The direct and selective C-H activation of aliphatic scaffolds unlocks attractive opportunities for significantly different synthetic strategies. Although it represents an important and long-standing goal in chemistry, very few actual methods are truly practical. This project aims at achieving further mechanistic insights, focusing on steps and factors controlling the activity and selectivity of catalytic sp3 C-H bond activation processes. Asymmetric sp3 C-H bond functionalizations will be of particular interest, designing reactive chiral systems and developing novel coordinating substrates for asymmetric catalysis.
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