Objective
The ability of T cells to respond to a second encounter with antigen is an essential element of memory immunity and indeed a prerequisite of a successful vaccination. Many recent advances have been made in our understanding of the cellular basis of immunological memory (reviewed by Kaech) (1). However, major gaps in our knowledge on the generation and persistence of cell mediated immunological (CMI) memory still exist. In particular, factors that allow vaccines to generate long-lived memory are still not understood. It has been suggested that this may be one of the major drawbacks of non-replicating vaccines such as recombinant subunit vaccines (1).
In this regard, mice cleared of an infection with tuberculosis (TB) respond vigorously upon re-exposure to mycobacteria and are efficiently protected against re-infection, whereas the efficacy of some subunit vaccines declines over time as shown in fig. 1. The reasons for this are unknown. This data clearly demonstrates the need of more fundamental studies of immunological memory induced by vaccines.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine pneumology tuberculosis
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IIF - Marie Curie actions-Incoming International Fellowships
Coordinator
COPENHAGEN S
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.