Objective "The present postdoctoral project to be carried out by Dr. Ana Jorge Finnigan at the Department of Biomedicine, University of Bergen, is integrated in the research programs carried out at Research group Biorecognition, leaded by Professor Aurora Martinez. The postdoctoral project integrates methods spanning the structural and functional characterization of complexes of tyrosine hydroxylase (TH) with proteins and membranes, and the regulation of the activity and localization of TH by small ligands, both in cells and animal models. The activities are organized in an interdisciplinary set-up of expertise and methodology managed by the applicant lab and a network of collaborators. TH catalyzes the hydroxylation of L-Tyr to DOPA, the rate-limiting step in the synthesis of catecholamine neurotransmitters and hormones in brain and neuroendocrine tissues. Due to the high relevance of well-regulated catecholamine synthesis and protein-membrane interactions in human health and neurological disease, the project is expected to contribute with novel understanding of pathogenic mechanism affecting TH stability and regulation as well as with novel therapeutic approaches aiming correction of TH misfolding and mislocalization. The therapuetical tools developed through this project may even be of application to social burden diseases such as Parkinson's disease." Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicineneurologyparkinson Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Call for proposal FP7-PEOPLE-2011-IEF See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator UNIVERSITETET I BERGEN Address Museplassen 1 5020 Bergen Norway See on map Region Norge Vestlandet Vestland Activity type Higher or Secondary Education Establishments Administrative Contact Liv-Grethe Gudmundsen (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data
