Genetic Analysis of Temperature Sensation and Nociception in Caenorhabditis elegans

Informations projet

GATSNCe

N° de convention de subvention: 302077

Projet clôturé

Date de début 1 Février 2012

Date de fin 28 Février 2014

Financé au titre de

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Coût total € 52 083,33

Contribution de l’UE € 52 083,33

Coordonné par

UNIVERSITE DE FRIBOURG
Suisse

Objectif

Pain is a major medical concern and there is an undeniable need to improve the therapeutic options in pain management. In this project, a simple model organism is used to identify and characterize new potential drug targets.

Nociception is defined as the neural processes of encoding and processing noxious stimuli triggering pain. Nociception and temperature sensation are related processes. The general goal of this research project is to shed new light on their molecular and neural basis, by using the small nematode Caenorhabditis elegans. This model organism presents several advantages, including the availability of a complete nervous system wiring diagram, efficient genetic techniques, and a stereotyped avoidance behaviour in response to noxious heat, providing a simple readout of thermal nociception. Recent work by the applicant has demonstrated the suitability of this model. New assays were developed to quantify the heat avoidance behaviour and a pilot mutagenesis screen led to the identification of several genes, which mutation impairs noxious heat avoidance. The specific goals pursued in the present project are:
1) to characterize the interplay between the recently discovered “heat avoidance” genes
2) to identify more genes required for heat avoidance, by scaling up the genetic screen
3) to identify the neurons involved, by using cell-specific gene rescue in mutants and by neuronal ablation
4) to understand the logic of the neural circuit involved by expressing light-activated channels enabling an on-demand artificial neural activation

Because thermal nociception mechanisms appear to be at least partially conserved between worms and humans, characterizing the genetic and neural pathways involved will provide novel insights on potential therapeutic target for pain management.

Champ scientifique (EuroSciVoc)

CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN. Voir: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• sciences naturelles › sciences biologiques › neurobiologie
• sciences naturelles › sciences biologiques › génétique › mutation

Vous devez vous identifier ou vous inscrire pour utiliser cette fonction

Programme(s)

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thème(s)

• FP7-PEOPLE-2011-CIG - Marie-Curie Action: "Career Integration Grants"

Appel à propositions

FP7-PEOPLE-2011-CIG
Voir d’autres projets de cet appel

Régime de financement

MC-CIG -

Coordinateur

UNIVERSITE DE FRIBOURG

• Contribution de l’UE: € 52 083,33
• Adresse: AVENUE DE L EUROPE 20 ; 1700 Fribourg ; Suisse
• Région: Schweiz/Suisse/Svizzera › Espace Mittelland › Fribourg / Freiburg
• Type d’activité: Établissements d’enseignement supérieur ou secondaire
• Coût total: Aucune donnée