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Modular beads for regeneration of bio-cofactors in enzyme-catalysed synthesis

Objective

There is increasing interest in exploiting enzymes to carry out steps in industrial catalysis. Biocatalysts permit reactions to be carried out under mild conditions and with the exquisite chiral and regio-selectivity demanded of pharmaceutical, food and fine chemical products. A growing number of enzymes are already utilised across these industries. However, the repertoire of enzymes available for industrial redox transformations is greatly limited by the requirement of many oxidoreductase enzymes for supply of the hydride-carrying nicotinamide adenine dinucleotide (NAD) cofactors at stoichiometric levels. The high cost of these cofactors means that a regeneration system is essential. In this project, we develop towards commercial application, a convenient, cheap, modular regeneration system for the nicotinamide cofactors NAD+/NADH and NADP+/NADPH. Our innovation is likely to have broad applications in facilitating enzyme-catalysed steps in the preparation of pharmaceuticals and other fine chemicals, and to offer substantial advantages over currently available cofactor recycling systems. This project builds on ideas and early-stage results that have arisen rapidly out of an ERC Starting Grant-funded project. We now apply for funds to protect our Intellectual Property, explore the surrounding market and patent landscape, and develop our innovation into a robust demonstration.

Call for proposal

ERC-2011-PoC
See other projects for this call

Funding Scheme

CSA-SA(POC) - Supporting action (Proof of Concept)

Host institution

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Address
Wellington Square University Offices
OX1 2JD Oxford
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 73 946
Administrative Contact
Linda Pialek (Ms.)

Beneficiaries (2)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 73 946
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Linda Pialek (Ms.)
HUMBOLDT-UNIVERSITAET ZU BERLIN
Germany
EU contribution
€ 74 336
Address
Unter Den Linden 6
10117 Berlin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renate Ubachs (Ms.)