Objective
Cycloaddition reactions are extremely potent methods to form complex heterocycles. However, [3+2]-cycloadditions across alkynes are generally ineffective for the formation of 1,3-azoles which are key constituents of natural products, pharmaceuticals and materials. This project aims to establish a convergent and readily applicable gold-catalysed formal [3+2]-cycloaddition strategy to prepare diverse highly-substituted 1,3-azoles and related heteroaromatic structures. Reaction discovery and optimization will be followed by a detailed study of the substrate scope which will include the preparation of bioactive materials to demonstrate the efficacy of the proposed methodology to the synthetic community.
The second major strand of the project will exploit the ability of this methodology to provide expedient access to functional materials, in the form of chiral aminooxazoles as the basis of organocatalyst systems. Transfer of the fellow’s prior expertise and knowledge of system design and reaction application in organocatalysis will be central to the development, study and application of this potentially privileged scaffold at the core of a range of organocatalyst families. The modular and convergent method of the oxazole synthesis will facilitate both major and fine tuning of the catalysts function in single point, dual point and triple point activation, across nucleophilic catalysis, H-bond activation, and secondary amine catalysis for iminium and enamine based processes.
As well as the research impact and added value to the project from knowledge transfer, outreach activities across several layers of the population will be performed. An accessible resource will be prepared for scientists; general public knowledge and appreciation of chemistry will be enhanced, and the enthusiasm for science in the next generation of students and potential scientists will be encouraged.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences chemical sciences catalysis
- natural sciences chemical sciences organic chemistry amines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
B15 2TT Birmingham
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.