Objective The main goal of this project is the establishment of a network between European, South American, North American and South African educational and research entities. This attempt will be based on an innovative scientific project aiming towards the identification of hERG (human Ether-à-go-go Related Gene) channel blockers in commonly consumed botanicals and supplements. Blocking these ion channels may result in ventricular tachyarrhythmia and an increased incidence of sudden death. Thus, the hERG channel is considered as an important antitarget. Several drugs have been removed from the market for this reason, and compounds have been blocked from proceeding further into phases of clinical development. As botanicals (comprising dietary supplements, spices, herbal medicinal products) continue to increase in popularity there is an urgent need for studies aimed to critically assess the potential cardiotoxic risks of these products.State-of-the-art methodologies and techniques will be incorporated for target-oriented identification and isolation of hERG channel blocking constituents. PK and PD studies will be performed and LC-MS based methods will be developed and applied towards the measurement of bioactive components in biofluids samples. Comparison of biofluids derived from administration of single chemical entities and corresponding botanicals will be achieved using MS- and NMR-based metabolomics. The obtained results will help to elaborate and evaluate hERG related safety aspects aiming towards the risk assessment of frequently consumed botanicals.Within this frame numerous short term and extended secondments of scientific staff will be accomplished, while the organization of several workshops will assure the proper dissemination of the produced knowledge throughout all the scientific community but also the public. Core scientific knowledge is expected to be produced and exchanged, and partnerships with future scientific potentials to be created. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugs Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-IRSES - Marie Curie Action "International Research Staff Exchange Scheme" Call for proposal FP7-PEOPLE-2011-IRSES See other projects for this call Funding Scheme MC-IRSES - International research staff exchange scheme (IRSES) Coordinator UNIVERSITAT WIEN Address Universitatsring 1 1010 Wien Austria See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Steffen Hering (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON Greece EU contribution € 86 100,00 Address 6 christou lada str 10561 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Higher or Secondary Education Establishments Administrative Contact Efi Kafentzi (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAT BASEL Switzerland EU contribution € 56 700,00 Address Petersplatz 1 4051 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Matthias Hamburger (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON Greece EU contribution € 31 500,00 Address Soranou efesiou 4 115 27 Athina See on map Region Αττική Aττική Κεντρικός Τομέας Αθηνών Activity type Research Organisations Administrative Contact Constantin Tamvakopoulos (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAET INNSBRUCK Participation ended Austria EU contribution € 44 100,00 Address Innrain 52 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Activity type Higher or Secondary Education Establishments Administrative Contact Kurt Habitzel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
