Objective
The aim of this project is to develop a new bioinformatics’ platform that will for the first time allow the identification of the key proteasic pathways involved in the development of kidney disease in an automatic and systematic way. Proteases generate peptides through cleavage of specific sites, present on given protein substrates. Interestingly, recent clinical studies have led to the identification of diagnostic and prognostic peptide biomarkers of a variety of nephropathies. The platform will thus contain a database grouping all these clinically relevant peptides and will automatically retrieve the enzymes involved in their generation by analyzing the sites that have been processed. To achieve this, the proposed work will use specific knowledge of the kidney pathophysiology in combination with state-of-the-art technologies in the bioinformatics’ field. The novelty of this project relies on: 1) automation of the process on large amount of data (gain of time); and 2) focus on enzymatic activity that will complement more classically used analyses of gene or protein expression (gain of knowledge). The disease-associated proteasic pathways identified in-silico will later be validated in a life-science lab and should lead at the long term to an improved understanding of the development of kidney diseases
Fields of science (EuroSciVoc)
- natural sciences computer and information sciences databases
- medical and health sciences basic medicine physiology pathophysiology
- social sciences sociology industrial relations automation
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
- medical and health sciences clinical medicine nephrology kidney diseases
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
M13 9PL Manchester
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.