Objective The human crystalline lens has the capability to dynamically change its shape to focus near and far objects. By age 55, the accommodation capability is lost and optical aids are needed for near vision. Many questions remain open that are critical to understand accommodation, the failure in presbyopia, and the prospects for its correction. Multifocal presbyopic corrections are increasingly used. However, the ideal multifocal pattern, and the optical factors affecting depth-of-focus and adaptation to simultaneous vision remain to be elucidated. The most satisfactory treatment of presbyopia should rely on the restoration of the dynamic and continuous focusing ability of the eye, and this could be achieved in the form of accommodative intraocular lenses (IOLs). Current approaches, relying on potential IOL axial shifts, have proved little effective accommodative amplitude.The project will seek in nature innovative solutions to treat presbyopia. Deeper understanding of the crystalline lens changes with dynamic accommodation and aging will be gained. Novel imaging techniques will be developed and used to assess the dynamic changes of crystalline lens structure, gradient index distribution and microscopic structure of the lens fibers and capsule. In addition, the treatment of presbyopia by multifocal corrections will be explored. Wavefront sensing and optical coherence tomography will be used to understand the bases for the multifocality found in some animal species (as possible inspiration for multifocal patterns), and adaptive optics and visual simulation to understand the reasons for the limited performance of current multifocal treatments, to investigate neural adaptation to the blur in simultaneous vision and to test the proposed new multifocal patterns. Finally, the understanding of the crystalline lens properties and the biomechanics of the implanted IOLs gained in the project will allow to develop a first prototype of crystalline-lens mimicking accommodative IOL. Fields of science engineering and technologymaterials engineeringfibersmedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVnatural sciencesphysical sciencesopticsnatural sciencesbiological sciencesbiophysics Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-AG-LS7 - ERC Advanced Grant - Diagnostic tools, therapies and public health Call for proposal ERC-2011-ADG_20110310 See other projects for this call Funding Scheme ERC-AG - ERC Advanced Grant Host institution AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS EU contribution € 2 332 229,00 Address CALLE SERRANO 117 28006 Madrid Spain See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Guillermo Sanjuanbenito Garcia (Mr.) Principal investigator Susana Marcos Celestino (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Beneficiaries (3) Sort alphabetically Sort by EU Contribution Expand all Collapse all AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 2 332 229,00 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Guillermo Sanjuanbenito Garcia (Mr.) Principal investigator Susana Marcos Celestino (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACION JIMENEZ DIAZ UTE Participation ended Spain EU contribution No data Address Avda Reyes Catolicos 2 28040 MADRID See on map Activity type Research Organisations Administrative Contact Verónica García Martínez (Ms.) Links Contact the organisation Opens in new window Total cost No data INSTITUTO INVESTIGACION SANITARIA FUNDACION JIMENEZ DIAZ Spain EU contribution € 67 319,00 Address AVENIDA DE LOS REYES CATOLICOS 2 28040 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Verónica Garcia Martínez Links Contact the organisation Opens in new window Website Opens in new window Total cost No data