borghi; Fabio Majo; Luigi Ratclif; Maria Chiara Russo; Teresa Zelante; Vasilis Oikonomou; Claudia Galosi
Publicado en: Nature Publishing Group Nature Communications, Vol. 8, no.0, p. 14017 (2017) 2017
Identificador permanente: Handle:2078.1/184339; Digital Object Identifier:10.1038/ncomms14017; PubMed Central ID:PMC5241810; PubMed ID:28090087

Tryptophan Feeding of the IDO1-AhR Axis in Host–Microbial Symbiosis

Autores: Zelante, Teresa; Iannitti, Rossana Giulietta; Fallarino, Francesca; Gargaro, Marco; De Luca, Antonella; Moretti, Silvia; Bartoli, Andrea; Romani, Luigina
Publicado en: Frontiers Media S.A. Frontiers in Immunology 2014
Identificador permanente: PubMed Central ID:PMC4266093; PubMed ID:25566253; Digital Object Identifier:10.3389/fimmu.2014.00640

Noncanonical Fungal Autophagy Inhibits Inflammation in Response to IFN-γ via DAPK1.

Autores: Oikonomou, Vasilis; Moretti, Silvia; Renga, Giorgia; Galosi, Claudia; Borghi, Monica; Pariano, Marilena; Puccetti, Matteo; Palmerini, Carlo A.; Amico, Lucia; Carotti, Alessandra; Prezioso, Lucia; Spolzino, Angelica; Finocchi, Andrea; Rossi, Paolo; Velardi, Andrea; Aversa, Franco; Napolioni, Valerio; Romani, Luigina
Publicado en: Elsevier BV Cell Host & Microbe 2016
Identificador permanente: PubMed Central ID:PMC5161749; PubMed ID:27889463; Digital Object Identifier:10.1016/j.chom.2016.10.012

Regulation of host physiology and immunity by microbial indole-3-aldehyde.

Autores: Stefano Giovagnoli; Luigina Romani; Matteo Puccetti; Teresa Zelante
Publicado en: Elsevier BV 2021
Identificador permanente: Digital Object Identifier:10.1016/j.coi.2020.12.004

Association of a variable number tandem repeat in the NLRP3 gene in women with susceptibility to RVVC.

Autores: Jaeger M; Carvalho A; Cunha C; Ts, Plantinga; van de Veerdonk F; Puccetti M; Galosi C; La, Joosten; Dupont B; Bj, Kullberg; Jd, Sobel; Luigina Romani; Mg, Netea
Publicado en: Springer Nature VOLUME=35;STARTPAGE=797;ENDPAGE=801;ISSN=0934-9723;TITLE=European Journal of Clinical Microbiology and Infectious Diseases 2016
Identificador permanente: Digital Object Identifier:10.1007/s10096-016-2600-5; Handle:2066/171893; PubMed Central ID:PMC4840230; PubMed ID:26951262

Genetic polymorphisms affecting IDO1 or IDO2 activity differently associate with aspergillosis in humans

Autores: Napolioni, V.; Pariano, M.; Borghi, M.; Oikonomou, V.; Galosi, C.; De Luca, A.; Stincardini, C.; Vacca, C.; Renga, G.; Lucidi, V.; Colombo, C.; Fiscarelli, E.; Lass-Florl, C.; Carotti, A.; D' Amico, L.; Majo, F.; Russo, M.C.; Ellemunter, H.; Spolzino, A.; Mosci, P.; Brancorsini, S.; Aversa, F.; Velardi, A.; Romani, L.; Costantini, C.
Publicado en: Frontiers Media Frontiers in Immunology, Vol 10 (2019) 2019
Identificador permanente: Digital Object Identifier:10.3389/fimmu.2019.00890; PubMed Central ID:PMC6514051; PubMed ID:31134053

Targeting the Aryl Hydrocarbon Receptor With Indole-3-Aldehyde Protects From Vulvovaginal Candidiasis via the IL-22-IL-18 Cross-Talk

Autores: Stefano Brancorsini; Paolo Mosci; Carmine Vacca; Matteo Puccetti; Monica Borghi; Claudio Costantini; Valentina Solito; Giorgia Renga; Federica Sellitto; Marilena Pariano; Marina M. Bellet; Luigina Romani; Claudia Stincardini
Identificador permanente: PubMed Central ID:PMC6798081; PubMed ID:31681274; Digital Object Identifier:10.3389/fimmu.2019.02364

Cystic fibrosis transmembrane conductance regulator (CFTR) and autophagy: hereditary defects in cystic fibrosis versus gluten-mediated inhibition in celiac disease

Autores: Maiuri, L.; Raia, V.; Piacentini, M.; Antonella TOSCO; Villella, V. R.; Kroemer, G.
Publicado en: Impact Journals LLC Scopus - Elsevier 2019
Identificador permanente: PubMed Central ID:PMC6633896; PubMed ID:31321000

Small Molecule CCR4 Antagonists Protect Mice from Aspergillus Infection and Allergy

Autores: Rossana G. Iannitti; Luigina Romani; Giorgia Renga; Silvia Bozza; Jagadeesh Bayry; Claudio Costantini; Marilena Pariano
Publicado en: HAL CCSD Biomolecules, Vol 11, Iss 351, p 351 (2021) 2021
Identificador permanente: PubMed Central ID:PMC7996545; PubMed ID:33669094; Digital Object Identifier:10.3390/biom11030351

Immunity and tolerance to fungi in hematopoietic transplantation: principles and perspectives

Autores: Agostinho eCarvalho; Agostinho eCarvalho; Agostinho eCarvalho; Cristina eCunha; Silvia eBozza; Silvia eMoretti; Cristina eMassi-Benedetti; Francesco eBistoni; Franco eAversa; Luigina eRomani
Publicado en: Frontiers Media SA Frontiers in Immunology 2012
Identificador permanente: Digital Object Identifier:10.3389/fimmu.2012.00156; Handle:1822/23814; PubMed Central ID:PMC3374351; PubMed ID:22707953

IL-37 Inhibits Inflammasome Activation and Disease Severity in Murine Aspergillosis

Autores: Silvia Moretti; Silvia Bozza; Vasilis Oikonomou; Giorgia Renga; Andrea Casagrande; Rossana G Iannitti; Matteo Puccetti; Cecilia Garlanda; Soohyun Kim; Suzhao Li; Frank L van de Veerdonk; Charles A Dinarello; Luigina Romani
Identificador permanente: Handle:2066/138896; Digital Object Identifier:10.1371/journal.ppat.1004462; PubMed Central ID:PMC4223056; PubMed ID:25375146

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

Autores: De Luca, A.; Smeekens, S.P.; Smeekens, S.P.; Smeekens, S.P.; Casagrande, A.; Iannitti, R.; Conway, K.L.; Gresnigt, M.S.; Gresnigt, M.S.; Begun, J.; Plantinga, T.S.; Plantinga, T.S.; Joosten, L.A.B.; Joosten, L.A.B.; Joosten, L.A.B.; van der Meer, J.W.M.; van der Meer, J.W.M.; Chamilos, G.; Netea, M.G.; Netea, M.G.; Xavier, R.J.; Dinarello, C.A.; Dinarello, C.A.; Romani, L.; van de Veerdonk, F.L.; van de Veerdonk, F.L.
Identificador permanente: Digital Object Identifier:10.1073/pnas.1322831111; PubMed Central ID:PMC3948220; PubMed ID:24550444; Handle:2066/138198

Genetic PTX3 Deficiency and Aspergillosis in Stem-Cell Transplantation

Autores: Cunha C; Aversa F; Lacerda JF; Busca A; Kurzai O; Grube M; Lxf6ffler J; Maertens JA; Bell AS; Inforzato A; Barbati E; Almeida B; Santos e Sousa P; Barbui A; Potenza L; Caira M; Rodrigues F; Salvatori G; Pagano L; Luppi M; Mantovani A; Velardi A; Romani L; Carvalho A.
Publicado en: Massachusetts Medical Society New England Journal of Medicine; Vol 370 2014
Identificador permanente: Handle:1822/29240; Digital Object Identifier:10.1056/nejmoa1211161; Handle:11380/1066045