Objective
Cadherin-based cell-cell junctions regulate tissue architecture by coordinating multicellular growth and polarity. In addition to the ubiquitously expressed and widely studied E-cadherin, epithelia express other, more tissue-specific classical cadherins, often particularly during developmental epithelial rearrangements. These additional cadherins recently also have been implicated in tumor progression, but their expression and function is poorly understood.
I recently demonstrated that different classical cadherin subtypes have distinct roles in branching morphogenesis. I hypothesize that cell-cell junction control in invasive growth of developmental branching morphogenesis is recapitulated in collective cancer invasion, where tumor cells invade as strands that maintain cadherin-based cell-cell contacts. The aim is therefore to determine how stage-dependent regulation of distinct cadherins control these processes, using the following objectives:
1. To test that co-expression of E-cadherin and other cadherins control cell migration and rearrangement of the extracellular matrix and, thus, invasive physiological growth.
2. To define the role of co-expressed cadherins in collective invasive growth and resistance in cancer.
To demonstrate how cadherins accessory to E-cadherin control physiological collective invasion and growth, and how this is recapitulated in an aberrant fashion during invasive growth of epithelial cancers, I will contrast models for branching morphogenesis of kidney and mammary epithelium to neoplastic invasion of kidney and breast cancer cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
6525 XZ Nijmegen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.