Objective CLINICAL NEEDEvery year in the EU ~45,300 and 330,000 women are diagnosed with ovarian and breast cancer respectively & 28,800 and 90,000 of these two groups of women will die as a consequence of these diseases. Currently there are no tools available that allow for:a) Effective screening of ovarian and/or breast cancer of sufficient sensitivity and specificity to avoid potential over-diagnosis, or;b) Stratification of patients into optimal personalised therapy regimes in ovarian/breast cancer.EpiFemCare ADVANCESProgress in personalised cancer medicine will only be possible with the development of bioassays involving the analysis of easy accessible biomaterials that contain stable target molecules reflective of disease. We will establish and clinically validate a series of blood tests based upon DNA methylation technology that will facilitate both early detection and prediction of therapeutic outcome in breast and ovarian cancer.CONSORTIUMOur pan-European academic-industrial consortium demonstrates diverse clinical, scientific & industrial expertise. We have access to the latest state of the art technologies and, integrally, the best available cohort and clinical trial sample sets required to ensure the success of the EpiFemCare program. GATC-Biotech and Genedata are Europe’s leading providers of DNA sequencing and bioinformatics for biomarker development and have developed serum DNA based prenatal tests. The clinical partners have access to unique cohort and clinical samples collected from >200,000 women well in advance of disease (UK Collaborative Trial of Ovarian Cancer Screening) or before and during treatment (SUCCESS Trial).IMPACTAs a result of refined and improved patient stratification, EpiFemCare will:- Reduce the late stage presentation of ovarian & breast cancer by 50%- Reduce the requirement for 50% of breast cancer patients to have adjuvant therapies- Reduce female cancer related fatalities as well as treatment-related morbidity by 20% Fields of science natural sciencesbiological sciencesgeneticsDNAmedical and health sciencesclinical medicineoncologybreast cancerengineering and technologyindustrial biotechnologybiomaterialsengineering and technologymedical engineeringmedical laboratory technologylaboratory samples analysisnatural sciencesbiological sciencesgeneticsepigenetics Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.1.2-1 - Development of technologies with a view to patient group stratification for personalised medicine applications Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UCL Elizabeth Garrett Anderson Institute for Women’s Health Address Gower street WC1E 6BT London United Kingdom See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Administrative Contact Greta Borg-Carbott (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all EUROFINS GENOMICS EUROPE PHARMA AND DIAGNOSTICS PRODUCTS & SERVICES SA NGER PCR GMBH Germany EU contribution € 2 136 106,00 Address Jakob stadler platz 7 78467 Konstanz See on map Region Baden-Württemberg Freiburg Konstanz Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Janet Kenklies (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data GENEDATA AG Switzerland EU contribution € 852 245,00 Address Margarethenstrasse 38 4053 Basel See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Timo Wittenberger (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data EURAM LIMITED United Kingdom EU contribution € 354 344,00 Address Lucy tower street tower house LN1 1XW Lincoln See on map Region East Midlands (England) Lincolnshire Lincolnshire Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Andrew Banasik (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany EU contribution € 249 932,00 Address Geschwister scholl platz 1 80539 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Brigitte Rack (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERZITA KARLOVA Czechia EU contribution € 230 048,00 Address Ovocny trh 560/5 116 36 Praha 1 See on map Region Česko Praha Hlavní město Praha Activity type Higher or Secondary Education Establishments Administrative Contact Kristyna Matejkova (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
