Objective This project will explore the therapeutic potential of pro-resolving lipids in obesity-induced chronic kidney disease (CKD). The experienced researcher is Dr. Emma Börgeson and the mentors are Prof. Kumar Sharma (outgoing, University of California San Diego, USA) and Prof. Catherine Godson (return, University College Dublin, Ireland).‘The epidemic of obesity poses one of the most serious public health challenges in the WHO European Region’ (WHO, 2006). Obesity is associated with chronic systemic low-grade inflammation. Failure to resolve this inflammation leads to development of associated complications such as CKD. The resolution of inflammation is actively regulated by endogenous pro-resolving lipid mediators, e.g. lipoxins (LXs) and resolvins (Rvs).We hypothesise that 1) Pro-resolving lipids prevent obesity-induced adipose inflammation and thereby subvert kidney disease, 2) Humans developing obesity-related pathologies have impaired endogenous production of pro-resolving lipids. To investigate this we will assess the protective effects of pro-resolving lipids in animal models of obesity-induced kidney disease and elucidate the cellular signalling pathways involved (outgoing phase). We will correlate our findings to human obesity and investigate if development of obesity-related pathologies reflects an impairment of endogenous production of LXs and Rvs (return phase).The synergy between Prof Sharma (expertise; obesity, CKD) and Prof Godson (expertise; inflammation, CKD) will provide a unique research opportunity to combine state of the art facilities and innovative research methodology. Dr. Börgeson will acquire significant technical skills, an international network as well as management, teaching and outreach experience. The fellowship will enhance her ability to secure a future career in European biomedical research. Fields of science medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsmedical and health sciencesbasic medicinepathologymedical and health scienceshealth sciencesnutritionobesitymedical and health sciencesclinical medicinenephrologykidney diseases Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-IOF - Marie Curie Action: "International Outgoing Fellowships for Career Development" Call for proposal FP7-PEOPLE-2011-IOF See other projects for this call Funding Scheme MC-IOF - International Outgoing Fellowships (IOF) Coordinator UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Address Belfield 4 Dublin Ireland See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Administrative Contact Donal Doolan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data
