Objective Studies conducted at the Friedrich Meischer Institute (FMI) in Basel have focused on the roles of miRNAs specific to the retina. They have recently shown that absence of functional miRNA expression has severe consequences on mature cone photoreceptors of the mouse retina; a selective and dramatic reduction of cone-specific gene expression arises with the cone-specific loss of regulation by miRNAs in adult mice. The bipolar cells act post-synaptically to the photoreceptors where they not only transmit but also process the light signal received from rods and cones. In this proposal I wish to examine whether absence of functional miRNAs have as severe implications for the bipolar cells as they do for cone photoreceptors. In addition by profiling the miRNA population of these highly specialised neurons I hope to uncover miRNA/mRNA interactions that can fine-tune synaptic transmission and thus contribute to visual processing. Fields of science medical and health sciencesclinical medicineophthalmology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-IIF - Marie Curie Action: "International Incoming Fellowships" Call for proposal FP7-PEOPLE-2011-IIF See other projects for this call Funding Scheme MC-IIF - International Incoming Fellowships (IIF) Coordinator FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION Address Maulbeerstrasse 66 4058 Basel Switzerland See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Research Organisations Administrative Contact Dorothy Searles (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all Novartis Forschungsstiftung Participation ended Switzerland EU contribution € 0,00 Address Maulbeerstrasse 66 4058 Basel See on map Activity type Research Organisations Administrative Contact Dorothy Searles (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
