Objective
The field of epigenetics has been developing exponentially over the last decade. However, the organization of chromatin in gametes is still poorly understood. The role of this organization in fertilization and early embryonic development is largely unknown.
For many years, I have been exploring different aspects of chromatin organization and dynamics during male gamete differentiation. The study of gametogenesis has proven to be technically challenging. My post-doctorate work, realized in the USA, demonstrated that a simple model, yeast sporulation, shares functional similarities with mammalian spermatogenesis. Taking advantage of this observation, I propose to deploy a new research program, EPIGAM2, using yeast sporulation as a powerful model for mammalian spermatogenesis.
EPIGAM2 will be hosted by the group “Exploring the Dynamics of Proteomes”, directed by Jérôme Garin (Grenoble, France). The partnership between the candidate and the host laboratory has long-term interests, reinforcing cooperation between fundamental research and the development of new methodologies in proteomics. Indeed, EPIGAM2 combines multi-dimensional approaches using genetic, biochemical, and proteomic techniques. Project management has been carefully planned, and tasks, risk analyses, and milestones are presented. Support from this Marie Curie Action is vital for the launch of this research program, allowing the complete reintegration of the candidate and adequate development of his research program.
To conclude, EPIGAM2 research program is based on a unique combination of (i) an innovative biological question, with potential implications for fertility care, cancer biology, and regenerative medicine, (ii) an original biological model, yeast spores, validated by several high profile publications, (iii) the impact of the program on the career of the candidate, the scientific community and outreach activities.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences developmental biology
- social sciences sociology demography fertility
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics epigenetics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
75015 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.