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Cognitive and Cerebrovascular Effects Induced by Low Dose Ionising Radiation

Objective

The major elements of scientific uncertainty in the context of radiation protection policy and of risk assessment for cerebrovascular diseases, set the following key topics (1) the direct assessment of health effects through epidemiological studies of groups exposed to low doses, (2) doses-response and biological effects from different types of radiation and (3) the biological processes in cells and tissues mediating the cerebrovascular effects of low-dose radiation. These 3 topics have been identified as priorities by the HLEG, the MELODI Strategic Agenda and ARCH (Agenda for Research on Chernobyl Health), and will be covered in the CEREBRAD (Cognitive and Cerebrovascular Effects Induced by Low Dose Ionising Radiation) project. CEREBRAD will address the problem of cerebrovascular effects in humans: in individuals that were exposed in utero, in cohorts of adults from the Chernobyl liquidators, and in children receiving low doses to the brain during cancer radiotherapy. We will study cognitive effects in animal models exposed to radiation at different stages of brain development, with special emphasis on early postnatal exposures, and will examine the initial and late effects induced in brain by irradiation at the cellular and molecular levels.
The main concern of CEREBRAD is to identify the potential risk of doses below 100 mGy delivered to a young child. To inform on risk estimates of the effect from internal and external exposures, as well as synergistic effect with other environmental pollutants, all these different conditions will be evaluated. The consortium is an interdisciplinary team of radiobiologists, epidemiologists, experts in neurodegenerative diseases, genomics, proteomics and bioinformatics, paediatricians and dosimetrists. Special attention will be paid to efficient project management, training, dissemination and communication with stakeholders and the general public.

Call for proposal

FP7-Fission-2011
See other projects for this call

Coordinator

STUDIECENTRUM VOOR KERNENERGIE / CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE
Address
Avenue Herrmann Debroux 40
1160 Bruxelles
Belgium
Activity type
Research Organisations
EU contribution
€ 672 567
Administrative Contact
Nathalie Impens (Dr.)

Participants (11)

ORSZAGOS FREDERIC JOLIOT-CURIE SUGARBIOLOGIAI ES SUGAREGESZSEGUGYI KUTATO INTEZET

Participation ended

Hungary
Address
Anna U 5
1221 Budapest
Activity type
Other
Administrative Contact
Geza Safrany (Dr.)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 280 500
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Riet Van Zeijl (Ms.)
AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE
Italy
EU contribution
€ 219 965
Address
Lungotevere Grande Ammiraglio Thaon Di Revel 76
00196 Roma
Activity type
Research Organisations
Administrative Contact
Simonetta Pazzaglia (Dr.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 270 000
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Jürgen Ertel (Dr.)
NEMZETI NEPEGESZSEGUGYI KOZPONT
Hungary
EU contribution
€ 270 000
Address
Albert Florian Ut 2-6
1097 Budapest
Activity type
Research Organisations
Administrative Contact
Geza Safrany (Dr.)
UNIVERSITAT ROVIRA I VIRGILI
Spain
EU contribution
€ 300 000
Address
Carrer De Escorxador
43003 Tarragona
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Victoria Linares Vidal (Dr.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 269 832
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ingvar Brandt (Prof.)
STATE INSTITUTION RESEARCH CENTER FOR RADIATION MEDICINE OF THE ACADEMY OF MEDICAL SCIENCES OF UKRAINE
Ukraine
EU contribution
€ 100 000
Address
Melnikova Street 53
04050 Kyiv
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Dimitry Bazyka (Prof.)
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
EU contribution
€ 216 852,80
Address
Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Georgia Petridou (Ms.)
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
EU contribution
€ 150 000
Address
Edgbaston
B15 2TT Birmingham
Activity type
Higher or Secondary Education Establishments
Administrative Contact
May Chung (Ms.)
INSTITUT GUSTAVE ROUSSY
France
EU contribution
€ 249 800
Address
Rue Camille Desmoulins 39
94805 Villejuif
Activity type
Research Organisations
Administrative Contact
Arnauld Forest (Mr.)