Objective
"The impact of a globally ageing population cannot be overstated. It is expected that by the year 2025 over a billion individuals will be over 60 years of age. In order to develop strategies aimed to restore and maintain function in ageing individuals, a better understanding of the molecular pathways and biological processes that are involved in ageing and age-related disorders is urgently needed. One of the major mechanisms implicated in the decline of tissue function and ageing is the loss of tissue stem cells. This proposal is aimed at developing a better understanding of two fundamental aspects of stem cell biology: the molecular mechanisms that regulate self-renewal and differentiation and the role of telomere attrition and numerical chromosomal abnormalities in stem cell depletion. For both areas we propose to take advantage of recent improvements in DNA sequencing technology. The first area of interest is the role of sister chromatids in parental (stem) cells on gene expression in daughter cells. For such studies we have developed DNA sequencing techniques that allow identification of specific sister chromatids in single daughter cells using parental DNA template strand sequences. Studies in this area will address an aspect of cell biology that has not been subject to direct experimentation before. For studies on the role of telomere attrition and numerical chromosomal abnormalities in ageing we will use material from humans participating in the LifeLines project in Groningen (160,000 individuals) as well as suitable mouse models. Such studies will employ novel single cell sequencing techniques and telomere length measurements. We are specifically interested to measure telomere dysfunction and aneuploidy in stem cells and more differentiated cells, to identify genetic and other factors regulating human leukocyte telomere length and to study the role of telomere attrition in various leukocytes in relation to normal human ageing and pathology."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences cell biology
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences basic medicine pathology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2011-ADG_20110310
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
9713 GZ Groningen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.