Skip to main content

Non-muscle Myosin II orchestrates the inflammatory response by integrating adhesive and cytokine signaling and the mechanical properties of the inflammatory microenvironment


This research aims to understand how inflammatory cues regulate the cellular responses of different cells implicated in inflammation. The main hypothesis is that non-muscle myosin II (NMII) is a central integrator of the different types of extracellular signals produced during the inflammatory response. The precise goal of the present proposal is to understand the regulation and function of the three NMII isoforms in the migration of cells implicated in inflammation, chiefly blood immune cells and cells that drive tissue repair and remodelling (fibroblasts) and vascularization (endothelial cells). This research will address the following objectives: 1) Identify specific kinases, phosphatases and regulatory sites that regulate NMII activation and assembly in a cell type-, stimulus-, isoform- and spatiotemporal-dependent manner. 2) Determine the signalling events and pathways through which the NMII isoforms control the response to inflammatory cues. 3) Elucidate whether the differences in expression and regulation of NMII underlie the different roles of these cells during inflammation. Successful completion of these objectives will provide novel insights on the basic cellular mechanisms of inflammation and bears potential to identify new therapeutic targets.

Call for proposal

See other projects for this call


Calle Einstein 3 Ciudad Univ Cantoblanco Rectorado
28049 Madrid

See on map

Activity type
Higher or Secondary Education Establishments
Administrative Contact
Mª Carmen Puerta (Ms.)
EU contribution
€ 100 000