Objective
In plants, receptor-like kinases (RLKs) form the largest family of membrane receptors (>400) and they are involved in virtually all aspects of the plant life cycle, including development, immunity and reproduction. Although a few model RLKs, such as the steroid receptor BRI1, have been studied extensively, there are still many with unknown function. Besides, we still know very little on how those receptors are activated. Notably, the functions and mechanisms of RLK negative regulation have virtually not been addressed, while it is established that receptor inhibition play a critical role in signaling and diseases in metazoan. During my postdoctoral work, I characterized a negative regulator of BRI1 called BKI1 (for BRI1 KINASE INHIBITOR) and identified a small family of related proteins of unknown function, called MAKRs for MEMBRANE ASSOCIATED KINASE REGULATORs. Preliminary results suggest that some MAKR proteins regulate BRI1, while others control different developmental pathways, possibly regulated by unknown RLKs. Here we propose to combine biochemistry, genetic and cell biology to address the mechanisms by which BKI1/MAKRs regulate RLK activity and to identify the developmental pathways and receptors targeted by the MAKR proteins. This work should unravel the functions of RLK negative regulation as well as identify new receptor kinase involved in plant development. Altogether, our studies will provide mechanistic insight into receptor kinase signaling pathways in plant and their evolutionary relationship to well-studied mammalian systems.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.