Objective
The main objective of this research proposal is to identify and elaborate those characteristics of ENM that determine their biological hazard potential. This potential includes the ability of ENM to induce damage at the cellular, tissue, or organism levels by interacting with cellular structures leading to impairment of key cellular functions. These adverse effects may be mediated by ENM-induced alterations in gene expression and translation, but may involve also epigenetic transformation of genetic functions. We believe that it will be possible to create a set of biomarkers of ENM toxicity that are relevant in assessing and predicting the safety and toxicity of ENM across species. The ENM-organism interaction is complex and depends, not simply on the composition of ENM core, but particularly on its physico-chemical properties. In fact, important physico-chemical properties are largely governed by their surface properties. All of these factors determine the binding of different biomolecules on the surface of the ENM, the formation of a corona around the ENM core. Thus, any positive or negative biological effect of ENM in organisms may be dynamically modulated by the bio-molecule corona associated with or substituted into the ENM surface rather than the ENM on its own. The bio-molecule corona of seemingly identical ENM cores may undergo dynamic changes during their passage through different biological compartments; in other words, their biological effects are governed by this complex surface chemistry. We propose that understanding the fundamental characteristics of ENM underpinning their biological effects will provide a sound foundation with which to classify ENM according to their safety. Therefore, the overarching objective of this research is to provide a means to develop a safety classification of ENM based on an understanding of their interactions with living organisms at the molecular, cellular, and organism levels based on their material characteristics.
Fields of science
Not validated
Not validated
Programme(s)
Call for proposal
FP7-NMP-2012-LARGE-6
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Funding Scheme
CP-IP - Large-scale integrating projectCoordinator
00250 Helsinki
Finland
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Participants (38)
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33405 TALENCE
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17177 Stockholm
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4 Dublin
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2595 DA Den Haag
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33000 Bordeaux
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WC1E 6BT LONDON
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PL4 8AA Plymouth
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EH14 4AS Edinburgh
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20009 San Sebastian
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80539 MUNCHEN
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EH14 4AP Edinburgh
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20014 Turku
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Participation ended
02044 VTT ESPOO
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08225 Terrassa
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2800 Kongens Lyngby
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00185 Roma
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04109 Leipzig
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8600 Dubendorf
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69126 Heidelberg
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BS2 8JH Bristol
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12489 Berlin
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48950 Erandio
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73728 ESSLINGEN
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310027 HANGZHOU
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70919 970 Brasilia Df
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2131 Sandringham
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2531 Potchefstroom
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26505 MORGANTOWN
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21702 FREDERICK MD
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5060 SAMBREVILLE
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114 28 Stockholm
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84084 Fisciano Sa
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1120 Bruxelles / Brussel
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114 28 STOCKHOLM
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08211 CASTELLAR DEL VALLES
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M13 9PL Manchester
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20520 Turku
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00014 HELSINGIN YLIOPISTO
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