Final Report Summary - KHCCBIO (Supporting the Establishment of a Cancer Biobank for Jordan and its Neighbouring Countries Through Knowledge Transfer & Training)
Executive Summary:
King Hussein Cancer (KHCC) is a non-governmental and not-for-profit, specialized cancer centre in the Middle East that treats both adult and pediatric cancer patients from Jordan and the neighboring countries. KHCC is acknowledged as a leader in cancer treatment in the Middle East and its mission and vision is to maintain its leading position in cancer therapy . Hence, it embarked on establishing the first ISO accredited cancer biobank (KHCCBIO) for the purpose of collecting, processing, storing and distribution of cancer biospecimens that can help in the clarifying the disease cause and its effective treatment.
Currently, there are no or very few biobanks in the Middle East. However, KHCC changed this situation by establishing an ISO-compliant biospecimen repository (KHCCBIO) which incorporated all current international guidelines and best-in class practices under an approved quality management system to procure, process and store biospecimens for the benefit of researchers in Jordan, its neighboring countries, European researchers and researchers throughout the rest of the world. KHCCBIO bank follows the highest ethical standards in collecting, processing, storing and distributing these high-quality, clinically annotated biospecimens by consenting patients prior to collecting these samples and protect patients' rights and confidentiality.
KHCCBIO project was a 30 month project which started on 15/11/2011. KHCCBIO grant agreement was signed on the 29th of February 2012 and the EU pre-financing was received on March 19, 2012. Nevertheless; work started by holding the Kickoff meeting in November 19, 2011, as originally scheduled.
In brief, KHCCBIO bank approach is based on knowledge transfer between organizations and individuals from Europe and Jordan, in existing technological innovation and internationally recognized quality standards. Training courses on consent for tissue banking, procurement, processing and preservation was conducted by Trinity College Dublin , a college specialized in the management of thoracic malignancies. Training in ISO quality management, equipment and systems infrastructure qualification, tissue storage and distribution standards was executed by Biostόr Ireland, a fully accredited and EU-licensed tissue establishment. Future aims of the KHCCBIO support action are to develop KHCC’s research infrastructure, increasing its scope and visibility and improve its competitiveness throughout the European and worldwide biomedical science arena. Establish a platform for future knowledge transfer and collaborative research. Develop and enhance partnerships between European and Middle Eastern organizations for future staff exchanges, seminars and conferences focused on cancer. Disseminating KHCCBIO progress and activities particularly with EU early lung cancer (EUELC) collaborators to ensure the greatest impact and build competency in order to facilitate the participation of KHCC in future EU-calls.
Project Context and Objectives:
The main overall objective for the entire project period was to develop a biobank at KHCC for the purpose of collecting, processing, storing and distributing high-quality, clinically annotated biospecimens from consented patients that is compliant with international standards.
Description of the work performed and the main results achieved during the project were as follows.
WP 1: Coordinating Support Activities & Managing Project. KHCC successfully managed the KHCCBIO project throughout the project and took over the entire management part.
KHCC supervised and managed the achievement of the contractual deliverables and the milestones according to defined deadlines and submitted all scientific/technical reports on time. KHCC guaranteed prompt responses and disseminated information provided by the European Commission to the partners and arranged for telecons and webinars. Monitored work plan and partners activities and followed up on deliverables and sent reminders about work plan and progress to partners. Managed communication among partners and prepared a presentation on the project status and compiled a cost statement for the Technical Review at a project review meeting that was held in Brussels. KHCC was also responsible for the overall financial management of the KHCCBIO project whereas all partners are solely responsible for their own budgets and KHCC distributed the EC contribution to all partners according to the payment scheme laid down in the CA.
WP 2: Implementing Quality Measures. An ISO Quality Management System was established for KHCCBIO to operate according to it. Validation and Training Plans were written by KHCCBIO staff; reviewed & revised by KHCCBIO chief quality officer and deputy director and approved by KHCCBIO director.
WP 3: Supporting Policy Development. During the project period patient consenting policies, and forms for Consenting were written and approved for Ethics Application for Biobanking. Policies on Data Privacy & Confidentiality and Material Transfer Agreements, MTA’s policies were written to define rules for access to the bio-resource, ownership of biological samples and to ensure the highest standards of ethics and governance. KHCCBIO-Biobanking Bylaws were also written and approved. KHCCBIO staff was trained on the consenting process.
WP 4: Harmonising Sampling. SOP’s for the Procurement, Processing, Preservation and Disposal of blood and human tissue samples, based on existing Biobanking SOP’s in use within the Thoracic Oncology Biobank at TCD, in conjunction with international standards were written by KHCCBIO staff; reviewed & revised by KHCCBIO chief quality officer and deputy director and approved by KHCCBIO director then implemented by KHCCBIO staff.
WP 5: Assisting Verification. Installation Qualification (IQ) and Operation Qualification (OQ) protocols and draft Report formats for the identified equipment and systems from their existing Biostór QMS were adapted by KHCCBIO written by KHCCBIO staff; reviewed & revised by KHCCBIO chief quality officer and deputy director and approved by KHCCBIO director then implemented by KHCCBIO newly trained staff.
WP 6: Banking & Collaborating. SOPs for Thoracic tissue & associated blood sample storage and distribution were adapted by KHCCBIO written by KHCCBIO staff; reviewed & revised by KHCCBIO chief quality officer and deputy director and approved by KHCCBIO director then implemented by KHCCBIO newly trained staff.
WP7: Disseminating & Applying KHCCBIO bank & Capacity building. During the project period KHCC used several tools to disseminate the outcomes of the KHCCBIO project to guarantee its sustainability and arranged for KHCCBIO staff to train at EU-partners’ well established centers in this field for capacity building. KHCCBIO established a specific, unique and dynamic Website. It also wrote and distributed factsheets and prepared a Database of contacts, organisations, local/regional/national/pan-European authorities. KHCC also organized a final international conference titled “Conference on Cancer Biobanking: Establishing the First Cancer Biobank in Jordan,” which was sponsored by the FP7-EU program and considered as an initiative of KHCC with ESBB and WHO support. The conference was held under the patronage of HRH Princess Ghida Talal at the Le Meridian Hotel, Amman, Jordan on the 10th and 11th of April, 2014 to announce the inauguration of KHCCBIO. Several scientific papers related to the establishment of KHCCBIO were written and published in peer reviewed journals.
In brief, KHCCBIO bank approach is based on knowledge transfer between organizations and individuals from Europe and Jordan, in existing technological innovation and internationally recognized quality standards. Training courses on consent for tissue banking, procurement, processing and preservation will be performed by Trinity College Dublin (TCD), a college specialized in the management of thoracic malignancies. Training in ISO quality management, data privacy standards, equipment and systems infrastructure qualification, tissue storage and distribution standards will be executed by Biostόr Ireland, a fully accredited and EU-licensed tissue establishment.
Partners
1. The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin (TCD), Ireland
2. Accelopment AG, Switzerland
3. Biostόr Ireland Ltd, Ireland
Project Results:
Summary of the main scientific and technical foregrounds divided by work package.
WP2: Implementing Quality Measures
Main S&T results/foregrounds
KHCCBIO Quality Policy Manual finalised and approved by KHCCBIO chief quality officer.
192 documents required to meet ISO certification requirements were adapted/written by KHCCBIO, revised and approved by KHCCBIO chief quality officer (66 written by KHCC, 33 adapted from TCD and 93 adapted from Biostór).
192 required SOPs and Forms transferred into KHCCBIO templates were written, revised and approved by KHCCBIO chief quality officer.
KHCCBIO Validation Master Plan was finalised and approved by KHCCBIO chief quality officer.
Started implementing quality measures based on the ISO quality management system and the quality manual
Started implementing the validation system on all systems at KHCCBIO
All KHCCBIO technicians were trained by Dr. Lina Souan-KHCCBIO chief quality officer on performing validation for all systems at KHCCBIO such as freezers, refrigerators timers, thermometers, spectrophotometers, etc. as well as get them acquainted with KHCCBIO-ISO-QMS.
SOPs and forms created and written by KHCC alone in order to fulfill ISO standards required for this work package during the second periodic reporting phase were as follows.
Serial # DOCUMENT # Document Title
1 FRMLAB.KBB. 4.2.3-06 REPORT FORM
2 FRMLAB.KBB. 4.2.3-07 BMS MONTHLY ALARMS REPORT FORM
WP3: Supporting Policy Development
Main S&T results/foregrounds
- KHCC established a task-force to work on developing Policies on ethics, data privacy, sample ownership and KHCCBIO bylaws.
- KHCC developed and approved Consenting policy and forms
- KHCC developed and approved Privacy and confidentiality policy.
- KHCC assigned the KHCC-IRB to be the REC for the tissue bank
- KHCC finalized KHCCBIO biobanking bylaws and approved by KHCCBIO director and the chief quality officer fulfilling task 3.3.
- Finalized and approved developing access to biobank and MTA policies by KHCCBIO chief quality officer fulfilling task 3.3.
- SOPs and forms received from Biostór & TCD and were revised, adapted to KHCCBIO and approved by KHCCBIO chief quality officer and approved were as follows.
Serial # DOCUMENT # Document Title
1 IPPLAB.KBB. 4.2.3-03 Good Document Management
2 IPPLAB.KBB. 4.2.3-04 Signature Register
3 IPPLAB.KBB. 4.2.3-05 Control Of Documents In The KHCCBIO Library
4 IPPLAB.KBB. 4.2.4-01 Record Control
5 IPPLAB.KBB. 4.2.4-03 Data Privacy and Confidentiality Policy
6 IPPLAB.KBB. 7.2.1-04 Non Disclosure Agreement (NDA)
7 FRMLAB.KBB. 7.2.1-04 Non Disclosure Agreement Form(NDA)
8 IPPLAB.KBB. 7.2.1-05 Informed Consent Process
9 FRMLAB.KBB. 7.2.1-05 Patient Consent Form
10 FRMLAB.KBB. 7.2.1-06 Patient Information Sheet
11 FRMLAB.KBB. 7.2.1-07 Medical History Form
WP4: Harmonising Sampling
Main S&T results/foregrounds
- SOPs for Preservation and Disposal of Tissues & Samples were written and approved by KHCCBIO chief quality officer.
- SOPs for Thoracic tissue & associated blood sample procurement, processing and preservation were revised and adapted to KHCCBIO, reviewed and revised by KHCCBIO chief quality officer and deputy director, approved by KHCCBIO director then implemented by KHCCBIO staff.
- SOPs and forms received from Biostór & TCD and were revised and adapted to KHCCBIO, reviewed and revised by KHCCBIO chief quality officer and deputy director, approved by KHCCBIO director then implemented by KHCCBIO staff.
Serial # DOCUMENT # Document Title
1 FRMLAB.KBB. 6 3 2-13 Refrigerated Centrifuge Maintenance Log
2 FRMLAB.KBB. 6.3.2-16 Maintenance Of The Bright Light Inverted Microscope
3 IPPLAB.KBB. 6.3.2-21 Operation, Maintenance And Calibration Of The Multichannel Micropipettes
4 IPPLAB.KBB. 6.3.2-23 Operation Of The Nanodrop Spectrophotometer
5 IPPLAB.KBB. 6.3.2-25 Operation, Maintenance And Calibration Of The Analytical Balance
6 IPPLAB.KBB. 6.3.2-30 Operation & Maintenance Of The Refrigerated Centrifuge
7 IPPLAB.KBB. 6.3.2-33 Operation Of The Bright Light Inverted Microscope
8 IPPLAB.KBB. 6.3.2-35 Operation And Maintenance Of The 37ºC Incubator
9 IPPLAB.KBB. 7.5.1-06 Lung Tissue Collection
10 IPPLAB.KBB. 7.5.5-01 Assessment Of The Research Participant
11 IPPLAB.KBB. 7.5.1-12 SOP ALLPREP
12 IPPLAB.KBB. 7.5.5-02 Safety Guidelines For Blood Collection
13 IPPLAB.KBB. 7.5.5-03 Safety Guidelines For Disposal Of Sharps
14 IPPLAB.KBB. 7.5.5-04 Safety Guidelines For Handling Of Biological Materials
15 IPPLAB.KBB. 7.5.5-06 Safety Guidelines For Handling Of Chemical Hazards
16 IPPLAB.KBB. 7.5.5-07 Safety Guidelines For Handling Dry Ice
17 IPPLAB.KBB. 7.5.5-08 Blood Collection -Venepuncture
18 FRMLAB.KBB. 7.5.5-07 Serum And Plasma Preparation Record
19 IPPLAB.KBB. 7.5.5-10 DNA Extraction From Whole Blood
20 FRMLAB.KBB. 7.5.5-10 DNA Extraction Record
21 IPPLAB.KBB. 7.5.5-11 RNA Extraction From Whole Blood
22 IPPLAB.KBB. 7.5.5-12 Processing of Fresh Tissue
23 IPPLAB.KBB. 7.5.5-13 Protein Quantification Using The BCA Array
24 IPPLAB.KBB. 7.5.5-15 Isolation Of MNCs From Peripheral Blood
25 IPPLAB.KBB. 7.5.5-16 DNA Extraction From MNCs
26 IPPLAB.KBB. 7.5.5-17 RNA Extraction From MNCs
27 IPPLAB.KBB. 7.5.5-18 Processing Of Lung Tissue Samples FFPE
28 IPPLAB.KBB. 7.5.5-19 Processing Of Lung Tissue Samples Frozen Sections
29 IPPLAB.KBB. 7.5.5-20 DNA Extraction From Frozen Tissue
30 IPPLAB.KBB. 7.5.5-21 DNA Extraction From Paraffin Embedded Tissue
31 IPPLAB.KBB. 7.5.5-22 DNA Extraction From Formalin Fixed Tissue
32 IPPLAB.KBB. 7.5.5-23 RNA Extraction From Tissue
33 IPPLAB.KBB. 7.5.5-24 Protein Extraction From Tissue
SOPs and forms created and written by KHCC alone in order to fulfill ISO standards required for this work package during the second periodic reporting phase were as follows.
Serial # DOCUMENT # Document Title
1 FRMLAB.KBB. 4.2.3-08 BMS MONTHLY REPORT FORM
2 FRMLAB.KBB. 6.2.2-07 BIOBANK TRAINING EVALUATION FORM
3 FRMLAB.KBB. 6.2.2-08 KHCCBIO COMPETENCY FORM
4 DWGLAB.KBB. 7.5.3-01 LN2 FREEZER INVENTORY LAYOUT
5 DWGLAB.KBB. 7.5.3-02 FREEZER -80ºC INVENTORY LAYOUT
6 FRMLAB.KBB. 7.5.1-02 SAMPLE COLLECTION LOG
7 FRMLAB.KBB. 7.5.5-13 REAGENT INVENTORY
8 FRMLAB.KBB. 7.5.5-12 PROTEIN EXTRACTION Form
9 FRMLAB.KBB. 5.6-02 MINUTES OF MEETING
WP5: Assisting Verification
Main S&T results/foregrounds
- KHCC issued and approved all validation plan related documents
- KHCC used IQ and OQ templates for to validate all new equipment
- Wrote the final Validation Report.
- KHCCBIO Equipment List was written and finalized and up-to-date.
- Obtained onsite training on IQ, OQ and report writing from Biostór during the second consortium meeting visit to Amman May 26-29, 2013.
- SOPs and forms created and written by KHCC alone in order to fulfill ISO standards required for this work package during the second periodic reporting phase were as follows.
Serial # DOCUMENT # Document Title
1 FRMLAB.KBB. 6.3.2-01 LN2 Tank Daily Check
2 FRMLAB.KBB. 6.3.2-04 Back-Up Generator Daily, Weekly & Monthly Check
3 FRMLAB.KBB. 6.3.2-05 Temperature Alarm Test Log Sheet
4 FRMLAB.KBB. 6.3.2-07 Vortex Preventive Maintenance
5 FRMLAB.KBB. 6.3.2-08 Generator Service Form
6 FRMLAB.KBB. 6.3.2-17 Biological Safety Cabinet Preventive Maintenance
7 FRMLAB.KBB. 6.3.2-18 Weekly Homogenizer Cleaning Checklist
8 FRMLAB.KBB. 6.3.2-19 Oxygen Sensor Preventive Maintenance
9 FRMLAB.KBB. 6.3.2-20 Grossing Station Maintenance Log
10 FRMLAB.KBB. 6.3.2-21 Good Pipetting Instructions
11 FRMLAB.KBB. 6.3.2-22 Pipette Cleaning Instructions
12 FRMLAB.KBB. 6.3.2-23 Pipettes (Gilson And Eppendorf) Troubleshooting
13 FRMLAB.KBB. 6.3.2-24 Gilson ISO Specifications
14 FRMLAB.KBB. 6.3.2-25 Eppendorf Pipettes Maximum Permissible Errors Lists
15 FRMLAB.KBB. 6.3.2-26 Cryoshipper IQ-OQ Form
16 FRMLAB.KBB. 6.3.2-27 Nanodrop Preventive Maintenance
17 FRMLAB.KBB. 6.3.2-28 Centrifuge Preventive Maintenance
18 FRMLAB.KBB. 6.3.2-29 BMS Daily Check
19 FRMLAB.KBB. 6.3.2-30 Nanodrop Cleaning Log
20 FRMLAB.KBB. 6.3.2-31 Nanodrop Calibration And Conditioning
21 FRMLAB.KBB. 6.3.2-32 Vortex Daily Check
22 FRMLAB.KBB. 6.3.2-33 Analytical Balance Preventive Maintenance
23 FRMLAB.KBB. 6.3.2-34 Inverted Microscope Daily Monthly Annual Maintenance
24 FRMLAB.KBB. 6.3.2-35 Cryostat Preventive Maintenance
25 FRMLAB.KBB. 6.3.2-36 (-80) Freezer IQ-OQ Form
26 FRMLAB.KBB. 6.3.2-37 Autoclave Preventive Maintenance Form
27 FRMLAB.KBB. 6.3.2-38 Incubator Daily Monthly Check
28 FRMLAB.KBB. 6.3.2-39 Incubator Preventive Maintenance
29 FRMLAB.KBB. 6.3.2-40 LN2 Tank Logbook
30 FRMLAB.KBB. 6.3.2-41 Daily Room Temperature And Humidity Recording Form
31 FRMLAB.KBB. 6.3.2-42 CO2 Cylinder Logbook
32 FRMLAB.KBB. 6.3.2-43 Thermomixer Daily Check
33 FRMLAB.KBB. 6.3.2-44 Refrigerator Daily Check
34 FRMLAB.KBB. 6.3.2-45 Biological Safety Cabinet Daily, Monthly Check
35 FRMLAB.KBB. 6.3.2-46 Analytical Balance Daily Check
36 FRMLAB.KBB. 6.3.2-47 Autoclave Daily, Weekly Check
37 FRMLAB.KBB. 6.3.2-48 Thermomixer Preventive Maintenance
38 FRMLAB.KBB. 6.3.2-49 Laminar Flow Hood Daily, Monthly, Annual Maintenance
WP6: Banking & Collaborating
Main S&T results/foregrounds
- Along with our partners at TCD, KHCC conducted a cross-validation of RNA and DNA yields and quality/integrity from matched normal and lung tumor tissues between TCD (Ireland) and KHCC (Jordan) following transportation from Ireland to Jordan using a cryoshipper which was validated to be used for these procedures.
- Biostór Ireland, Co Wexford, Ireland hosted a wrap up meeting for Dr Maher Sughayer on April 30 –May 2, 2014
- The validation protocol and results were shared with TCD and a joined authorship paper publication in this regard was written and submitted to Biopreservation and Biobanking and published in February 2014, 12(1): 3-12.
Martin Barr*, Lina Souan∗, Peadar MacGabhann, Jeanette Müller, Maxim Al Ashhab, Mohammed Jasser, Khetam Hamza, Sallam Al Hassoon, Uwe Kuhn, Daniela Infante, Denise Lawlor, Kathy Gately, Eyad Amireh, Kenneth O’Byrne, Maher A. Sughayer. The Establishment of an ISO compliant Cancer Biobank for Jordan and its neighboring countries through knowledge transfer & training. Biopreservation and Biobanking.
* First two authors have equal contribution.
- SOPs and forms written/revised, and adapted to KHCCBIO and approved by KHCCBIO chief quality officer during the second periodic phase were as follows.
Serial # DOCUMENT # Document Title
1 IPPLAB.KBB.7.5.1-01 Incoming Inspection of Samples & Containers
2 FRMLAB.KBB. 7.5.1-01 Sample Collection Request
3 FRMLAB.KBB. 7.5.1-02 Sample Collection Log
4 IPPLAB.KBB.7.5.1-02 Transportation of Biological Samples
5 IPPLAB.KBB.7.5.1-04 Sample Retrieval for Distribution
6 FRMLAB.KBB. 7.5.1-04 Incoming Materials Log
7 FRMLAB.KBB. 7.5.1-05 Sample & Container Inspection report
8 FRMLAB.KBB. 7.5.1-06 Sample Shipment Log
9 FRMLAB.KBB. 7.5.1-07 Waybill Number List
10 FRMLAB.KBB. 7.5.1-08 Waybill
11 FRMLAB.KBB. 7.5.1-10 Transfer Checklist for Diagnostic/Clinical Specimens
12 FRMLAB.KBB.6.3.2-02 Cryoshipper Checklist
SOPs and forms created and written by KHCC alone in order to fulfill ISO standards required for this work package during the second periodic reporting phase were as follows.
Serial # DOCUMENT # Document Title
1 IPPLAB.KBB. 6.3.2-07 Operation & Maintenance Of The Generator
2 IPPLAB.KBB. 6.3.2-10 Operation & Maintenance Of The Laminar Flow Hood
3 IPPLAB.KBB. 6.3.2-18 Operation Of The Biobank Monitoring System (BMS)
4 IPPLAB.KBB. 6.3.2-26 Operation Of The KHCCBIO Barcode System
5 IPPLAB.KBB. 6.3.2-32 Operation & Maintenance Of The Cryostat
6 IPPLAB.KBB. 6.3.2-34 Operation, Maintenance, Qualification And Calibration Of The Autoclave
7 IPPLAB.KBB. 6.4.1-02 Personal Protective Equipment
8 IPPLAB.KBB. 7.5.3-01 Sample Identification And Traceability
9 IPPLAB.KBB. 7.5.5-12 Processing Of Fresh Tissue
10 DWGLAB.KBB. 8.2.3-01 Infrastructure
11 FRMLAB.KBB. 7.5.5-13 Reagent Inventory
12 FRMLAB.KBB. 8.2.3-06 IP Address Index
13 IPPLAB.KBB.5.5.1-08 Health And Safety For Khccbio Personnel
14 FRMLAB.KBB. 6.3-03 Equipment Annual Calendar
WP7: Disseminating & Applying KHCCBIO bank & Capacity building for KHCCBIO sustainability
Main S&T results/foregrounds
Dissemination and exploitation:
- Press release and numerous newspaper, magazine, scientific journals, radio and TV interviews held by the consortium members to explain the concepts of biobanking and the mission of KHCCBIO to the public. These activities are listed in Appendix I & II below.
- Website running as of Sept. 2012 (SFTP for consortium members in March, 2012)
- Flyers distributed in international conferences
- Promotion of KHCCBIO project at the EU-Jordan networking conferences
- Membership in the ESBB (KHCCBIO appears on their website)
- Participation at the ESBB meetings (listed under conferences section below).
- Project Public events.
- Staff training;
- One junior pathologist and two medical technologists travelled to Ireland and trained for 2 weeks at TCD/St. James and at Biostór on sample procurement, processing, preservation, storage, quality systems, safety, validation, consenting.
- KHCC Staff training on FP7 project and financial management
- KHCCBIO document controller had training at Biostór Ireland in Change Control, Document Control, and Record Control.
- TCD and Biostór Ireland provided onsite training at King Hussein Cancer Centre, Amman, Jordan to KHCCBIO Staff in Biobank operations, equipment validation, quality systems, document control
- KHCC was responsible for project monitoring and evaluation as part of an ongoing quality control work scope; hence, it applied the Deming Cycle (PDCA cycle) for this purpose and assigned quality indicators as well. Dissemination and exploitation process is one of these monitored and controlled processes, so as to assess the impact of the project on targeted stakeholders in order to determine the future sustainability, and to assess the degree to which the dissemination and exploitation plan is achieving its goals.
- KHCCBIO established a network of regional, Middleastern, European and international stakeholders
- KHCCBIO also established Networking with research centers in Europe and the rest of the world
- KHCCBIO established networking with pharmaceutical companies
Co-operation with other projects/programmes and conference presentations
A. Press Releases
Please refer to Appendix I
B. Conferences
Please refer to Appendix II
C. Publications
a. Posters, Abstracts & Flyers
1. Mohammad Mustafa, B.Sc. Lina Souan, M.Sc. Ph.D. Khetam Hamza, M.Sc. Maxim Al-Ashhab, MD., and Maher Sughayer, MD. KHCCBIO- Supporting the establishment of a cancer biobank for Jordan and its neighboring countries through knowledge transfer and training. Poster 2012
2. Lina Souan, M.Sc. Ph.D. Mohammad Mustafa, B.Sc. Khetam Hamza, M.Sc. Sallam Alhassoon, M.Sc. Maxim Al-Ashhab, MD., and Maher Sughayer, MD. KHCCBIO- Supporting the establishment of a cancer biobank for Jordan and its neighboring countries through knowledge transfer and training. Poster 2013
3. Martin Barr, Lina Souan, Peadar MacGabhann, Jeanette Müller, Maxim Ashhab, Sallam Alhassoon, Uwe Kuhn, Daniela Infante, Mohammed Mustafa, Khetam Mahmoud, Kathy Gately, Denise Lawlor, Kenneth O’Byrne, Maher A. Sughayer. The Establishment of an ISO Compliant Cancer Biobank for Jordan and its Neighbouring Countries Through Knowledge Transfer & Training. Poster 2013:
4. Flyer 2012: KHCCBIO- Supporting the establishment of a cancer biobank for Jordan and its neighboring countries through knowledge transfer and training. Issue 01.
5. Flyer 2013: In collaboration with EU members through FP7 project, King Hussein Cancer Center is in the process of establishing the first ISO compliant Biobank in Jordan and the Region. Issue 02.
6. M Morente, P Riegman, D Smith, Y Lee, P Bartels, M Sughayer, K Siddiqui, M Neumaier, F Betsou, B Parodi. Joint Conference of the European, Middle Eastern & African Society for Biopreservation & Biobanking (ESBB) and the Spanish National Biobank Network Granada, Spain November 7–9, 2012; ( Published abstract in Biopreservation and Biobanking 01/2012; 10(5):A1-A66.)
b. Peer Reviewed Articles
7. Rita T. Lawlor, Patrick M. Sluss, Rupert Langer, Maher A. Sughayer, Michael A. Igbe, Khalid Siddiqui, Pasquale De Blasio, Bonginkosi Duma, Maimuna Mendy, Christian Chabannon, and Muntaser Ibrahim. European, Middle Eastern, and African Society for Biopreservation and Biobanking (ESBB). 2012 Conference Session on Biobanking in Emerging Countries. BIOPRESERVATION AND BIOBANKING Volume 11, Number 3, 2013 Mary Ann Liebert, Inc. DOI: 10.1089/bio.2013.001
8. Barr*, Lina Souan*, Peadar MacGabhann, Jeanette Müller, Maxim Al Ashhab, Mohammed Jasser, Khetam Hamza, Sallam Al Hassoon, Uwe Kuhn, Daniela Infante, Denise Lawlor, Kathy Gately, Eyad Amireh, Kenneth O’Byrne, Maher A. Sughayer. The Establishment of an ISO compliant Cancer Biobank for Jordan and its neighboring countries through knowledge transfer & training. Biopreservation and Biobanking. Biopreservation and Biobanking. February 2014, 12(1): 3-12.
* The first two authors have equal contribution.
D. Oral Presentations/Poster Presentations
1. November 7-10, 2012- ESBB annual meeting 2012 in Granada. ESBB and Spanish national biobank network joint conference. Oral presentation: Dr. Maher Sughayer, "The progressive challenges approaches at the bio banking in emerging countries".
2. October 22-23, 2012 - International Conference on Mediterranean Countries and EU Opportunities. Le Meridien Hotel, Amman. Jordan.
- Oral presentation: Dr. Maher Sughayer. Session 2: Synergies, Complementarities and Networking. KHCCBIO Era-wide project. Jordan.
- Poster presentation: KHCCBIO - Supporting the Establishment of a Cancer Biobank for Jordan and its Neighboring Countries Through Knowledge Transfer & Training. Mohammad Mustafa, B.Sc. Lina Souan, M.Sc. Ph.D. Khetam Hamza, M.Sc. Maxim Al-Ashhab, MD., and Maher Sughayer, MD.
3. March 23-26, 2013 - 3rd International Jordanian Medical Laboratories Conference. Landmark hotel. Amman, Jordan. Oral presentation: Dr. Maher Sughayer, "Tissue banking".
4. April 16, 2013 - Jordan Europe Wide Enhanced research Links in ICT (JEWEL) conference "Get ready for HORIZON 2020". Landmark hotel, Amman, Jordan. Poster presentation. KHCCBIO - Supporting the Establishment of a Cancer Biobank for Jordan and its Neighbouring Countries Through Knowledge Transfer & Training. Lina Souan, M.Sc. Ph.D. Mohammad Mustafa, B.Sc. , Khetam Hamza, M.Sc. Sallam Al Hassoon, M.Sc. Maxim Al-Ashhab, MD, PhD, and Maher Sughayer, MD.
5. April 19-27, 2013 - Arab Medical Association Against Cancer (AMAAC). The 13th Pan Arab Cancer Congress. Le Meridien Hotel, Amman, Jordan. Poster presentation. KHCCBIO - Supporting the Establishment of a Cancer Biobank for Jordan and its Neighbouring Countries Through Knowledge Transfer & Training. Lina Souan, M.Sc. Ph.D. Mohammad Mustafa, B.Sc. , Khetam Hamza, M.Sc. Sallam Al Hassoon, M.Sc. Maxim Al-Ashhab, MD, PhD, and Maher Sughayer, MD.
6. Maher A.Sughayer MD, FCAP “Biobanking in Jordan” Conference on Cancer Biobanking Establishing the first Cancer Biobank in Jordan Amman, April 2014
7. Lina Souan, M.Sc. Ph.D “Critical Ethical Issues in Emerging Biobanks” Conference on Cancer Biobanking Establishing the first Cancer Biobank in Jordan Amman, April 2014
E. Awards:
The Establishment of an ISO Compliant Cancer Biobank for Jordan and its Neighbouring Countries Through Knowledge Transfer & Training [13]
Martin Barr, Lina Souan, Peadar MacGabhann, Jeanette Müller, Maxim Ashhab, Sallam Alhassoon, Uwe Kuhn, Daniela Infante, Mohammed Mustafa, Khetam Mahmoud, Kathy Gately, Denise Lawlor, Kenneth O’Byrne, Maher A. Sughayer
Source: http://www.esbb.org/verona/posters.html
F. TV Dialogues during the second periodic reporting phase
Date Channel Interviewee
28th, April 2014 - Aljazeerah Interview with Dr. Maher Sughayer http://www.aljazeera.net/reportslibrary/pages/591e7d06-4b06-452e-addd-1ee4900ad0cd
April 9th, 2014 - Ro’ya TV Interview with Dr. Maher Sughayer http://youtu.be/Cn8Z98-dhn4
G. Website
KHCCBIO website
KHCCBIO website is running as of Sept. 2012. It displays the logo of FP7 and the common European flag along with links to the corresponding websites. It has components to learn about biobanking. It also displays the logos of all partners on the home page also with links to their corresponding websites. There is ongoing work to update the website regularly. A tool for website statistics is in place. Pages with details on the functions, dissemination and other activities are also provided. the website provided content management and ability to update contents for each partner so partners can upload their news directly to the website. A dynamic interactive view is done.
The website address is:
http://khccbio.khcc.jo
Appendix I : Press Releases
Nº Title Date
1 Establishing the first bank to store cancer tissue in the region 21/11/2011
2 KHCCBIO Supporting the Establishment of a Cancer Biobank for Jordan and 20/11/2011
3 King Hussein Cancer Center announces the launch of the project of establishing the first bank 20/11/2011
4 Establishment of the first BIO Bank (KHCCBIO) in Jordan 20/11/2011
5 The launch of the project to establish the first bank to store cancerous tissue in Jordan 20/11/2011
6 First among Arab countries . Bank of cancerous tissue in Jordan 21/11/2011
7 King Hussein Cancer Center announces the launch of the establishment of the first BIO Bank (KHCCBIO) 21/11/2011
8 The launch of a project to establish the first bank to store the cancerous tissue in Jordan 20/11/2011
9 Announce the establishment of the first bank to store cancerous tissue in Jordan 21/11/2011
10 Scientific breakthrough, the establishment of a tissue bank to store cancer tissue. By Ahmed Jamil S 22/11/2011
11 The launch of the project to establish the first bank to store cancerous tissue in Jordan 21/11/2011
12 The launch of the first bank to store cancerous tissue in Jordan and the region 21/11/2011
13 Establishing the first bank to store malignant tissue in Jordan 20/11/2011
14 European support worth 550 thousand Euros to establish the first bank to store the cancer tissue 21/11/2011
15 Announcing the establishment of the first bank to store cancer tissue in Jordan 20/11/2011
16 First among Arab countries. Establish the first Arab bank to cancerous tissue in Jordan 21/11/2011
17 First among Arab countries. A bank to store cancerous tissue in Jordan 20/11/2011
18 KHCCBIO supporting the establishment of a cancer biobank for Jordan and its neighboring countries through knowledge transfer and training 1/6/2013
19 First cancer biobank established in Jordan 10/4/2014
20 Launching of the first cancer Biobank in Jordan 11/4/2014
21 Announcing the inauguration of the first cancer Biobank in Jordan 11/4/2014
22 Launching of the first cancer Biobank in Jordan 11/4/2014
23 Launching of the first cancer Biobank in Jordan 11/4/2014
24 Launching of the first cancer Biobank 10/4/2014
25 the inauguration of the first cancer Biobank in the Kingdom 11/4/2014
26 Launching of the first cancer Biobank in Jordan 11/4/2014
27 the inauguration of the first cancer Biobank in Jordan sponsored by the European Union 11/4/2014
28 the inauguration of the first cancer Biobank in Jordan 10/4/2014
29 cancer Biobank in Jordan 10/4/2014
30 First cancer biobank established in Jordan 11/4/2014
31 First cancer biobank established in Jordan 10/4/2014
32 Opening of the first cancer biobank in Jordan 10/4/2014
33 Opening of the first cancer biobank in the Kingdom 11/4/2014
34 4. Conference on Biobanking: Establishing the first Cancer Biobank in Jordan 10/4/2014
Appendix II: Project Dissemination Activities
A. Conferences
1. Joint EC-EIB-CMI Training Workshop For Mediterranean Research Centers
Held from 2011-10-03 to 2011-10-06 at the Center for Mediterranean Integration, Marseille, France.
2. 10th Annual British Thoracic Oncology Group Conference 2012 – Ireland
The 10th conference of BTOG was held from 25th to 27th January 2012 in Dublin, distributed project fact sheet leaflets
3. 11th Annual British Thoracic Oncology Group Conference 2013 – Ireland.
The 11th conference of BTOG was held from 23rd to 25th January 2013 in Dublin, distributed project factsheet leaflets.
4. International Cooperation with Mediterranean Partner Countries in FP7. Euro-Mediterranean Conference on Research and Innovation 2012. Barcelona 2-3 April 2012: distributed project factsheet leaflets
5. The 3rd ERA-WIDE Project. The ERA-WIDE project-3rd Workshop of coordination held from the 9th to 13th of July 2012 in Brussels, distributed project factsheet leaflets
6. Presented a lecture on KHCCBIO at the ESBB & Spanish National Biobank Network Joint Conference, Grenada, Spain. November 7-9, 2012,
7. Presented a lecture on Laboratory Accreditation at a MIRA workshop “Biometry in medical laboratories” Rabat, Morocco, November, 19-20, 2012
8. BCNET INTERNATIONAL WORKING GROUP MEETING 25–26 SEPTEMBER 2013. International Agency for Research on Cancer, Lyon, France
The Low-and Middle-Income Countries Biobank and Cohort Network (BCNet) International Working Group meeting was held at the International Agency for Research on Cancer (IARC), Lyon, on 25 and 26 September 2013. The BCNet initiative arose from the realization that despite improvements in developed countries, population cohorts and biobanking facilities are either underdeveloped or non-existent in low- and middle-income countries (LMICs); thus, public health professionals and decision-makers lack the scientific evidence about cancer causes and control measures that is needed to set up targeted and cost-effective action plans within their health-science systems. In addition, many LMICs have yet to develop standard guidelines and protocols regulating the sharing and use of biological samples for research purposes.
The organizations represented in the Working Group included the Biobanking and Biomolecular Resources Research Infrastructure (BBMRI), the International Society for Biological and Environmental Repositories (ISBER), the European, Middle Eastern and African Society for Biopreservation and Biobanking (ESBB), the African Organisation for Research & Training in Cancer (AORTIC), the Latin American and Caribbean Biobank Network (REBLAC), the National Cancer Research Institute (NCRI), United Kingdom, the Population Project in Genomics and Society (P³G) and the Spanish National Cancer Research Centre (CNIO).
The meeting was attended by 23 participants representing 14 LMICs from all of the WHO regions (South-East Asia, Western Pacific, Africa, Europe, Middle East and Pan-America) and nine international organizations, as well as IARC staff members. During the two days, the participants discussed:
The feasibility of and need for an LMIC network, what facilities are available, and whether there are initiatives that may overlap with BCNet.
Specific aims and objectives, and short-term and long-term goals.
IARC’s role in the network and advice on future steps.
Possible sources of funding for individual and collective projects.
Steering Committee members
Dr. Maher A. Sughayer was selected and given specific terms of reference and he will submit his recommendations to IARC and NCI/CGH by May 2014.
Source: Report of the LMIC BCNet meeting
9. ESBB’S 2013 ANNUAL CONFERENCE (8-11 OCTOBER 2013). Palazzo Della Gran Guardia, Verona, Italy.
Took place in Verona, Italy from the 8th to the 11th October. ESBB collaborated with the Italian node of BBMRI which held its launch or “kick-off” meeting the day before the main conference. This was the third ESBB annual conference following on from conferences in Marseille (2011) and Granada (2012).
The conference theme was “Biobanking for the Future” and it offered a wide variety of content from across the Biobanking spectrum. Sessions included: Global Biobanking, Ancient DNA, Biobanking for Personalised Medicine, Biobanking for Conservation, Sustainability of Biobanks and the Financial Crisis, and Innovative Biobanking. Another very important new feature was the Research Biobank of the Year Competition which was held for the first time at the Verona conference.
KHCCBIO was awarded for a biobank poster.
Source: http://www.esbb.org/verona/
10. BCNET steering committee 9-12 February 2014. WHO- IARC-Lyon-France for FP7.
11. TCD and Biostór Meeting 30 April – 5 May 2014 – Ireland – Dublin
12. The 3rd Jordanian International Conference of Jordan Society for medical Laboratory sciences, Medical labs: promising horizons (March 23, 2013-March 25, 2013)
Participation of Dr. Maher Sughayer and Dr. Lina Souan at JSMLS conference presenting KHCCBIO.
Under the Patronage of Her royal highness princess Basma Bint Talal, the Jordan society for medical laboratory sciences had their 3rd Jordanian international conference of Jordan society for medical laboratory sciences “Medical labs promising horizons” In collaboration with the international federation of clinical chemistry and laboratory medicine and the arab federation of clinical biology , Landmark hotel- Amman march 23-25, 2013.
A presentation by Dr. Maher Sughayer named KHCCBIO- Supporting the Establishment of a cancer Biobank for Jordan and its Neighbouring countries through knowledge transfer & training was given, and flyers were distributed.
Source: http://www.alrai.com/article/575484.html
The 3rd Jordanian International Conference of Jordan Society for medical Laboratory sciences, Medical labs: promising horizons Scientific program and abstracts book.
13. The 8th Jordanian International Electrical and Electronics Engineering Conference, (JIEEEC 2013) 16 - 18 April 2013
JIEEEC 2013 is organized by the Jordan Engineers Association (JEA) in cooperation with the Institution of Engineering and Technology (IET) Jordan Section, the Institute of Electrical and Electronics Engineers (IEEE) Jordan section, and FP7 JEWEL.
JEWEL Workshop at Landmark hotel (April 16, 2013-April 18, 2013):
A workshop organized by the Jordan Europe-Wide Enhanced Research Links in ICT (JEWEL) project, under the FP7 INCO ERA-WIDE programme. The workshop was held in conjunction with the 8th Jordanian International Electrical and Electronics Engineering Conference (JIEEEC) 2013, under the patronage of the president of the Jordan University of Sand Technology. The presentations focused on developing links between Europe and countries in the Middle East and North Africa (MENA) and grant opportunities under the EU’s Horizon 2020 programme, starting in 2014, for collaborative projects involving Mediterranean countries. The EU project officer who follows KHCCBIO project, Tanya Dimitrova, gave a key talk describing the operation and priorities of the new Horizon 2020 programme.
KHCCBIO staff attended the workshop, distributed flyers and posted banners and presented the KHCCBIO poster. Dr. Maher A. Sughayer gave a lecture about Biobanking and the project with deliverables so far and upcoming activities and plans.
Source: JIEEEC-2013
http://oldwww.just.edu.jo/jewel/next_act.aspx
14. Arab Medical Association Against Cancer (AMAAC) Le Meridien (April 26th-27th, 2013)
In collaboration with JOS and EASO were holding The 13th Pan Arab Cancer Congress April 26th– 27th, 2013 Le Méridien Hotel Amman - Jordan Dr. Lina Souan, Dr. Maher A. Sughayer and Mohammad Jasser attended the conference, and presented the Project with the flyers and the Poster.
Source: http://amaac.org/04.htm
15. The Final International Conference Part of the Project Deliverables. Conference on Biobanking: Establishing the first Cancer Biobank in Jordan (10-11 APRIL, 2014), Le Meridian, Amman, Jordan.
King Hussein Cancer Center organized a conference titled “Conference on Cancer Biobanking: Establishing the First Cancer Biobank in Jordan,” which was sponsored by the FP7-EU program and considered as an initiative of KHCC with ESBB and WHO support. The conference was held under the patronage of HRH Princess Ghida Talal at the Le Meridian Hotel, Amman, Jordan on the 10th and 11th of April, 2014.
The conference featured plenary lectures delivered by renowned local, regional and international clinicians, researchers and biobankers. Invaluable knowledge was delivered, and new partnerships were established between biobanks all over the world. A scientific exhibition of pharmaceuticals, medical and clinical equipment/ items related to biobanking and other related products also took place to allow for discussion and exchange of information between relevant delegates and leading industrial companies.
International Speakers:
Prof. Jan-Eric Litton - Karolinska Institute, Sweden
Prof. Kurt Zatloukal - Institute of Pathology, Medical University of Graz, Graz
Prof. Pasquale De Blasio - Founding President of ESBB. Milan, Italy
Dr. Rita Lawlor - University of Verona, Verona, Italy
Dr. Marianne Henderson - National Cancer Institute, National Institutes of Health, USA
Dr. Maimuna Mendy - International Agency for Research on Cancer, Lyon, France
Dr. Manuel M. Morente - Spanish National Cancer Center, Madrid, Spain
Ms. Tanya Dimitrova - Policy Officer - EU; Brussels, Belgium
Mr. Ma’n H. Zawati - Centre of Genomics and Policy – McGill University, Canada
Regional and Local Speakers:
Prof. Mostafa Abolfotouh - King Saud Bin-Abdulaziz University for Health Sciences, Saudi Arabia
Dr. Rania M. Labib - Children's Cancer Hospital-Egypt
Dr. Sonia Abdelhak - Institute Pasteur de Tunis, Tunisia
Dr. Hadi Abderrahim - Qatar Biobank, Qatar
Dr. Ahmad Samir - Children's Cancer Hospital ,Egypt
Dr. Maher Sughayer – King Hussein Cancer Center
Dr. Lina Souan – King Hussein Cancer Center
Dr. Mamoun Ahram – Jordan University, Amman, Jordan
Topics
• Session 1: History and Current Status of Biobanking
• Session 2: Biobanking in the Middle East & Low-Income Countries
• Session 3: Role of Biobanking in Public Health & Personalized Medicine
• Session 4: Ethics in Biobanking
• Session 5: Sustainability of Biobanks
• Session 6: Networking and Globalization of Biobanks
Some of the conference’s lectures and Interviews:
http://www.youtube.com/watch?v=lpxIY-FZOSo
http://www.youtube.com/watch?v=fT08xP7qJBc
http://www.youtube.com/watch?v=7nlmsnxpD90
http://www.youtube.com/watch?v=pPkKWaVojac
http://www.youtube.com/watch?v=oa75R2RObNQ
http://www.youtube.com/watch?v=z03CGt_HyzE
http://www.youtube.com/watch?v=Zf3B4gF_cBA
http://www.youtube.com/watch?v=89nicZGOgb4
B. Summary of Radio and TV Dialogues
The following table is a summary of all Radio and TV dialogues that were conducted by Dr. Maher Sughayer and Dr. Lina Souan on behalf of KHCCBIO tissue bank.
Date Channel Interviewee
Sunday 20th, November 2011 - Press conference
- Jordan TV
- Roaya TV
- Normina TV
- Alarabeyya and MBC TV
- Al Jazeera TV
- Al Ekhbaryya TV
- Al Rai newspaper
- The Jordan Times
- Addustour
- Alarab Al yawm
- Radio Amen FM
- Petra agency
- Al ghad news Launching the Tissue Bank in Jordan/ Dr. Maher Sughayer
Sunday 20th, November 2011 - Radio Hawa Amman Interview with Dr. Maher Sughayer regarding the tissue bank
Sunday 20th, November 2011 - Radio Amen FM Interview with Dr. Lina Souan
Sunday 20th, November 2011 - Jordan TV
- Normina
- Roaya
- Jazeera Interviews with Dr. Maher Sughayer and Dr. Lina Souan
Sunday 27th, November 2011 - Al Horra TV Interview with Dr. Maher Sughayer
Wednesday 28th, April 2014 - Aljazeerah Interview with Dr. Maher Sughayer.
http://www.aljazeera.net/reportslibrary/pages/591e7d06-4b06-452e-addd-1ee4900ad0cd
April 9th, 2014 - Ro’ya TV Interview with Dr. Maher Sughayer http://youtu.be/Cn8Z98-dhn4
Potential Impact:
KHCCBIO is expected to have a major impact and contribute to medical advances by providing
high-quality human biospecimens and data to the cancer research communities world-wide.
KHCCBIO will contribute to RTD capacity building and management in Jordan and neighbouring countries, increase scientific excellence and efficacy of Jordanian research in biomedical sciences, and better integrate Jordanian science and medicine with its European neighbours resulting in enhanced participation of Jordanian organisation in future EU-Framework Programmes.
KHCCBIO will be the nucleus for the establishment of a national biorepository in the Hashemite
kingdom of Jordan which will be the first in the region. The KHCCBIO bank will increase the visibility of the King Hussein Cancer Centre within Jordan, the neighbouring countries and throughout the world, facilitating communication between centres of similar scientific interest. The KHCCBIO bank will disseminate scientific information as well as the results of research, and will result in networking opportunities for KHCC researchers with other research centres in EU Member States and Associated Countries.
The establishment of the KHCCBIO bank will encourage the next generation of researchers from
Jordan and the region to start collaborations with researchers from Europe at a much earlier stage in their career, which will enable them to place science within the context of development in the Middle East using the stored biospecimens in the KHCCBIO bank. In this respect, the KHCCBIO bank will provide better job opportunities and better access to research infrastructures for young scientists and avoid the current “brain drain” phenomena which is a central part of Jordanian career development. Furthermore, promoting the importance and benefits of such a biobank to the scientific and non-scientific community will advance research and establish personalised medicine as well as aid the development of new pharmacogenomic drugs. While the primary impact of the KHCCBIO bank is to ensure the delivery of improvements in the prevention, diagnosis and treatment of Thoracic cancer, the establishment of such a resource also represents a major investment in Jordan’s knowledge economy because it will facilitate cutting-edge academia/industry research and development. A vital effect of the biobank is to improve patient care; it is also important that patients as well as the public in general understand the purpose of the biobank and the role that patients and the public alike can play in making it a success.
KHCCBIO will collect material following the highest ethical and quality standards accompanied with extensive clinical information so that researchers global wide will be able to access this information via the online database that will be established in order to make use of these resources in their research. We further anticipate that KHCCBIO will make special tumour cell lines prepared from our ethnic background that covers the entire Middle East region and make them commercially available which will give pharmaceutical companies and researchers in Europe and the world opportunities to develop clinically sound hypotheses that will help identify new diagnostic and therapeutic targets.
KHCCBIO became partners with the Low-and Middle-Income Countries (LMIC) Biobank and Cohort Network (BCNet). BCNet provides a platform for collaboration between its partners, IARC and the international community, to support biobanking and cohort-building activities, and to develop sustainable biobanking research infrastructures to facilitate the collection of high
-quality biological samples for research, using best practice principles and guidelines.
4.1.5 The address of the project public website, if applicable as well as relevant contact details.
KHCCBIO website is running as of Sept. 2012. It displays the logo of FP7 and the common European flag along with links to the corresponding websites. It has components to learn about biobanking. It also displays the logos of all partners on the home page also with links to their corresponding websites. There is ongoing work to update the website regularly. A tool for website statistics is in place. Pages with details on the functions, dissemination and other activities are also provided. Work is on going for the content management and update so partners can upload their news directly to the website. A dynamic interactive view is done.
The website address is:
http://khccbio.khcc.jo
Contact details: Dr. Maher Sughayer, msughayer@khcc.jo
1- Home
Contains a welcome note to the website, introducing KHCCBIO objectives and role in KHCC.
Also links to Partners’ websites, EU and FP7, KHCCBIO news and activities, contact us and number of website visitors.
الصفحة الرئيسية تحتوي على معلومات عامة عن بنك الأنسجة و أخبار بنك الأنسجة و النشاطات و يوجد روابط للشركاء
في المشروع.
2- About us:
An overall overview of KHCCBIO Project, Staff and Partners.
معلومات عن بنك الأنسجة و المشروع, فريق العمل و شركاء المشروع و مهماتهم.
نبذة عنّا
انشاء اول بنك حيوي لحفظ الانسجة السرطانية في الاردن والبلدان المجاورة لها من خلال تبادل المعرفة والتدريب بدعم من الاتحاد الاوربي
ان التطور الكبير في العلوم الطبية الحيوية يزيد من اهمية تجميع ودراسة عينات الانسجة المستخرجة والفائضة عن حاجة التشخيص لمرضى السرطان , وذلك لتحديد الجينات الرئيسية والاحماض النووية والبروتينات المسببة للسرطان . ومن استخدام هذه المعلومات للكشف المبكر عن السرطان ووضع نظام علاج شخصي لعلاج السرطان .
ن مستقبل الطب المخصص يعتمد على قدرة الباحثين على المقارنة بين التركيب الجزيئي الموجود في مئات من العينات وهذا يتطلب تحديد الاختلافات التي لها قيمة تشخيصية وعلاجية فقط. الا انه وللأسف فان الغالبية العظمة من ملايين العينات الحيوية المجمعة والموجودة حاليا في جميع انحاء العالم ليست مناسبة لصنع هذا النوع من المقارنات المباشرة التي تطلبها ابحاث السرطان الحديثة .والسبب بسيط وهو عدم وجود بروتوكول موحد يحكم كيفية جمع عينات الانسجة وكيفية اعدادها وتخزينها في بنوك الانسجة . حيث ان خلل طفيف في مرحلة من تلك المراحل يمكن ان يؤدي الى نتائج غير صحيحة مما يؤدي الى استحالة التميز بين البصمات الجزيئية المرتبطة بالسرطان وغيرها . من هنا جاءت اهمية هذا المشروع .
ان مشروع بنك الانسجة هو الاول من نوعه في الاردن وسيقام بدعم جزئي من الاتحاد الاوروبي يبلغ قدره 550 الف يورو ومن المقرر ان يباشر بنك الانسجة عمله خلال العامين القادمين حيث سيتم التركيز حاليا على كتابة السياسات والاجراءات وتدريب الاطباء والتقنيين على تجميع وتخزين الانسجة حسب ارشادات نظام ارشادات الايزو.
.
3. Publications:
Contains KHCCBIO flyers and publications that can be downloaded by pressing the link, these flyers explains the project’s objectives and goals and activities of KHCCBIO so far.
تحتوي الصفحة على الكتيبات التي نشرها بنك الأنسجة و فيها شرح عن أهداف بنك الأنسجة و النشاطات التي قام بها الى الوقت الحالي.
KHCCBIO is planning to issue a newsletter on a regular basis; in order to display the project’s achievements to the targeted audience and all concerned and possible stakeholders. It will include many divisions due to the different work packages’ activities. In addition, it will highlight the occurrence of all events related to the area of biobanking and personalized medicine in and outside the project.
1. Partners:
A brief introduction of each partner; ACCEL, BiostÓr, Trinity College Dublin and KHCC.
Each thumbnail is linked to the partner’s website to read more about.
نبذة قصيرة عن شركاء المشروع أسيلوبمنت و بيوستور و كلية ترينيتي في دبلن و مركز الحسين للسرطان.
يوجد رابط عند كل شريك للموقع الالكتروني.
2. Gallery:
Photo Albums from different events; Conferences, Meetings, KHCCBIO Laboratory, Staff Training and the Project Conference Announcements.
يحتوي على صور ملتقطة من المؤتمرات و المحاضرات و مختبران بنك الأنسجة و الاجتماعات و التدريب و الاعلان عن مؤتمر افتتاح بنك الأنسجة.
3. Contact us:
You can submit any question or note from the contact us, contact information are available; location, telephone number, fax and email.
للتواصل مع بنك الأنسجة عنوان الموقع, رقم الهاتف و الفاكس و البريد الالكتروني أو من خلال الموقع الالكتروني متوفر من خلال هذه الصفحة.
List of Websites:
public website address
http://khccbio.khcc.jo
contact person
Dr. Maher Sughayer
Maher A. Sughayer MD, FCAP
Full Member and Chairman,
Pathology & Laboratory Medicine Dept.
King Hussein Cancer Center
P.O.Box 1269
Amman 11941
Jordan
Tel: +962-6-5300460 ext1551
Fax: +962-6-5300460 ext 1552
Mobile: +962-77-7491216
King Hussein Cancer (KHCC) is a non-governmental and not-for-profit, specialized cancer centre in the Middle East that treats both adult and pediatric cancer patients from Jordan and the neighboring countries. KHCC is acknowledged as a leader in cancer treatment in the Middle East and its mission and vision is to maintain its leading position in cancer therapy . Hence, it embarked on establishing the first ISO accredited cancer biobank (KHCCBIO) for the purpose of collecting, processing, storing and distribution of cancer biospecimens that can help in the clarifying the disease cause and its effective treatment.
Currently, there are no or very few biobanks in the Middle East. However, KHCC changed this situation by establishing an ISO-compliant biospecimen repository (KHCCBIO) which incorporated all current international guidelines and best-in class practices under an approved quality management system to procure, process and store biospecimens for the benefit of researchers in Jordan, its neighboring countries, European researchers and researchers throughout the rest of the world. KHCCBIO bank follows the highest ethical standards in collecting, processing, storing and distributing these high-quality, clinically annotated biospecimens by consenting patients prior to collecting these samples and protect patients' rights and confidentiality.
KHCCBIO project was a 30 month project which started on 15/11/2011. KHCCBIO grant agreement was signed on the 29th of February 2012 and the EU pre-financing was received on March 19, 2012. Nevertheless; work started by holding the Kickoff meeting in November 19, 2011, as originally scheduled.
In brief, KHCCBIO bank approach is based on knowledge transfer between organizations and individuals from Europe and Jordan, in existing technological innovation and internationally recognized quality standards. Training courses on consent for tissue banking, procurement, processing and preservation was conducted by Trinity College Dublin , a college specialized in the management of thoracic malignancies. Training in ISO quality management, equipment and systems infrastructure qualification, tissue storage and distribution standards was executed by Biostόr Ireland, a fully accredited and EU-licensed tissue establishment. Future aims of the KHCCBIO support action are to develop KHCC’s research infrastructure, increasing its scope and visibility and improve its competitiveness throughout the European and worldwide biomedical science arena. Establish a platform for future knowledge transfer and collaborative research. Develop and enhance partnerships between European and Middle Eastern organizations for future staff exchanges, seminars and conferences focused on cancer. Disseminating KHCCBIO progress and activities particularly with EU early lung cancer (EUELC) collaborators to ensure the greatest impact and build competency in order to facilitate the participation of KHCC in future EU-calls.
Project Context and Objectives:
The main overall objective for the entire project period was to develop a biobank at KHCC for the purpose of collecting, processing, storing and distributing high-quality, clinically annotated biospecimens from consented patients that is compliant with international standards.
Description of the work performed and the main results achieved during the project were as follows.
WP 1: Coordinating Support Activities & Managing Project. KHCC successfully managed the KHCCBIO project throughout the project and took over the entire management part.
KHCC supervised and managed the achievement of the contractual deliverables and the milestones according to defined deadlines and submitted all scientific/technical reports on time. KHCC guaranteed prompt responses and disseminated information provided by the European Commission to the partners and arranged for telecons and webinars. Monitored work plan and partners activities and followed up on deliverables and sent reminders about work plan and progress to partners. Managed communication among partners and prepared a presentation on the project status and compiled a cost statement for the Technical Review at a project review meeting that was held in Brussels. KHCC was also responsible for the overall financial management of the KHCCBIO project whereas all partners are solely responsible for their own budgets and KHCC distributed the EC contribution to all partners according to the payment scheme laid down in the CA.
WP 2: Implementing Quality Measures. An ISO Quality Management System was established for KHCCBIO to operate according to it. Validation and Training Plans were written by KHCCBIO staff; reviewed & revised by KHCCBIO chief quality officer and deputy director and approved by KHCCBIO director.
WP 3: Supporting Policy Development. During the project period patient consenting policies, and forms for Consenting were written and approved for Ethics Application for Biobanking. Policies on Data Privacy & Confidentiality and Material Transfer Agreements, MTA’s policies were written to define rules for access to the bio-resource, ownership of biological samples and to ensure the highest standards of ethics and governance. KHCCBIO-Biobanking Bylaws were also written and approved. KHCCBIO staff was trained on the consenting process.
WP 4: Harmonising Sampling. SOP’s for the Procurement, Processing, Preservation and Disposal of blood and human tissue samples, based on existing Biobanking SOP’s in use within the Thoracic Oncology Biobank at TCD, in conjunction with international standards were written by KHCCBIO staff; reviewed & revised by KHCCBIO chief quality officer and deputy director and approved by KHCCBIO director then implemented by KHCCBIO staff.
WP 5: Assisting Verification. Installation Qualification (IQ) and Operation Qualification (OQ) protocols and draft Report formats for the identified equipment and systems from their existing Biostór QMS were adapted by KHCCBIO written by KHCCBIO staff; reviewed & revised by KHCCBIO chief quality officer and deputy director and approved by KHCCBIO director then implemented by KHCCBIO newly trained staff.
WP 6: Banking & Collaborating. SOPs for Thoracic tissue & associated blood sample storage and distribution were adapted by KHCCBIO written by KHCCBIO staff; reviewed & revised by KHCCBIO chief quality officer and deputy director and approved by KHCCBIO director then implemented by KHCCBIO newly trained staff.
WP7: Disseminating & Applying KHCCBIO bank & Capacity building. During the project period KHCC used several tools to disseminate the outcomes of the KHCCBIO project to guarantee its sustainability and arranged for KHCCBIO staff to train at EU-partners’ well established centers in this field for capacity building. KHCCBIO established a specific, unique and dynamic Website. It also wrote and distributed factsheets and prepared a Database of contacts, organisations, local/regional/national/pan-European authorities. KHCC also organized a final international conference titled “Conference on Cancer Biobanking: Establishing the First Cancer Biobank in Jordan,” which was sponsored by the FP7-EU program and considered as an initiative of KHCC with ESBB and WHO support. The conference was held under the patronage of HRH Princess Ghida Talal at the Le Meridian Hotel, Amman, Jordan on the 10th and 11th of April, 2014 to announce the inauguration of KHCCBIO. Several scientific papers related to the establishment of KHCCBIO were written and published in peer reviewed journals.
In brief, KHCCBIO bank approach is based on knowledge transfer between organizations and individuals from Europe and Jordan, in existing technological innovation and internationally recognized quality standards. Training courses on consent for tissue banking, procurement, processing and preservation will be performed by Trinity College Dublin (TCD), a college specialized in the management of thoracic malignancies. Training in ISO quality management, data privacy standards, equipment and systems infrastructure qualification, tissue storage and distribution standards will be executed by Biostόr Ireland, a fully accredited and EU-licensed tissue establishment.
Partners
1. The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin (TCD), Ireland
2. Accelopment AG, Switzerland
3. Biostόr Ireland Ltd, Ireland
Project Results:
Summary of the main scientific and technical foregrounds divided by work package.
WP2: Implementing Quality Measures
Main S&T results/foregrounds
KHCCBIO Quality Policy Manual finalised and approved by KHCCBIO chief quality officer.
192 documents required to meet ISO certification requirements were adapted/written by KHCCBIO, revised and approved by KHCCBIO chief quality officer (66 written by KHCC, 33 adapted from TCD and 93 adapted from Biostór).
192 required SOPs and Forms transferred into KHCCBIO templates were written, revised and approved by KHCCBIO chief quality officer.
KHCCBIO Validation Master Plan was finalised and approved by KHCCBIO chief quality officer.
Started implementing quality measures based on the ISO quality management system and the quality manual
Started implementing the validation system on all systems at KHCCBIO
All KHCCBIO technicians were trained by Dr. Lina Souan-KHCCBIO chief quality officer on performing validation for all systems at KHCCBIO such as freezers, refrigerators timers, thermometers, spectrophotometers, etc. as well as get them acquainted with KHCCBIO-ISO-QMS.
SOPs and forms created and written by KHCC alone in order to fulfill ISO standards required for this work package during the second periodic reporting phase were as follows.
Serial # DOCUMENT # Document Title
1 FRMLAB.KBB. 4.2.3-06 REPORT FORM
2 FRMLAB.KBB. 4.2.3-07 BMS MONTHLY ALARMS REPORT FORM
WP3: Supporting Policy Development
Main S&T results/foregrounds
- KHCC established a task-force to work on developing Policies on ethics, data privacy, sample ownership and KHCCBIO bylaws.
- KHCC developed and approved Consenting policy and forms
- KHCC developed and approved Privacy and confidentiality policy.
- KHCC assigned the KHCC-IRB to be the REC for the tissue bank
- KHCC finalized KHCCBIO biobanking bylaws and approved by KHCCBIO director and the chief quality officer fulfilling task 3.3.
- Finalized and approved developing access to biobank and MTA policies by KHCCBIO chief quality officer fulfilling task 3.3.
- SOPs and forms received from Biostór & TCD and were revised, adapted to KHCCBIO and approved by KHCCBIO chief quality officer and approved were as follows.
Serial # DOCUMENT # Document Title
1 IPPLAB.KBB. 4.2.3-03 Good Document Management
2 IPPLAB.KBB. 4.2.3-04 Signature Register
3 IPPLAB.KBB. 4.2.3-05 Control Of Documents In The KHCCBIO Library
4 IPPLAB.KBB. 4.2.4-01 Record Control
5 IPPLAB.KBB. 4.2.4-03 Data Privacy and Confidentiality Policy
6 IPPLAB.KBB. 7.2.1-04 Non Disclosure Agreement (NDA)
7 FRMLAB.KBB. 7.2.1-04 Non Disclosure Agreement Form(NDA)
8 IPPLAB.KBB. 7.2.1-05 Informed Consent Process
9 FRMLAB.KBB. 7.2.1-05 Patient Consent Form
10 FRMLAB.KBB. 7.2.1-06 Patient Information Sheet
11 FRMLAB.KBB. 7.2.1-07 Medical History Form
WP4: Harmonising Sampling
Main S&T results/foregrounds
- SOPs for Preservation and Disposal of Tissues & Samples were written and approved by KHCCBIO chief quality officer.
- SOPs for Thoracic tissue & associated blood sample procurement, processing and preservation were revised and adapted to KHCCBIO, reviewed and revised by KHCCBIO chief quality officer and deputy director, approved by KHCCBIO director then implemented by KHCCBIO staff.
- SOPs and forms received from Biostór & TCD and were revised and adapted to KHCCBIO, reviewed and revised by KHCCBIO chief quality officer and deputy director, approved by KHCCBIO director then implemented by KHCCBIO staff.
Serial # DOCUMENT # Document Title
1 FRMLAB.KBB. 6 3 2-13 Refrigerated Centrifuge Maintenance Log
2 FRMLAB.KBB. 6.3.2-16 Maintenance Of The Bright Light Inverted Microscope
3 IPPLAB.KBB. 6.3.2-21 Operation, Maintenance And Calibration Of The Multichannel Micropipettes
4 IPPLAB.KBB. 6.3.2-23 Operation Of The Nanodrop Spectrophotometer
5 IPPLAB.KBB. 6.3.2-25 Operation, Maintenance And Calibration Of The Analytical Balance
6 IPPLAB.KBB. 6.3.2-30 Operation & Maintenance Of The Refrigerated Centrifuge
7 IPPLAB.KBB. 6.3.2-33 Operation Of The Bright Light Inverted Microscope
8 IPPLAB.KBB. 6.3.2-35 Operation And Maintenance Of The 37ºC Incubator
9 IPPLAB.KBB. 7.5.1-06 Lung Tissue Collection
10 IPPLAB.KBB. 7.5.5-01 Assessment Of The Research Participant
11 IPPLAB.KBB. 7.5.1-12 SOP ALLPREP
12 IPPLAB.KBB. 7.5.5-02 Safety Guidelines For Blood Collection
13 IPPLAB.KBB. 7.5.5-03 Safety Guidelines For Disposal Of Sharps
14 IPPLAB.KBB. 7.5.5-04 Safety Guidelines For Handling Of Biological Materials
15 IPPLAB.KBB. 7.5.5-06 Safety Guidelines For Handling Of Chemical Hazards
16 IPPLAB.KBB. 7.5.5-07 Safety Guidelines For Handling Dry Ice
17 IPPLAB.KBB. 7.5.5-08 Blood Collection -Venepuncture
18 FRMLAB.KBB. 7.5.5-07 Serum And Plasma Preparation Record
19 IPPLAB.KBB. 7.5.5-10 DNA Extraction From Whole Blood
20 FRMLAB.KBB. 7.5.5-10 DNA Extraction Record
21 IPPLAB.KBB. 7.5.5-11 RNA Extraction From Whole Blood
22 IPPLAB.KBB. 7.5.5-12 Processing of Fresh Tissue
23 IPPLAB.KBB. 7.5.5-13 Protein Quantification Using The BCA Array
24 IPPLAB.KBB. 7.5.5-15 Isolation Of MNCs From Peripheral Blood
25 IPPLAB.KBB. 7.5.5-16 DNA Extraction From MNCs
26 IPPLAB.KBB. 7.5.5-17 RNA Extraction From MNCs
27 IPPLAB.KBB. 7.5.5-18 Processing Of Lung Tissue Samples FFPE
28 IPPLAB.KBB. 7.5.5-19 Processing Of Lung Tissue Samples Frozen Sections
29 IPPLAB.KBB. 7.5.5-20 DNA Extraction From Frozen Tissue
30 IPPLAB.KBB. 7.5.5-21 DNA Extraction From Paraffin Embedded Tissue
31 IPPLAB.KBB. 7.5.5-22 DNA Extraction From Formalin Fixed Tissue
32 IPPLAB.KBB. 7.5.5-23 RNA Extraction From Tissue
33 IPPLAB.KBB. 7.5.5-24 Protein Extraction From Tissue
SOPs and forms created and written by KHCC alone in order to fulfill ISO standards required for this work package during the second periodic reporting phase were as follows.
Serial # DOCUMENT # Document Title
1 FRMLAB.KBB. 4.2.3-08 BMS MONTHLY REPORT FORM
2 FRMLAB.KBB. 6.2.2-07 BIOBANK TRAINING EVALUATION FORM
3 FRMLAB.KBB. 6.2.2-08 KHCCBIO COMPETENCY FORM
4 DWGLAB.KBB. 7.5.3-01 LN2 FREEZER INVENTORY LAYOUT
5 DWGLAB.KBB. 7.5.3-02 FREEZER -80ºC INVENTORY LAYOUT
6 FRMLAB.KBB. 7.5.1-02 SAMPLE COLLECTION LOG
7 FRMLAB.KBB. 7.5.5-13 REAGENT INVENTORY
8 FRMLAB.KBB. 7.5.5-12 PROTEIN EXTRACTION Form
9 FRMLAB.KBB. 5.6-02 MINUTES OF MEETING
WP5: Assisting Verification
Main S&T results/foregrounds
- KHCC issued and approved all validation plan related documents
- KHCC used IQ and OQ templates for to validate all new equipment
- Wrote the final Validation Report.
- KHCCBIO Equipment List was written and finalized and up-to-date.
- Obtained onsite training on IQ, OQ and report writing from Biostór during the second consortium meeting visit to Amman May 26-29, 2013.
- SOPs and forms created and written by KHCC alone in order to fulfill ISO standards required for this work package during the second periodic reporting phase were as follows.
Serial # DOCUMENT # Document Title
1 FRMLAB.KBB. 6.3.2-01 LN2 Tank Daily Check
2 FRMLAB.KBB. 6.3.2-04 Back-Up Generator Daily, Weekly & Monthly Check
3 FRMLAB.KBB. 6.3.2-05 Temperature Alarm Test Log Sheet
4 FRMLAB.KBB. 6.3.2-07 Vortex Preventive Maintenance
5 FRMLAB.KBB. 6.3.2-08 Generator Service Form
6 FRMLAB.KBB. 6.3.2-17 Biological Safety Cabinet Preventive Maintenance
7 FRMLAB.KBB. 6.3.2-18 Weekly Homogenizer Cleaning Checklist
8 FRMLAB.KBB. 6.3.2-19 Oxygen Sensor Preventive Maintenance
9 FRMLAB.KBB. 6.3.2-20 Grossing Station Maintenance Log
10 FRMLAB.KBB. 6.3.2-21 Good Pipetting Instructions
11 FRMLAB.KBB. 6.3.2-22 Pipette Cleaning Instructions
12 FRMLAB.KBB. 6.3.2-23 Pipettes (Gilson And Eppendorf) Troubleshooting
13 FRMLAB.KBB. 6.3.2-24 Gilson ISO Specifications
14 FRMLAB.KBB. 6.3.2-25 Eppendorf Pipettes Maximum Permissible Errors Lists
15 FRMLAB.KBB. 6.3.2-26 Cryoshipper IQ-OQ Form
16 FRMLAB.KBB. 6.3.2-27 Nanodrop Preventive Maintenance
17 FRMLAB.KBB. 6.3.2-28 Centrifuge Preventive Maintenance
18 FRMLAB.KBB. 6.3.2-29 BMS Daily Check
19 FRMLAB.KBB. 6.3.2-30 Nanodrop Cleaning Log
20 FRMLAB.KBB. 6.3.2-31 Nanodrop Calibration And Conditioning
21 FRMLAB.KBB. 6.3.2-32 Vortex Daily Check
22 FRMLAB.KBB. 6.3.2-33 Analytical Balance Preventive Maintenance
23 FRMLAB.KBB. 6.3.2-34 Inverted Microscope Daily Monthly Annual Maintenance
24 FRMLAB.KBB. 6.3.2-35 Cryostat Preventive Maintenance
25 FRMLAB.KBB. 6.3.2-36 (-80) Freezer IQ-OQ Form
26 FRMLAB.KBB. 6.3.2-37 Autoclave Preventive Maintenance Form
27 FRMLAB.KBB. 6.3.2-38 Incubator Daily Monthly Check
28 FRMLAB.KBB. 6.3.2-39 Incubator Preventive Maintenance
29 FRMLAB.KBB. 6.3.2-40 LN2 Tank Logbook
30 FRMLAB.KBB. 6.3.2-41 Daily Room Temperature And Humidity Recording Form
31 FRMLAB.KBB. 6.3.2-42 CO2 Cylinder Logbook
32 FRMLAB.KBB. 6.3.2-43 Thermomixer Daily Check
33 FRMLAB.KBB. 6.3.2-44 Refrigerator Daily Check
34 FRMLAB.KBB. 6.3.2-45 Biological Safety Cabinet Daily, Monthly Check
35 FRMLAB.KBB. 6.3.2-46 Analytical Balance Daily Check
36 FRMLAB.KBB. 6.3.2-47 Autoclave Daily, Weekly Check
37 FRMLAB.KBB. 6.3.2-48 Thermomixer Preventive Maintenance
38 FRMLAB.KBB. 6.3.2-49 Laminar Flow Hood Daily, Monthly, Annual Maintenance
WP6: Banking & Collaborating
Main S&T results/foregrounds
- Along with our partners at TCD, KHCC conducted a cross-validation of RNA and DNA yields and quality/integrity from matched normal and lung tumor tissues between TCD (Ireland) and KHCC (Jordan) following transportation from Ireland to Jordan using a cryoshipper which was validated to be used for these procedures.
- Biostór Ireland, Co Wexford, Ireland hosted a wrap up meeting for Dr Maher Sughayer on April 30 –May 2, 2014
- The validation protocol and results were shared with TCD and a joined authorship paper publication in this regard was written and submitted to Biopreservation and Biobanking and published in February 2014, 12(1): 3-12.
Martin Barr*, Lina Souan∗, Peadar MacGabhann, Jeanette Müller, Maxim Al Ashhab, Mohammed Jasser, Khetam Hamza, Sallam Al Hassoon, Uwe Kuhn, Daniela Infante, Denise Lawlor, Kathy Gately, Eyad Amireh, Kenneth O’Byrne, Maher A. Sughayer. The Establishment of an ISO compliant Cancer Biobank for Jordan and its neighboring countries through knowledge transfer & training. Biopreservation and Biobanking.
* First two authors have equal contribution.
- SOPs and forms written/revised, and adapted to KHCCBIO and approved by KHCCBIO chief quality officer during the second periodic phase were as follows.
Serial # DOCUMENT # Document Title
1 IPPLAB.KBB.7.5.1-01 Incoming Inspection of Samples & Containers
2 FRMLAB.KBB. 7.5.1-01 Sample Collection Request
3 FRMLAB.KBB. 7.5.1-02 Sample Collection Log
4 IPPLAB.KBB.7.5.1-02 Transportation of Biological Samples
5 IPPLAB.KBB.7.5.1-04 Sample Retrieval for Distribution
6 FRMLAB.KBB. 7.5.1-04 Incoming Materials Log
7 FRMLAB.KBB. 7.5.1-05 Sample & Container Inspection report
8 FRMLAB.KBB. 7.5.1-06 Sample Shipment Log
9 FRMLAB.KBB. 7.5.1-07 Waybill Number List
10 FRMLAB.KBB. 7.5.1-08 Waybill
11 FRMLAB.KBB. 7.5.1-10 Transfer Checklist for Diagnostic/Clinical Specimens
12 FRMLAB.KBB.6.3.2-02 Cryoshipper Checklist
SOPs and forms created and written by KHCC alone in order to fulfill ISO standards required for this work package during the second periodic reporting phase were as follows.
Serial # DOCUMENT # Document Title
1 IPPLAB.KBB. 6.3.2-07 Operation & Maintenance Of The Generator
2 IPPLAB.KBB. 6.3.2-10 Operation & Maintenance Of The Laminar Flow Hood
3 IPPLAB.KBB. 6.3.2-18 Operation Of The Biobank Monitoring System (BMS)
4 IPPLAB.KBB. 6.3.2-26 Operation Of The KHCCBIO Barcode System
5 IPPLAB.KBB. 6.3.2-32 Operation & Maintenance Of The Cryostat
6 IPPLAB.KBB. 6.3.2-34 Operation, Maintenance, Qualification And Calibration Of The Autoclave
7 IPPLAB.KBB. 6.4.1-02 Personal Protective Equipment
8 IPPLAB.KBB. 7.5.3-01 Sample Identification And Traceability
9 IPPLAB.KBB. 7.5.5-12 Processing Of Fresh Tissue
10 DWGLAB.KBB. 8.2.3-01 Infrastructure
11 FRMLAB.KBB. 7.5.5-13 Reagent Inventory
12 FRMLAB.KBB. 8.2.3-06 IP Address Index
13 IPPLAB.KBB.5.5.1-08 Health And Safety For Khccbio Personnel
14 FRMLAB.KBB. 6.3-03 Equipment Annual Calendar
WP7: Disseminating & Applying KHCCBIO bank & Capacity building for KHCCBIO sustainability
Main S&T results/foregrounds
Dissemination and exploitation:
- Press release and numerous newspaper, magazine, scientific journals, radio and TV interviews held by the consortium members to explain the concepts of biobanking and the mission of KHCCBIO to the public. These activities are listed in Appendix I & II below.
- Website running as of Sept. 2012 (SFTP for consortium members in March, 2012)
- Flyers distributed in international conferences
- Promotion of KHCCBIO project at the EU-Jordan networking conferences
- Membership in the ESBB (KHCCBIO appears on their website)
- Participation at the ESBB meetings (listed under conferences section below).
- Project Public events.
- Staff training;
- One junior pathologist and two medical technologists travelled to Ireland and trained for 2 weeks at TCD/St. James and at Biostór on sample procurement, processing, preservation, storage, quality systems, safety, validation, consenting.
- KHCC Staff training on FP7 project and financial management
- KHCCBIO document controller had training at Biostór Ireland in Change Control, Document Control, and Record Control.
- TCD and Biostór Ireland provided onsite training at King Hussein Cancer Centre, Amman, Jordan to KHCCBIO Staff in Biobank operations, equipment validation, quality systems, document control
- KHCC was responsible for project monitoring and evaluation as part of an ongoing quality control work scope; hence, it applied the Deming Cycle (PDCA cycle) for this purpose and assigned quality indicators as well. Dissemination and exploitation process is one of these monitored and controlled processes, so as to assess the impact of the project on targeted stakeholders in order to determine the future sustainability, and to assess the degree to which the dissemination and exploitation plan is achieving its goals.
- KHCCBIO established a network of regional, Middleastern, European and international stakeholders
- KHCCBIO also established Networking with research centers in Europe and the rest of the world
- KHCCBIO established networking with pharmaceutical companies
Co-operation with other projects/programmes and conference presentations
A. Press Releases
Please refer to Appendix I
B. Conferences
Please refer to Appendix II
C. Publications
a. Posters, Abstracts & Flyers
1. Mohammad Mustafa, B.Sc. Lina Souan, M.Sc. Ph.D. Khetam Hamza, M.Sc. Maxim Al-Ashhab, MD., and Maher Sughayer, MD. KHCCBIO- Supporting the establishment of a cancer biobank for Jordan and its neighboring countries through knowledge transfer and training. Poster 2012
2. Lina Souan, M.Sc. Ph.D. Mohammad Mustafa, B.Sc. Khetam Hamza, M.Sc. Sallam Alhassoon, M.Sc. Maxim Al-Ashhab, MD., and Maher Sughayer, MD. KHCCBIO- Supporting the establishment of a cancer biobank for Jordan and its neighboring countries through knowledge transfer and training. Poster 2013
3. Martin Barr, Lina Souan, Peadar MacGabhann, Jeanette Müller, Maxim Ashhab, Sallam Alhassoon, Uwe Kuhn, Daniela Infante, Mohammed Mustafa, Khetam Mahmoud, Kathy Gately, Denise Lawlor, Kenneth O’Byrne, Maher A. Sughayer. The Establishment of an ISO Compliant Cancer Biobank for Jordan and its Neighbouring Countries Through Knowledge Transfer & Training. Poster 2013:
4. Flyer 2012: KHCCBIO- Supporting the establishment of a cancer biobank for Jordan and its neighboring countries through knowledge transfer and training. Issue 01.
5. Flyer 2013: In collaboration with EU members through FP7 project, King Hussein Cancer Center is in the process of establishing the first ISO compliant Biobank in Jordan and the Region. Issue 02.
6. M Morente, P Riegman, D Smith, Y Lee, P Bartels, M Sughayer, K Siddiqui, M Neumaier, F Betsou, B Parodi. Joint Conference of the European, Middle Eastern & African Society for Biopreservation & Biobanking (ESBB) and the Spanish National Biobank Network Granada, Spain November 7–9, 2012; ( Published abstract in Biopreservation and Biobanking 01/2012; 10(5):A1-A66.)
b. Peer Reviewed Articles
7. Rita T. Lawlor, Patrick M. Sluss, Rupert Langer, Maher A. Sughayer, Michael A. Igbe, Khalid Siddiqui, Pasquale De Blasio, Bonginkosi Duma, Maimuna Mendy, Christian Chabannon, and Muntaser Ibrahim. European, Middle Eastern, and African Society for Biopreservation and Biobanking (ESBB). 2012 Conference Session on Biobanking in Emerging Countries. BIOPRESERVATION AND BIOBANKING Volume 11, Number 3, 2013 Mary Ann Liebert, Inc. DOI: 10.1089/bio.2013.001
8. Barr*, Lina Souan*, Peadar MacGabhann, Jeanette Müller, Maxim Al Ashhab, Mohammed Jasser, Khetam Hamza, Sallam Al Hassoon, Uwe Kuhn, Daniela Infante, Denise Lawlor, Kathy Gately, Eyad Amireh, Kenneth O’Byrne, Maher A. Sughayer. The Establishment of an ISO compliant Cancer Biobank for Jordan and its neighboring countries through knowledge transfer & training. Biopreservation and Biobanking. Biopreservation and Biobanking. February 2014, 12(1): 3-12.
* The first two authors have equal contribution.
D. Oral Presentations/Poster Presentations
1. November 7-10, 2012- ESBB annual meeting 2012 in Granada. ESBB and Spanish national biobank network joint conference. Oral presentation: Dr. Maher Sughayer, "The progressive challenges approaches at the bio banking in emerging countries".
2. October 22-23, 2012 - International Conference on Mediterranean Countries and EU Opportunities. Le Meridien Hotel, Amman. Jordan.
- Oral presentation: Dr. Maher Sughayer. Session 2: Synergies, Complementarities and Networking. KHCCBIO Era-wide project. Jordan.
- Poster presentation: KHCCBIO - Supporting the Establishment of a Cancer Biobank for Jordan and its Neighboring Countries Through Knowledge Transfer & Training. Mohammad Mustafa, B.Sc. Lina Souan, M.Sc. Ph.D. Khetam Hamza, M.Sc. Maxim Al-Ashhab, MD., and Maher Sughayer, MD.
3. March 23-26, 2013 - 3rd International Jordanian Medical Laboratories Conference. Landmark hotel. Amman, Jordan. Oral presentation: Dr. Maher Sughayer, "Tissue banking".
4. April 16, 2013 - Jordan Europe Wide Enhanced research Links in ICT (JEWEL) conference "Get ready for HORIZON 2020". Landmark hotel, Amman, Jordan. Poster presentation. KHCCBIO - Supporting the Establishment of a Cancer Biobank for Jordan and its Neighbouring Countries Through Knowledge Transfer & Training. Lina Souan, M.Sc. Ph.D. Mohammad Mustafa, B.Sc. , Khetam Hamza, M.Sc. Sallam Al Hassoon, M.Sc. Maxim Al-Ashhab, MD, PhD, and Maher Sughayer, MD.
5. April 19-27, 2013 - Arab Medical Association Against Cancer (AMAAC). The 13th Pan Arab Cancer Congress. Le Meridien Hotel, Amman, Jordan. Poster presentation. KHCCBIO - Supporting the Establishment of a Cancer Biobank for Jordan and its Neighbouring Countries Through Knowledge Transfer & Training. Lina Souan, M.Sc. Ph.D. Mohammad Mustafa, B.Sc. , Khetam Hamza, M.Sc. Sallam Al Hassoon, M.Sc. Maxim Al-Ashhab, MD, PhD, and Maher Sughayer, MD.
6. Maher A.Sughayer MD, FCAP “Biobanking in Jordan” Conference on Cancer Biobanking Establishing the first Cancer Biobank in Jordan Amman, April 2014
7. Lina Souan, M.Sc. Ph.D “Critical Ethical Issues in Emerging Biobanks” Conference on Cancer Biobanking Establishing the first Cancer Biobank in Jordan Amman, April 2014
E. Awards:
The Establishment of an ISO Compliant Cancer Biobank for Jordan and its Neighbouring Countries Through Knowledge Transfer & Training [13]
Martin Barr, Lina Souan, Peadar MacGabhann, Jeanette Müller, Maxim Ashhab, Sallam Alhassoon, Uwe Kuhn, Daniela Infante, Mohammed Mustafa, Khetam Mahmoud, Kathy Gately, Denise Lawlor, Kenneth O’Byrne, Maher A. Sughayer
Source: http://www.esbb.org/verona/posters.html
F. TV Dialogues during the second periodic reporting phase
Date Channel Interviewee
28th, April 2014 - Aljazeerah Interview with Dr. Maher Sughayer http://www.aljazeera.net/reportslibrary/pages/591e7d06-4b06-452e-addd-1ee4900ad0cd
April 9th, 2014 - Ro’ya TV Interview with Dr. Maher Sughayer http://youtu.be/Cn8Z98-dhn4
G. Website
KHCCBIO website
KHCCBIO website is running as of Sept. 2012. It displays the logo of FP7 and the common European flag along with links to the corresponding websites. It has components to learn about biobanking. It also displays the logos of all partners on the home page also with links to their corresponding websites. There is ongoing work to update the website regularly. A tool for website statistics is in place. Pages with details on the functions, dissemination and other activities are also provided. the website provided content management and ability to update contents for each partner so partners can upload their news directly to the website. A dynamic interactive view is done.
The website address is:
http://khccbio.khcc.jo
Appendix I : Press Releases
Nº Title Date
1 Establishing the first bank to store cancer tissue in the region 21/11/2011
2 KHCCBIO Supporting the Establishment of a Cancer Biobank for Jordan and 20/11/2011
3 King Hussein Cancer Center announces the launch of the project of establishing the first bank 20/11/2011
4 Establishment of the first BIO Bank (KHCCBIO) in Jordan 20/11/2011
5 The launch of the project to establish the first bank to store cancerous tissue in Jordan 20/11/2011
6 First among Arab countries . Bank of cancerous tissue in Jordan 21/11/2011
7 King Hussein Cancer Center announces the launch of the establishment of the first BIO Bank (KHCCBIO) 21/11/2011
8 The launch of a project to establish the first bank to store the cancerous tissue in Jordan 20/11/2011
9 Announce the establishment of the first bank to store cancerous tissue in Jordan 21/11/2011
10 Scientific breakthrough, the establishment of a tissue bank to store cancer tissue. By Ahmed Jamil S 22/11/2011
11 The launch of the project to establish the first bank to store cancerous tissue in Jordan 21/11/2011
12 The launch of the first bank to store cancerous tissue in Jordan and the region 21/11/2011
13 Establishing the first bank to store malignant tissue in Jordan 20/11/2011
14 European support worth 550 thousand Euros to establish the first bank to store the cancer tissue 21/11/2011
15 Announcing the establishment of the first bank to store cancer tissue in Jordan 20/11/2011
16 First among Arab countries. Establish the first Arab bank to cancerous tissue in Jordan 21/11/2011
17 First among Arab countries. A bank to store cancerous tissue in Jordan 20/11/2011
18 KHCCBIO supporting the establishment of a cancer biobank for Jordan and its neighboring countries through knowledge transfer and training 1/6/2013
19 First cancer biobank established in Jordan 10/4/2014
20 Launching of the first cancer Biobank in Jordan 11/4/2014
21 Announcing the inauguration of the first cancer Biobank in Jordan 11/4/2014
22 Launching of the first cancer Biobank in Jordan 11/4/2014
23 Launching of the first cancer Biobank in Jordan 11/4/2014
24 Launching of the first cancer Biobank 10/4/2014
25 the inauguration of the first cancer Biobank in the Kingdom 11/4/2014
26 Launching of the first cancer Biobank in Jordan 11/4/2014
27 the inauguration of the first cancer Biobank in Jordan sponsored by the European Union 11/4/2014
28 the inauguration of the first cancer Biobank in Jordan 10/4/2014
29 cancer Biobank in Jordan 10/4/2014
30 First cancer biobank established in Jordan 11/4/2014
31 First cancer biobank established in Jordan 10/4/2014
32 Opening of the first cancer biobank in Jordan 10/4/2014
33 Opening of the first cancer biobank in the Kingdom 11/4/2014
34 4. Conference on Biobanking: Establishing the first Cancer Biobank in Jordan 10/4/2014
Appendix II: Project Dissemination Activities
A. Conferences
1. Joint EC-EIB-CMI Training Workshop For Mediterranean Research Centers
Held from 2011-10-03 to 2011-10-06 at the Center for Mediterranean Integration, Marseille, France.
2. 10th Annual British Thoracic Oncology Group Conference 2012 – Ireland
The 10th conference of BTOG was held from 25th to 27th January 2012 in Dublin, distributed project fact sheet leaflets
3. 11th Annual British Thoracic Oncology Group Conference 2013 – Ireland.
The 11th conference of BTOG was held from 23rd to 25th January 2013 in Dublin, distributed project factsheet leaflets.
4. International Cooperation with Mediterranean Partner Countries in FP7. Euro-Mediterranean Conference on Research and Innovation 2012. Barcelona 2-3 April 2012: distributed project factsheet leaflets
5. The 3rd ERA-WIDE Project. The ERA-WIDE project-3rd Workshop of coordination held from the 9th to 13th of July 2012 in Brussels, distributed project factsheet leaflets
6. Presented a lecture on KHCCBIO at the ESBB & Spanish National Biobank Network Joint Conference, Grenada, Spain. November 7-9, 2012,
7. Presented a lecture on Laboratory Accreditation at a MIRA workshop “Biometry in medical laboratories” Rabat, Morocco, November, 19-20, 2012
8. BCNET INTERNATIONAL WORKING GROUP MEETING 25–26 SEPTEMBER 2013. International Agency for Research on Cancer, Lyon, France
The Low-and Middle-Income Countries Biobank and Cohort Network (BCNet) International Working Group meeting was held at the International Agency for Research on Cancer (IARC), Lyon, on 25 and 26 September 2013. The BCNet initiative arose from the realization that despite improvements in developed countries, population cohorts and biobanking facilities are either underdeveloped or non-existent in low- and middle-income countries (LMICs); thus, public health professionals and decision-makers lack the scientific evidence about cancer causes and control measures that is needed to set up targeted and cost-effective action plans within their health-science systems. In addition, many LMICs have yet to develop standard guidelines and protocols regulating the sharing and use of biological samples for research purposes.
The organizations represented in the Working Group included the Biobanking and Biomolecular Resources Research Infrastructure (BBMRI), the International Society for Biological and Environmental Repositories (ISBER), the European, Middle Eastern and African Society for Biopreservation and Biobanking (ESBB), the African Organisation for Research & Training in Cancer (AORTIC), the Latin American and Caribbean Biobank Network (REBLAC), the National Cancer Research Institute (NCRI), United Kingdom, the Population Project in Genomics and Society (P³G) and the Spanish National Cancer Research Centre (CNIO).
The meeting was attended by 23 participants representing 14 LMICs from all of the WHO regions (South-East Asia, Western Pacific, Africa, Europe, Middle East and Pan-America) and nine international organizations, as well as IARC staff members. During the two days, the participants discussed:
The feasibility of and need for an LMIC network, what facilities are available, and whether there are initiatives that may overlap with BCNet.
Specific aims and objectives, and short-term and long-term goals.
IARC’s role in the network and advice on future steps.
Possible sources of funding for individual and collective projects.
Steering Committee members
Dr. Maher A. Sughayer was selected and given specific terms of reference and he will submit his recommendations to IARC and NCI/CGH by May 2014.
Source: Report of the LMIC BCNet meeting
9. ESBB’S 2013 ANNUAL CONFERENCE (8-11 OCTOBER 2013). Palazzo Della Gran Guardia, Verona, Italy.
Took place in Verona, Italy from the 8th to the 11th October. ESBB collaborated with the Italian node of BBMRI which held its launch or “kick-off” meeting the day before the main conference. This was the third ESBB annual conference following on from conferences in Marseille (2011) and Granada (2012).
The conference theme was “Biobanking for the Future” and it offered a wide variety of content from across the Biobanking spectrum. Sessions included: Global Biobanking, Ancient DNA, Biobanking for Personalised Medicine, Biobanking for Conservation, Sustainability of Biobanks and the Financial Crisis, and Innovative Biobanking. Another very important new feature was the Research Biobank of the Year Competition which was held for the first time at the Verona conference.
KHCCBIO was awarded for a biobank poster.
Source: http://www.esbb.org/verona/
10. BCNET steering committee 9-12 February 2014. WHO- IARC-Lyon-France for FP7.
11. TCD and Biostór Meeting 30 April – 5 May 2014 – Ireland – Dublin
12. The 3rd Jordanian International Conference of Jordan Society for medical Laboratory sciences, Medical labs: promising horizons (March 23, 2013-March 25, 2013)
Participation of Dr. Maher Sughayer and Dr. Lina Souan at JSMLS conference presenting KHCCBIO.
Under the Patronage of Her royal highness princess Basma Bint Talal, the Jordan society for medical laboratory sciences had their 3rd Jordanian international conference of Jordan society for medical laboratory sciences “Medical labs promising horizons” In collaboration with the international federation of clinical chemistry and laboratory medicine and the arab federation of clinical biology , Landmark hotel- Amman march 23-25, 2013.
A presentation by Dr. Maher Sughayer named KHCCBIO- Supporting the Establishment of a cancer Biobank for Jordan and its Neighbouring countries through knowledge transfer & training was given, and flyers were distributed.
Source: http://www.alrai.com/article/575484.html
The 3rd Jordanian International Conference of Jordan Society for medical Laboratory sciences, Medical labs: promising horizons Scientific program and abstracts book.
13. The 8th Jordanian International Electrical and Electronics Engineering Conference, (JIEEEC 2013) 16 - 18 April 2013
JIEEEC 2013 is organized by the Jordan Engineers Association (JEA) in cooperation with the Institution of Engineering and Technology (IET) Jordan Section, the Institute of Electrical and Electronics Engineers (IEEE) Jordan section, and FP7 JEWEL.
JEWEL Workshop at Landmark hotel (April 16, 2013-April 18, 2013):
A workshop organized by the Jordan Europe-Wide Enhanced Research Links in ICT (JEWEL) project, under the FP7 INCO ERA-WIDE programme. The workshop was held in conjunction with the 8th Jordanian International Electrical and Electronics Engineering Conference (JIEEEC) 2013, under the patronage of the president of the Jordan University of Sand Technology. The presentations focused on developing links between Europe and countries in the Middle East and North Africa (MENA) and grant opportunities under the EU’s Horizon 2020 programme, starting in 2014, for collaborative projects involving Mediterranean countries. The EU project officer who follows KHCCBIO project, Tanya Dimitrova, gave a key talk describing the operation and priorities of the new Horizon 2020 programme.
KHCCBIO staff attended the workshop, distributed flyers and posted banners and presented the KHCCBIO poster. Dr. Maher A. Sughayer gave a lecture about Biobanking and the project with deliverables so far and upcoming activities and plans.
Source: JIEEEC-2013
http://oldwww.just.edu.jo/jewel/next_act.aspx
14. Arab Medical Association Against Cancer (AMAAC) Le Meridien (April 26th-27th, 2013)
In collaboration with JOS and EASO were holding The 13th Pan Arab Cancer Congress April 26th– 27th, 2013 Le Méridien Hotel Amman - Jordan Dr. Lina Souan, Dr. Maher A. Sughayer and Mohammad Jasser attended the conference, and presented the Project with the flyers and the Poster.
Source: http://amaac.org/04.htm
15. The Final International Conference Part of the Project Deliverables. Conference on Biobanking: Establishing the first Cancer Biobank in Jordan (10-11 APRIL, 2014), Le Meridian, Amman, Jordan.
King Hussein Cancer Center organized a conference titled “Conference on Cancer Biobanking: Establishing the First Cancer Biobank in Jordan,” which was sponsored by the FP7-EU program and considered as an initiative of KHCC with ESBB and WHO support. The conference was held under the patronage of HRH Princess Ghida Talal at the Le Meridian Hotel, Amman, Jordan on the 10th and 11th of April, 2014.
The conference featured plenary lectures delivered by renowned local, regional and international clinicians, researchers and biobankers. Invaluable knowledge was delivered, and new partnerships were established between biobanks all over the world. A scientific exhibition of pharmaceuticals, medical and clinical equipment/ items related to biobanking and other related products also took place to allow for discussion and exchange of information between relevant delegates and leading industrial companies.
International Speakers:
Prof. Jan-Eric Litton - Karolinska Institute, Sweden
Prof. Kurt Zatloukal - Institute of Pathology, Medical University of Graz, Graz
Prof. Pasquale De Blasio - Founding President of ESBB. Milan, Italy
Dr. Rita Lawlor - University of Verona, Verona, Italy
Dr. Marianne Henderson - National Cancer Institute, National Institutes of Health, USA
Dr. Maimuna Mendy - International Agency for Research on Cancer, Lyon, France
Dr. Manuel M. Morente - Spanish National Cancer Center, Madrid, Spain
Ms. Tanya Dimitrova - Policy Officer - EU; Brussels, Belgium
Mr. Ma’n H. Zawati - Centre of Genomics and Policy – McGill University, Canada
Regional and Local Speakers:
Prof. Mostafa Abolfotouh - King Saud Bin-Abdulaziz University for Health Sciences, Saudi Arabia
Dr. Rania M. Labib - Children's Cancer Hospital-Egypt
Dr. Sonia Abdelhak - Institute Pasteur de Tunis, Tunisia
Dr. Hadi Abderrahim - Qatar Biobank, Qatar
Dr. Ahmad Samir - Children's Cancer Hospital ,Egypt
Dr. Maher Sughayer – King Hussein Cancer Center
Dr. Lina Souan – King Hussein Cancer Center
Dr. Mamoun Ahram – Jordan University, Amman, Jordan
Topics
• Session 1: History and Current Status of Biobanking
• Session 2: Biobanking in the Middle East & Low-Income Countries
• Session 3: Role of Biobanking in Public Health & Personalized Medicine
• Session 4: Ethics in Biobanking
• Session 5: Sustainability of Biobanks
• Session 6: Networking and Globalization of Biobanks
Some of the conference’s lectures and Interviews:
http://www.youtube.com/watch?v=lpxIY-FZOSo
http://www.youtube.com/watch?v=fT08xP7qJBc
http://www.youtube.com/watch?v=7nlmsnxpD90
http://www.youtube.com/watch?v=pPkKWaVojac
http://www.youtube.com/watch?v=oa75R2RObNQ
http://www.youtube.com/watch?v=z03CGt_HyzE
http://www.youtube.com/watch?v=Zf3B4gF_cBA
http://www.youtube.com/watch?v=89nicZGOgb4
B. Summary of Radio and TV Dialogues
The following table is a summary of all Radio and TV dialogues that were conducted by Dr. Maher Sughayer and Dr. Lina Souan on behalf of KHCCBIO tissue bank.
Date Channel Interviewee
Sunday 20th, November 2011 - Press conference
- Jordan TV
- Roaya TV
- Normina TV
- Alarabeyya and MBC TV
- Al Jazeera TV
- Al Ekhbaryya TV
- Al Rai newspaper
- The Jordan Times
- Addustour
- Alarab Al yawm
- Radio Amen FM
- Petra agency
- Al ghad news Launching the Tissue Bank in Jordan/ Dr. Maher Sughayer
Sunday 20th, November 2011 - Radio Hawa Amman Interview with Dr. Maher Sughayer regarding the tissue bank
Sunday 20th, November 2011 - Radio Amen FM Interview with Dr. Lina Souan
Sunday 20th, November 2011 - Jordan TV
- Normina
- Roaya
- Jazeera Interviews with Dr. Maher Sughayer and Dr. Lina Souan
Sunday 27th, November 2011 - Al Horra TV Interview with Dr. Maher Sughayer
Wednesday 28th, April 2014 - Aljazeerah Interview with Dr. Maher Sughayer.
http://www.aljazeera.net/reportslibrary/pages/591e7d06-4b06-452e-addd-1ee4900ad0cd
April 9th, 2014 - Ro’ya TV Interview with Dr. Maher Sughayer http://youtu.be/Cn8Z98-dhn4
Potential Impact:
KHCCBIO is expected to have a major impact and contribute to medical advances by providing
high-quality human biospecimens and data to the cancer research communities world-wide.
KHCCBIO will contribute to RTD capacity building and management in Jordan and neighbouring countries, increase scientific excellence and efficacy of Jordanian research in biomedical sciences, and better integrate Jordanian science and medicine with its European neighbours resulting in enhanced participation of Jordanian organisation in future EU-Framework Programmes.
KHCCBIO will be the nucleus for the establishment of a national biorepository in the Hashemite
kingdom of Jordan which will be the first in the region. The KHCCBIO bank will increase the visibility of the King Hussein Cancer Centre within Jordan, the neighbouring countries and throughout the world, facilitating communication between centres of similar scientific interest. The KHCCBIO bank will disseminate scientific information as well as the results of research, and will result in networking opportunities for KHCC researchers with other research centres in EU Member States and Associated Countries.
The establishment of the KHCCBIO bank will encourage the next generation of researchers from
Jordan and the region to start collaborations with researchers from Europe at a much earlier stage in their career, which will enable them to place science within the context of development in the Middle East using the stored biospecimens in the KHCCBIO bank. In this respect, the KHCCBIO bank will provide better job opportunities and better access to research infrastructures for young scientists and avoid the current “brain drain” phenomena which is a central part of Jordanian career development. Furthermore, promoting the importance and benefits of such a biobank to the scientific and non-scientific community will advance research and establish personalised medicine as well as aid the development of new pharmacogenomic drugs. While the primary impact of the KHCCBIO bank is to ensure the delivery of improvements in the prevention, diagnosis and treatment of Thoracic cancer, the establishment of such a resource also represents a major investment in Jordan’s knowledge economy because it will facilitate cutting-edge academia/industry research and development. A vital effect of the biobank is to improve patient care; it is also important that patients as well as the public in general understand the purpose of the biobank and the role that patients and the public alike can play in making it a success.
KHCCBIO will collect material following the highest ethical and quality standards accompanied with extensive clinical information so that researchers global wide will be able to access this information via the online database that will be established in order to make use of these resources in their research. We further anticipate that KHCCBIO will make special tumour cell lines prepared from our ethnic background that covers the entire Middle East region and make them commercially available which will give pharmaceutical companies and researchers in Europe and the world opportunities to develop clinically sound hypotheses that will help identify new diagnostic and therapeutic targets.
KHCCBIO became partners with the Low-and Middle-Income Countries (LMIC) Biobank and Cohort Network (BCNet). BCNet provides a platform for collaboration between its partners, IARC and the international community, to support biobanking and cohort-building activities, and to develop sustainable biobanking research infrastructures to facilitate the collection of high
-quality biological samples for research, using best practice principles and guidelines.
4.1.5 The address of the project public website, if applicable as well as relevant contact details.
KHCCBIO website is running as of Sept. 2012. It displays the logo of FP7 and the common European flag along with links to the corresponding websites. It has components to learn about biobanking. It also displays the logos of all partners on the home page also with links to their corresponding websites. There is ongoing work to update the website regularly. A tool for website statistics is in place. Pages with details on the functions, dissemination and other activities are also provided. Work is on going for the content management and update so partners can upload their news directly to the website. A dynamic interactive view is done.
The website address is:
http://khccbio.khcc.jo
Contact details: Dr. Maher Sughayer, msughayer@khcc.jo
1- Home
Contains a welcome note to the website, introducing KHCCBIO objectives and role in KHCC.
Also links to Partners’ websites, EU and FP7, KHCCBIO news and activities, contact us and number of website visitors.
الصفحة الرئيسية تحتوي على معلومات عامة عن بنك الأنسجة و أخبار بنك الأنسجة و النشاطات و يوجد روابط للشركاء
في المشروع.
2- About us:
An overall overview of KHCCBIO Project, Staff and Partners.
معلومات عن بنك الأنسجة و المشروع, فريق العمل و شركاء المشروع و مهماتهم.
نبذة عنّا
انشاء اول بنك حيوي لحفظ الانسجة السرطانية في الاردن والبلدان المجاورة لها من خلال تبادل المعرفة والتدريب بدعم من الاتحاد الاوربي
ان التطور الكبير في العلوم الطبية الحيوية يزيد من اهمية تجميع ودراسة عينات الانسجة المستخرجة والفائضة عن حاجة التشخيص لمرضى السرطان , وذلك لتحديد الجينات الرئيسية والاحماض النووية والبروتينات المسببة للسرطان . ومن استخدام هذه المعلومات للكشف المبكر عن السرطان ووضع نظام علاج شخصي لعلاج السرطان .
ن مستقبل الطب المخصص يعتمد على قدرة الباحثين على المقارنة بين التركيب الجزيئي الموجود في مئات من العينات وهذا يتطلب تحديد الاختلافات التي لها قيمة تشخيصية وعلاجية فقط. الا انه وللأسف فان الغالبية العظمة من ملايين العينات الحيوية المجمعة والموجودة حاليا في جميع انحاء العالم ليست مناسبة لصنع هذا النوع من المقارنات المباشرة التي تطلبها ابحاث السرطان الحديثة .والسبب بسيط وهو عدم وجود بروتوكول موحد يحكم كيفية جمع عينات الانسجة وكيفية اعدادها وتخزينها في بنوك الانسجة . حيث ان خلل طفيف في مرحلة من تلك المراحل يمكن ان يؤدي الى نتائج غير صحيحة مما يؤدي الى استحالة التميز بين البصمات الجزيئية المرتبطة بالسرطان وغيرها . من هنا جاءت اهمية هذا المشروع .
ان مشروع بنك الانسجة هو الاول من نوعه في الاردن وسيقام بدعم جزئي من الاتحاد الاوروبي يبلغ قدره 550 الف يورو ومن المقرر ان يباشر بنك الانسجة عمله خلال العامين القادمين حيث سيتم التركيز حاليا على كتابة السياسات والاجراءات وتدريب الاطباء والتقنيين على تجميع وتخزين الانسجة حسب ارشادات نظام ارشادات الايزو.
.
3. Publications:
Contains KHCCBIO flyers and publications that can be downloaded by pressing the link, these flyers explains the project’s objectives and goals and activities of KHCCBIO so far.
تحتوي الصفحة على الكتيبات التي نشرها بنك الأنسجة و فيها شرح عن أهداف بنك الأنسجة و النشاطات التي قام بها الى الوقت الحالي.
KHCCBIO is planning to issue a newsletter on a regular basis; in order to display the project’s achievements to the targeted audience and all concerned and possible stakeholders. It will include many divisions due to the different work packages’ activities. In addition, it will highlight the occurrence of all events related to the area of biobanking and personalized medicine in and outside the project.
1. Partners:
A brief introduction of each partner; ACCEL, BiostÓr, Trinity College Dublin and KHCC.
Each thumbnail is linked to the partner’s website to read more about.
نبذة قصيرة عن شركاء المشروع أسيلوبمنت و بيوستور و كلية ترينيتي في دبلن و مركز الحسين للسرطان.
يوجد رابط عند كل شريك للموقع الالكتروني.
2. Gallery:
Photo Albums from different events; Conferences, Meetings, KHCCBIO Laboratory, Staff Training and the Project Conference Announcements.
يحتوي على صور ملتقطة من المؤتمرات و المحاضرات و مختبران بنك الأنسجة و الاجتماعات و التدريب و الاعلان عن مؤتمر افتتاح بنك الأنسجة.
3. Contact us:
You can submit any question or note from the contact us, contact information are available; location, telephone number, fax and email.
للتواصل مع بنك الأنسجة عنوان الموقع, رقم الهاتف و الفاكس و البريد الالكتروني أو من خلال الموقع الالكتروني متوفر من خلال هذه الصفحة.
List of Websites:
public website address
http://khccbio.khcc.jo
contact person
Dr. Maher Sughayer
Maher A. Sughayer MD, FCAP
Full Member and Chairman,
Pathology & Laboratory Medicine Dept.
King Hussein Cancer Center
P.O.Box 1269
Amman 11941
Jordan
Tel: +962-6-5300460 ext1551
Fax: +962-6-5300460 ext 1552
Mobile: +962-77-7491216
