Objective
Changes in the curvature of the cell membrane play an important role in many important biological processes, including cell division, vesicle trafficking, and neurotransmission. These changes in morphology are not just a passive consequence of other events in the cell, but can also drive the action of other proteins. For example, changes in curvature are thought to affect protein binding, the gating kinetics of ion channels, and to direct the localisation of proteins in vivo.
Although current methods can measure the presence of such interactions, they cannot directly measure real-time changes in membrane curvature or correlate individual protein binding events with changes in curvature. Dr Junhong Lu has a proven track record in Biological Atomic Force Microscopy. We propose to combine his expertise with new synthetic mimics of the cell membrane recently produced in the laboratory of Dr Mark Wallace at Oxford University. This combination of methods will enable us to manipulate and characterize the curvature of the cell membrane, and study its effects on protein function using single-molecule methods.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences physical sciences optics microscopy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.